SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 7 PHE A 358
PHE A 459
PHE A 461
VAL A 243
 None
 0.95A 1lh6A-2dzdA:
undetectable		 1lh6A-2dzdA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 7 GLU A 245
PHE A 421
MET A 414
ALA A 410
 None
 1.33A 1linA-2dzdA:
undetectable		 1linA-2dzdA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 7 ALA A 153
ILE A 160
ILE A 162
PHE A 186
 None
 0.81A 1upfB-2dzdA:
undetectable		 1upfB-2dzdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		5 / 12 ALA A  82
ASP A  81
ILE A 317
ILE A  30
ILE A 108
 None
 0.85A 2b60A-2dzdA:
undetectable		 2b60A-2dzdA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		5 / 10 TYR A 289
ILE A 291
ILE A 260
GLU A 280
ILE A 214
 None
 1.38A 2dm6A-2dzdA:
4.9
2dm6B-2dzdA:
5.1		 2dm6A-2dzdA:
22.65
2dm6B-2dzdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		5 / 12 ALA A  82
ASP A  81
ILE A 317
ILE A  30
ILE A 108
 None
 0.68A 2hs1A-2dzdA:
undetectable		 2hs1A-2dzdA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 8 LYS A 242
ASN A 294
ARG A 296
GLU A 300
 None
 0.88A 2ys6A-2dzdA:
27.3		 2ys6A-2dzdA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		5 / 10 ARG A  20
ILE A 297
GLY A  86
LEU A 115
ILE A 108
 None
 1.34A 3adsA-2dzdA:
undetectable		 3adsA-2dzdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 ASN A 382
ASP A  40
ARG A 296
 None
 0.92A 3k13C-2dzdA:
undetectable		 3k13C-2dzdA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 GLU A  63
LEU A  66
ASP A  67
 None
 0.48A 3ko0A-2dzdA:
undetectable		 3ko0A-2dzdA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 GLU A 112
LEU A 115
ASP A 116
 None
 0.39A 3ko0A-2dzdA:
undetectable		 3ko0A-2dzdA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 GLU A 112
LEU A 115
ASP A 116
 None
 0.41A 3ko0T-2dzdA:
undetectable		 3ko0T-2dzdA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 7 PHE A 358
ILE A 345
LEU A 418
ARG A 238
 None
 0.96A 3nxuA-2dzdA:
undetectable		 3nxuA-2dzdA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 4 GLY A 373
GLY A 375
THR A 402
LEU A 400
 None
 0.95A 3si7C-2dzdA:
undetectable
3si7D-2dzdA:
undetectable		 3si7C-2dzdA:
21.03
3si7D-2dzdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 5 HIS A  45
GLY A  15
TYR A  47
TYR A  44
 None
 1.34A 4ae1B-2dzdA:
undetectable		 4ae1B-2dzdA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 8 ARG A  20
GLN A 217
GLY A 277
THR A 278
 None
 0.93A 4k87A-2dzdA:
3.2		 4k87A-2dzdA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		6 / 7 LYS A 242
ASN A 294
ARG A 296
GLN A 298
VAL A 299
GLU A 300
 None
 0.76A 4mv7A-2dzdA:
54.0		 4mv7A-2dzdA:
45.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		5 / 11 LEU A 433
GLU A 434
PHE A 442
LEU A 443
ALA A 411
 None
 0.93A 4wnuA-2dzdA:
undetectable		 4wnuA-2dzdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 5 LEU A 146
ALA A 151
VAL A 176
ILE A 160
 None
 0.96A 4xe3B-2dzdA:
undetectable		 4xe3B-2dzdA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		5 / 10 SER A 327
GLN A 217
LEU A 229
SER A 324
LEU A 325
 None
 1.22A 4yiaA-2dzdA:
undetectable		 4yiaA-2dzdA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A 297
THR A 308
ILE A 307
ALA A 247
GLU A 245
 None
 0.91A 5vceA-2dzdA:
undetectable		 5vceA-2dzdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2dzd PYRUVATE CARBOXYLASE
(Geobacillus
thermodenitrific
ans) 		4 / 4 GLY A 381
ARG A  14
ASN A 382
LEU A 396
 None
 0.97A 6b58A-2dzdA:
3.4		 6b58A-2dzdA:
22.84