SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 2dzn PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 107
HIS A  77
CYH A 110
TRP A  73
 None
 1.22A 3ai8B-2dznA:
undetectable		 3ai8B-2dznA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2dzn PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  64
ILE A  78
ALA A  79
THR A  52
 None
 0.76A 3mdrA-2dznA:
undetectable		 3mdrA-2dznA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2dzn 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 362
GLY A 116
LEU A 113
VAL A 108
THR A 104
 None
 1.19A 4wnwA-2dznB:
undetectable		 4wnwA-2dznB:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2dzn 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 371
THR A 104
ASN A 105
 None
 0.65A 6baaE-2dznB:
undetectable		 6baaE-2dznB:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2dzn 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 371
THR A 104
ASN A 105
 None
 0.65A 6baaF-2dznB:
undetectable		 6baaF-2dznB:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2dzn 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 371
THR A 104
ASN A 105
 None
 0.66A 6baaG-2dznB:
undetectable		 6baaG-2dznB:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2dzn 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 371
THR A 104
ASN A 105
 None
 0.66A 6baaH-2dznB:
undetectable		 6baaH-2dznB:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2dzn PROBABLE 26S
PROTEASOME
REGULATORY SUBUNIT
P28
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 211
VAL A 194
ALA A 190
VAL A 228
GLY A 187
 None
 1.13A 6bklA-2dznA:
undetectable
6bklB-2dznA:
undetectable
6bklC-2dznA:
undetectable
6bklD-2dznA:
undetectable		 6bklA-2dznA:
7.34
6bklB-2dznA:
7.34
6bklC-2dznA:
7.34
6bklD-2dznA:
7.34