SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2dxf NUCLEOSIDE
DIPHOSPHATE KINASE
(Pyrococcus
horikoshii) 		4 / 6 MET A  79
VAL A  12
ILE A  28
ILE A 123
 None
 0.76A 3gcsA-2dxfA:
undetectable		 3gcsA-2dxfA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2dxf NUCLEOSIDE
DIPHOSPHATE KINASE
(Pyrococcus
horikoshii) 		4 / 6 MET A  79
VAL A  12
ILE A  28
ILE A 123
 None
 0.71A 3hegA-2dxfA:
undetectable		 3hegA-2dxfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2dxf NUCLEOSIDE
DIPHOSPHATE KINASE
(Pyrococcus
horikoshii) 		4 / 6 HIS A 124
GLU A 135
ASP A 127
SER A 131
 None
 1.24A 4apjA-2dxfA:
undetectable
4apjP-2dxfA:
undetectable		 4apjA-2dxfA:
14.04
4apjP-2dxfA:
5.43