SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		3 / 3 GLN A 371
HIS A 397
PRO A 376
 None
 0.71A 1d8cA-2e0iA:
undetectable		 1d8cA-2e0iA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.27A 1jhoA-2e0iA:
undetectable		 1jhoA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 8 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.27A 1jhqA-2e0iA:
undetectable		 1jhqA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.26A 1jhrA-2e0iA:
undetectable		 1jhrA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 8 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.26A 1jhvA-2e0iA:
undetectable		 1jhvA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.25A 1jhyA-2e0iA:
undetectable		 1jhyA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.26A 1l4nA-2e0iA:
undetectable		 1l4nA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.25A 1l5kA-2e0iA:
undetectable		 1l5kA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.27A 1l5lA-2e0iA:
undetectable		 1l5lA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 223
GLY A 187
PHE A 222
SER A  57
GLY A 192
 None
 1.28A 1l5mA-2e0iA:
undetectable		 1l5mA-2e0iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		4 / 6 PRO A 376
LYS A 379
ALA A 209
GLU A 210
 None
 1.32A 1qhyA-2e0iA:
undetectable		 1qhyA-2e0iA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		3 / 3 ASP A  36
PHE A 102
ARG A  38
 None
FAD  A1200 ( 3.9A)
None
 0.84A 2a3aA-2e0iA:
undetectable		 2a3aA-2e0iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		4 / 8 PHE A 162
LEU A  19
LEU A  61
LEU A  72
 None
 0.97A 2bfpC-2e0iA:
2.3		 2bfpC-2e0iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		3 / 3 ASN A  20
ASP A 126
ARG A 190
 None
 0.90A 3k13C-2e0iA:
undetectable		 3k13C-2e0iA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 175
ILE A  55
PHE A   7
LEU A  59
SER A 168
 None
 1.18A 3ko0A-2e0iA:
undetectable
3ko0B-2e0iA:
0.0
3ko0C-2e0iA:
undetectable
3ko0D-2e0iA:
undetectable		 3ko0A-2e0iA:
12.59
3ko0B-2e0iA:
12.59
3ko0C-2e0iA:
12.59
3ko0D-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 12 SER A 168
LEU A 175
ILE A  55
PHE A   7
LEU A  59
 None
 1.08A 3ko0G-2e0iA:
0.0
3ko0H-2e0iA:
undetectable
3ko0I-2e0iA:
0.0
3ko0J-2e0iA:
0.0		 3ko0G-2e0iA:
12.59
3ko0H-2e0iA:
12.59
3ko0I-2e0iA:
12.59
3ko0J-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 11 SER A 168
LEU A  59
LEU A 175
ILE A  55
PHE A   7
 None
 1.16A 3ko0A-2e0iA:
undetectable
3ko0B-2e0iA:
0.0
3ko0I-2e0iA:
0.0
3ko0J-2e0iA:
0.0		 3ko0A-2e0iA:
12.59
3ko0B-2e0iA:
12.59
3ko0I-2e0iA:
12.59
3ko0J-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  59
LEU A 175
ILE A  55
PHE A   7
SER A 168
 None
 1.10A 3ko0K-2e0iA:
undetectable
3ko0L-2e0iA:
undetectable
3ko0M-2e0iA:
undetectable
3ko0N-2e0iA:
undetectable		 3ko0K-2e0iA:
12.59
3ko0L-2e0iA:
12.59
3ko0M-2e0iA:
12.59
3ko0N-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 175
ILE A  55
PHE A   7
LEU A  59
SER A 168
 None
 1.14A 3ko0M-2e0iA:
0.0
3ko0N-2e0iA:
undetectable
3ko0O-2e0iA:
undetectable
3ko0P-2e0iA:
undetectable		 3ko0M-2e0iA:
12.59
3ko0N-2e0iA:
12.59
3ko0O-2e0iA:
12.59
3ko0P-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 12 SER A 168
LEU A  59
LEU A 175
ILE A  55
PHE A   7
 None
 1.14A 3ko0M-2e0iA:
0.0
3ko0N-2e0iA:
undetectable
3ko0O-2e0iA:
undetectable
3ko0P-2e0iA:
undetectable		 3ko0M-2e0iA:
12.59
3ko0N-2e0iA:
12.59
3ko0O-2e0iA:
12.59
3ko0P-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A 249
HIS A 259
LEU A 128
PHE A 135
TYR A 265
 None
 1.35A 3vn2A-2e0iA:
undetectable		 3vn2A-2e0iA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 145
SER A 133
LEU A 134
THR A 141
 None
 1.32A 4an2A-2e0iA:
undetectable		 4an2A-2e0iA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		4 / 6 ILE A 381
ASP A 375
GLY A 297
VAL A 315
 None
 1.08A 4oltA-2e0iA:
undetectable		 4oltA-2e0iA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		3 / 3 ASP A  98
ARG A 228
ARG A  12
 FAD  A1200 (-3.8A)
None
None
 0.93A 4x5iA-2e0iA:
undetectable		 4x5iA-2e0iA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE
(Sulfurisphaera
tokodaii) 		4 / 6 LEU A 319
THR A 289
TRP A 368
GLN A 371
 None
 1.24A 5h8tA-2e0iA:
undetectable		 5h8tA-2e0iA:
16.44