SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A  94
ALA A  96
ASP A  97
GLU A  99
TRP A  60
 None
 1.12A 1errA-2dykA:
undetectable		 1errA-2dykA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 LYS A 117
LEU A  93
ARG A   9
LEU A 130
ALA A  86
 GDP  A 501 (-3.6A)
None
None
None
None
 1.32A 1hk3A-2dykA:
undetectable		 1hk3A-2dykA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 153
ALA A 155
ILE A 156
VAL A 114
ALA A  86
 None
 1.03A 1xp0A-2dykA:
undetectable		 1xp0A-2dykA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 GLY A  89
LEU A 113
LEU A 133
ASP A  97
ASP A  88
 None
 1.24A 2j2pB-2dykA:
undetectable
2j2pC-2dykA:
undetectable		 2j2pB-2dykA:
19.00
2j2pC-2dykA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 VAL A  12
GLY A   8
LEU A  84
LEU A  53
ASP A  55
 GDP  A 501 (-4.1A)
None
None
None
GDP  A 501 ( 4.9A)
 1.11A 2j2pB-2dykA:
undetectable
2j2pC-2dykA:
undetectable		 2j2pB-2dykA:
19.00
2j2pC-2dykA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 ALA A  96
ASP A  97
GLU A  99
TRP A  60
 None
 0.86A 2ouzA-2dykA:
undetectable		 2ouzA-2dykA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 ASP A 119
SER A 142
THR A 141
THR A 116
GLY A  89
 GDP  A 501 (-2.8A)
GDP  A 501 (-3.4A)
None
None
None
 1.38A 3sfuA-2dykA:
undetectable		 3sfuA-2dykA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 VAL A  87
ALA A 115
LEU A 113
GLY A 132
LEU A 127
 None
 1.05A 3zosA-2dykA:
undetectable
3zosB-2dykA:
undetectable		 3zosA-2dykA:
21.07
3zosB-2dykA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 4 ILE A 156
VAL A   5
VAL A  82
ARG A 159
 None
 1.36A 4m6tA-2dykA:
undetectable		 4m6tA-2dykA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  17
LEU A  84
VAL A  44
LYS A   3
ILE A 156
 None
 0.98A 4x1yB-2dykA:
3.7		 4x1yB-2dykA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  17
LEU A  84
VAL A  44
LYS A   3
ILE A 156
 None
 1.06A 4x1yD-2dykA:
5.1		 4x1yD-2dykA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A  17
LEU A  84
VAL A  44
LYS A   3
ILE A 156
 None
 1.02A 4x20D-2dykA:
5.0		 4x20D-2dykA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A  51
GLU A 154
LEU A  21
THR A 141
GLY A 148
 None
 1.40A 4zjlA-2dykA:
undetectable		 4zjlA-2dykA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 SER A 143
LEU A 149
ILE A 156
LEU A 153
 GDP  A 501 (-4.3A)
None
None
None
 0.89A 5te8C-2dykA:
undetectable		 5te8C-2dykA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		3 / 3 SER A  15
LYS A  14
SER A  16
 GDP  A 501 (-2.7A)
GDP  A 501 (-2.7A)
GDP  A 501 (-2.9A)
 0.84A 6az3P-2dykA:
undetectable		 6az3P-2dykA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A  88
ARG A  90
ASP A 119
GLU A 144
 None
GDP  A 501 (-3.4A)
GDP  A 501 (-2.8A)
None
 1.18A 6mn5D-2dykA:
undetectable		 6mn5D-2dykA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dyk GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 ASP A  88
ARG A  90
ASP A 119
GLU A 144
 None
GDP  A 501 (-3.4A)
GDP  A 501 (-2.8A)
None
 1.35A 6mn5E-2dykA:
undetectable		 6mn5E-2dykA:
20.50