SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2dyq AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 3
(Homo
sapiens) 		4 / 4 HIS A 395
ALA A 396
PHE A 374
GLY A 398
 None
 1.16A 1mj2B-2dyqA:
undetectable		 1mj2B-2dyqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2dyq AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 3
(Homo
sapiens) 		4 / 4 HIS A 395
ALA A 396
PHE A 374
GLY A 398
 None
 1.20A 1mj2D-2dyqA:
undetectable		 1mj2D-2dyqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2dyq AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 3
(Homo
sapiens) 		4 / 4 HIS A 395
ALA A 396
PHE A 374
GLY A 398
 None
 1.17A 1mjoB-2dyqA:
undetectable		 1mjoB-2dyqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2dyq AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 3
(Homo
sapiens) 		4 / 4 HIS A 395
ALA A 396
PHE A 374
GLY A 398
 None
 1.17A 1mjoA-2dyqA:
undetectable		 1mjoA-2dyqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2dyq AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 3
(Homo
sapiens) 		4 / 4 HIS A 395
ALA A 396
PHE A 374
GLY A 398
 None
 1.18A 1mjoD-2dyqA:
undetectable		 1mjoD-2dyqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2dyq AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 3
(Homo
sapiens) 		4 / 8 ALA A 402
GLN A 289
LEU A 399
TYR A 291
 None
 1.03A 3qj7A-2dyqA:
undetectable
3qj7D-2dyqA:
undetectable		 3qj7A-2dyqA:
21.37
3qj7D-2dyqA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 2dyq AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 3
(Homo
sapiens) 		4 / 5 VAL A 362
LEU A 376
ILE A 365
VAL A 333
 None
 0.94A 4a9kB-2dyqA:
undetectable		 4a9kB-2dyqA:
21.09