SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 7 LEU A 134
ILE A 103
THR A 117
GLN A  64
 None
 1.22A 1kglA-2dyuA:
1.3		 1kglA-2dyuA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		5 / 12 ASP A  79
GLU A 105
ARG A 132
ILE A 119
ILE A 127
 None
 1.18A 1kijA-2dyuA:
undetectable		 1kijA-2dyuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 8 PHE A 135
TYR A 131
MET A 150
TYR A 186
 None
 1.24A 1xqlA-2dyuA:
2.3
1xqlB-2dyuA:
2.4		 1xqlA-2dyuA:
20.43
1xqlB-2dyuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 8 TYR A 186
PHE A 135
TYR A 131
MET A 150
 None
 1.22A 1xqlA-2dyuA:
2.3
1xqlB-2dyuA:
2.4		 1xqlA-2dyuA:
20.43
1xqlB-2dyuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 5 LEU A  78
GLY A  82
ILE A 119
ILE A 103
 None
 0.77A 2q9rA-2dyuA:
undetectable		 2q9rA-2dyuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 7 VAL A 100
TYR A  88
CYH A  92
ILE A  56
 None
 1.35A 2xz5B-2dyuA:
undetectable
2xz5E-2dyuA:
undetectable		 2xz5B-2dyuA:
19.29
2xz5E-2dyuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 7 ILE A  56
VAL A 100
TYR A  88
CYH A  92
 None
 1.33A 2xz5D-2dyuA:
undetectable
2xz5E-2dyuA:
undetectable		 2xz5D-2dyuA:
19.29
2xz5E-2dyuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		5 / 9 ALA A 118
ILE A  57
GLY A  99
ILE A 121
THR A  63
 None
 1.04A 3el4B-2dyuA:
undetectable		 3el4B-2dyuA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		5 / 11 ALA A 118
ILE A  57
GLY A  99
ILE A 121
THR A  63
 None
 1.12A 3spkA-2dyuA:
undetectable		 3spkA-2dyuA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		5 / 12 ILE A 189
ILE A 165
ALA A 118
ALA A 162
LEU A 174
 None
 0.95A 3uvvA-2dyuA:
undetectable		 3uvvA-2dyuA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 8 ILE A  19
ILE A 253
VAL A  53
GLY A  49
 None
 0.75A 4ac9C-2dyuA:
undetectable		 4ac9C-2dyuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 8 VAL A 100
TYR A  88
CYH A  92
ILE A  56
 None
 1.12A 4bqtC-2dyuA:
undetectable
4bqtD-2dyuA:
undetectable		 4bqtC-2dyuA:
18.99
4bqtD-2dyuA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2dyu FORMAMIDASE
(Helicobacter
pylori) 		4 / 8 ARG A 188
LEU A 174
ILE A 165
MET A 150
 None
 0.97A 4xtaB-2dyuA:
undetectable		 4xtaB-2dyuA:
20.46