SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		4 / 6 PRO A 215
MET A  30
ALA A  56
GLU A  76
 None
 1.24A 1qhyA-2dy3A:
undetectable		 1qhyA-2dy3A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 THR A 157
GLU A 169
HIS A 128
 None
 0.88A 1xwfA-2dy3A:
undetectable		 1xwfA-2dy3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 THR A 157
GLU A 169
HIS A 128
 None
 0.91A 1xwfB-2dy3A:
undetectable		 1xwfB-2dy3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 THR A 157
GLU A 169
HIS A 128
 None
 0.91A 1xwfD-2dy3A:
undetectable		 1xwfD-2dy3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		4 / 8 LEU A  29
ARG A  18
PRO A 224
GLY A 221
 None
 0.84A 2po5A-2dy3A:
undetectable		 2po5A-2dy3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		4 / 8 LEU A  29
ARG A  18
PRO A 224
GLY A 221
 None
 0.92A 2po5B-2dy3A:
2.1		 2po5B-2dy3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 PRO A 352
ASN A  39
ARG A 358
 None
 0.91A 2qeuB-2dy3A:
undetectable		 2qeuB-2dy3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 TYR A 220
ALA A  37
VAL A  45
THR A   6
PHE A 327
 None
 1.42A 2qo4A-2dy3A:
undetectable		 2qo4A-2dy3A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 LEU A 189
GLU A 151
ILE A 150
 None
 0.56A 3czhA-2dy3A:
undetectable		 3czhA-2dy3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		4 / 8 PRO A  47
ALA A  50
ALA A  54
ILE A  73
 None
 0.86A 3dtuC-2dy3A:
undetectable
3dtuD-2dy3A:
undetectable		 3dtuC-2dy3A:
20.39
3dtuD-2dy3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 PRO A 224
GLY A 216
GLY A  58
LEU A  78
HIS A 158
 None
PLP  A 401 (-3.5A)
None
None
PLP  A 401 (-4.0A)
 1.18A 3e23A-2dy3A:
undetectable		 3e23A-2dy3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A 327
VAL A 325
ASN A 330
GLY A 331
 None
 0.94A 3kmoB-2dy3A:
undetectable		 3kmoB-2dy3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 9 HIS A  15
LEU A  20
LEU A 222
LEU A 217
SER A 199
 None
None
None
PLP  A 401 (-4.2A)
PLP  A 401 (-2.7A)
 1.40A 3q1eB-2dy3A:
undetectable
3q1eD-2dy3A:
undetectable		 3q1eB-2dy3A:
15.11
3q1eD-2dy3A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 ASN A  16
ALA A  12
LYS A 233
 None
 1.03A 3runA-2dy3A:
undetectable		 3runA-2dy3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 11 GLY A  53
ALA A  54
ASP A  55
ILE A  13
ILE A  49
 None
 0.89A 3s45B-2dy3A:
undetectable		 3s45B-2dy3A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 GLU A 151
ARG A 118
HIS A 116
 None
 0.83A 4kf9A-2dy3A:
undetectable		 4kf9A-2dy3A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 SER A 310
ALA A 269
VAL A 270
 None
 0.62A 4o2bA-2dy3A:
undetectable		 4o2bA-2dy3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		4 / 8 PRO A 224
LEU A 203
VAL A 213
LEU A  20
 None
 0.99A 4pwdA-2dy3A:
undetectable		 4pwdA-2dy3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A  37
ALA A  12
ILE A  13
ASN A 345
GLY A 216
 None
None
None
None
PLP  A 401 (-3.5A)
 1.17A 4r38A-2dy3A:
undetectable		 4r38A-2dy3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A  37
ALA A  12
ILE A  13
ASN A 345
GLY A 216
 None
None
None
None
PLP  A 401 (-3.5A)
 1.19A 4r38B-2dy3A:
undetectable		 4r38B-2dy3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A  37
ALA A  12
ILE A  13
ASN A 345
GLY A 216
 None
None
None
None
PLP  A 401 (-3.5A)
 1.19A 4r38D-2dy3A:
undetectable		 4r38D-2dy3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 HIS A 149
ILE A 150
ALA A 108
ILE A  92
PHE A  88
 None
 1.12A 4rp8C-2dy3A:
undetectable		 4rp8C-2dy3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 HIS A 149
ILE A 150
ALA A 108
ILE A  92
PHE A  88
 None
 1.18A 4rp9A-2dy3A:
0.0		 4rp9A-2dy3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 LEU A   3
LEU A   4
TRP A 238
 None
 0.90A 5nwuA-2dy3A:
undetectable		 5nwuA-2dy3A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		3 / 3 GLU A 211
HIS A 195
VAL A 193
 None
 0.88A 5trqB-2dy3A:
undetectable		 5trqB-2dy3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
ALA A  54
ASP A  55
ILE A  13
ILE A  49
 None
 0.95A 6dh3A-2dy3A:
undetectable		 6dh3A-2dy3A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		5 / 12 SER A 288
ASP A 295
GLY A 293
ASP A 292
ILE A 309
 None
 1.25A 6dwnA-2dy3A:
undetectable		 6dwnA-2dy3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2dy3 ALANINE RACEMASE
(Corynebacterium
glutamicum) 		4 / 7 VAL A 140
ILE A 123
GLY A  58
ALA A  99
 None
 0.83A 6hd6B-2dy3A:
undetectable		 6hd6B-2dy3A:
12.80