SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 8 VAL A  91
LEU A  59
PRO A  89
GLU A  85
 None
 1.21A 1jtvA-2dxaA:
undetectable		 1jtvA-2dxaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2dxa PROTEIN YBAK
(Escherichia
coli) 		5 / 10 ALA A  81
VAL A  84
ALA A 153
ILE A 155
LEU A  70
 None
 1.15A 3fl9A-2dxaA:
undetectable		 3fl9A-2dxaA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		3 / 3 ARG A  94
ILE A 103
THR A  27
 None
 0.56A 3ia4D-2dxaA:
undetectable		 3ia4D-2dxaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 7 LEU A  70
GLY A 101
ILE A 103
THR A  64
 None
 0.88A 3spkB-2dxaA:
undetectable		 3spkB-2dxaA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 6 PHE A  15
ALA A   4
THR A   2
LEU A 135
 None
 0.88A 4ejgD-2dxaA:
undetectable		 4ejgD-2dxaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 7 VAL A 128
LEU A 148
VAL A  61
THR A 114
 None
 0.97A 5e4dA-2dxaA:
undetectable
5e4dB-2dxaA:
undetectable		 5e4dA-2dxaA:
19.72
5e4dB-2dxaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 6 HIS A  18
ALA A   4
LEU A 106
TYR A  45
 None
 1.09A 5igiA-2dxaA:
undetectable		 5igiA-2dxaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		5 / 12 ILE A  17
THR A  19
LEU A 106
VAL A   5
SER A 104
 None
 1.34A 5l8oB-2dxaA:
undetectable		 5l8oB-2dxaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 5 LEU A  72
LYS A  73
ALA A  76
LEU A  79
 CL  A1201 (-3.9A)
None
None
None
 0.77A 5vkqA-2dxaA:
undetectable
5vkqD-2dxaA:
undetectable		 5vkqA-2dxaA:
7.60
5vkqD-2dxaA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 5 LEU A  72
LYS A  73
ALA A  76
LEU A  79
 CL  A1201 (-3.9A)
None
None
None
 0.77A 5vkqA-2dxaA:
undetectable
5vkqB-2dxaA:
undetectable		 5vkqA-2dxaA:
7.60
5vkqB-2dxaA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 5 LEU A  72
LYS A  73
ALA A  76
LEU A  79
 CL  A1201 (-3.9A)
None
None
None
 0.76A 5vkqB-2dxaA:
undetectable
5vkqC-2dxaA:
undetectable		 5vkqB-2dxaA:
7.60
5vkqC-2dxaA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dxa PROTEIN YBAK
(Escherichia
coli) 		4 / 5 LEU A  72
LYS A  73
ALA A  76
LEU A  79
 CL  A1201 (-3.9A)
None
None
None
 0.77A 5vkqC-2dxaA:
undetectable
5vkqD-2dxaA:
undetectable		 5vkqC-2dxaA:
7.60
5vkqD-2dxaA:
7.60