SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		5 / 12 LEU A 331
LEU A 235
MET A 238
VAL A 404
VAL A 413
 None
 1.26A 1hrkB-2dylA:
undetectable		 1hrkB-2dylA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 4 ARG A 258
ASP A 259
LEU A 275
ARG A 384
 None
 1.28A 2ziaB-2dylA:
undetectable		 2ziaB-2dylA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		5 / 12 LEU A 331
LEU A 235
MET A 238
VAL A 404
VAL A 413
 None
 1.30A 3aqiB-2dylA:
undetectable		 3aqiB-2dylA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 6 VAL A 150
VAL A 196
ILE A 210
MET A 215
 None
 0.67A 3mssD-2dylA:
21.6		 3mssD-2dylA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		5 / 12 LEU A 331
LEU A 235
MET A 238
VAL A 404
VAL A 413
 None
 1.32A 3w1wA-2dylA:
undetectable		 3w1wA-2dylA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 7 ILE A 265
PRO A 262
GLY A 334
GLN A 227
 None
 0.86A 4g0uB-2dylA:
undetectable		 4g0uB-2dylA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 5 GLU A 220
GLU A 330
TYR A 299
PHE A 336
 None
 1.36A 4twdA-2dylA:
1.5
4twdE-2dylA:
1.6		 4twdA-2dylA:
20.54
4twdE-2dylA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 5 GLU A 220
GLU A 330
TYR A 299
PHE A 336
 None
 1.31A 4twdA-2dylA:
undetectable
4twdB-2dylA:
undetectable		 4twdA-2dylA:
20.54
4twdB-2dylA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 6 GLU A 220
GLU A 330
TYR A 299
PHE A 336
 None
 1.32A 4twdG-2dylA:
undetectable
4twdH-2dylA:
undetectable		 4twdG-2dylA:
20.54
4twdH-2dylA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 5 GLU A 220
GLU A 330
TYR A 299
PHE A 336
 None
 1.31A 4twdH-2dylA:
undetectable
4twdI-2dylA:
0.0		 4twdH-2dylA:
20.54
4twdI-2dylA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 6 ALA A 163
MET A 212
MET A 215
LEU A 266
 None
 0.82A 4wboC-2dylA:
24.2		 4wboC-2dylA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 6 ALA A 163
LEU A 214
MET A 215
LEU A 266
 None
 0.55A 4xoyA-2dylA:
10.8		 4xoyA-2dylA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 6 ALA A 163
LEU A 214
MET A 215
LEU A 266
 None
 0.66A 4xp3A-2dylA:
23.5		 4xp3A-2dylA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		5 / 12 PHE A 372
ILE A 273
PHE A 369
LEU A 328
LEU A 324
 None
 1.26A 4xumA-2dylA:
undetectable		 4xumA-2dylA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		5 / 8 VAL A 150
ALA A 163
LEU A 214
MET A 215
CYH A 218
 None
 0.70A 4zauA-2dylA:
21.9		 4zauA-2dylA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		3 / 3 VAL A 196
LEU A 136
MET A 153
 None
 0.62A 5ikrA-2dylA:
undetectable		 5ikrA-2dylA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens) 		4 / 4 TYR A 299
SER A 323
GLU A 303
ASP A 320
 None
 1.39A 5lsaA-2dylA:
undetectable		 5lsaA-2dylA:
21.78