SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 SER A  33
THR A  32
LEU A 128
ASP A 127
 None
 0.94A 1mxdA-2dy0A:
undetectable		 1mxdA-2dy0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 SER A  33
THR A  32
LEU A 128
ASP A 127
 None
 0.95A 1mxgA-2dy0A:
undetectable		 1mxgA-2dy0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 ASP A 127
VAL A  74
ILE A  45
LEU A  48
TYR A  41
 None
 1.13A 2dg9A-2dy0A:
undetectable		 2dg9A-2dy0A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 TYR A  41
ILE A  45
LEU A  35
VAL A  31
LEU A  34
 None
 1.12A 2w98A-2dy0A:
2.6		 2w98A-2dy0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 LEU A 129
GLU A 168
ILE A 172
 None
 0.55A 3czhA-2dy0A:
undetectable		 3czhA-2dy0A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 GLY A  67
GLY A  71
VAL A 124
ALA A  65
LEU A 109
 None
 1.10A 3dh0B-2dy0A:
2.7		 3dh0B-2dy0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 GLY A  62
GLY A  67
VAL A  85
THR A  63
VAL A 122
 None
 1.21A 4f84A-2dy0A:
3.8		 4f84A-2dy0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A  11
LYS A  39
TYR A  41
ILE A  45
LEU A  69
 None
 1.03A 4l9qB-2dy0A:
undetectable		 4l9qB-2dy0A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LYS A  39
TYR A  41
ILE A  45
LEU A  69
GLY A  71
 None
 1.08A 4l9qB-2dy0A:
undetectable		 4l9qB-2dy0A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A 123
GLU A  64
PHE A  68
GLY A  71
ALA A  75
 None
 1.07A 4retA-2dy0A:
undetectable		 4retA-2dy0A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A 123
GLU A  64
PHE A  68
GLY A  71
PHE A  82
 None
 0.80A 4retA-2dy0A:
undetectable		 4retA-2dy0A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 9 ALA A 153
GLN A   7
LEU A  48
LEU A 177
ARG A  51
 None
 1.45A 4x30A-2dy0A:
undetectable		 4x30A-2dy0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 PHE A 159
SER A 176
LEU A 129
LEU A 158
 None
 1.20A 5dzkd-2dy0A:
undetectable
5dzkr-2dy0A:
undetectable		 5dzkd-2dy0A:
24.43
5dzkr-2dy0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 PHE A 159
SER A 176
LEU A 129
LEU A 158
 None
 1.12A 5dzke-2dy0A:
undetectable
5dzks-2dy0A:
undetectable		 5dzke-2dy0A:
24.43
5dzks-2dy0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 PHE A 159
SER A 176
LEU A 129
LEU A 158
 None
 1.07A 5dzkF-2dy0A:
undetectable
5dzkT-2dy0A:
undetectable		 5dzkF-2dy0A:
24.43
5dzkT-2dy0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 ILE A  26
LEU A 158
ALA A 130
HIS A 183
 None
 1.00A 5hrqE-2dy0A:
undetectable
5hrqF-2dy0A:
undetectable
5hrqJ-2dy0A:
undetectable		 5hrqE-2dy0A:
18.03
5hrqF-2dy0A:
8.95
5hrqJ-2dy0A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 PHE A  28
ALA A  40
SER A  44
VAL A  31
ILE A  15
 None
 1.28A 5mlmA-2dy0A:
undetectable		 5mlmA-2dy0A:
18.69