SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E
(Chlorobaculum
tepidum) 		5 / 11 ALA A  50
LEU A  12
LEU A  54
LEU A  59
ALA A 100
 None
 1.09A 1h9zA-2e0nA:
undetectable		 1h9zA-2e0nA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E
(Chlorobaculum
tepidum) 		4 / 8 GLY A  15
GLY A  13
GLY A 105
LEU A  12
 SAH  A 300 ( 4.8A)
None
SAH  A 300 (-3.5A)
None
 0.63A 1qzzA-2e0nA:
2.3		 1qzzA-2e0nA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E
(Chlorobaculum
tepidum) 		5 / 12 LEU A 230
ALA A 139
MET A 145
SER A 239
LEU A 241
 None
 1.45A 1ya3B-2e0nA:
undetectable		 1ya3B-2e0nA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E
(Chlorobaculum
tepidum) 		5 / 10 PRO A  37
SER A 111
LEU A  54
SER A   9
SER A  11
 None
 1.41A 3ijxB-2e0nA:
undetectable
3ijxD-2e0nA:
undetectable		 3ijxB-2e0nA:
21.99
3ijxD-2e0nA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E
(Chlorobaculum
tepidum) 		4 / 4 SER A   9
SER A 111
THR A 112
SER A 114
 None
 1.46A 3loqA-2e0nA:
0.0		 3loqA-2e0nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E
(Chlorobaculum
tepidum) 		5 / 8 LEU A  12
GLY A 105
VAL A 104
ALA A  50
LEU A  54
 None
SAH  A 300 (-3.5A)
None
None
None
 1.25A 4zauA-2e0nA:
undetectable		 4zauA-2e0nA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E
(Chlorobaculum
tepidum) 		4 / 6 LEU A 155
CYH A 232
HIS A 173
LEU A 170
 None
 1.40A 5hrqD-2e0nA:
undetectable
5hrqG-2e0nA:
undetectable
5hrqH-2e0nA:
undetectable		 5hrqD-2e0nA:
10.93
5hrqG-2e0nA:
6.63
5hrqH-2e0nA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E
(Chlorobaculum
tepidum) 		5 / 8 ILE A 137
ALA A 138
VAL A 231
HIS A 235
VAL A 177
 None
 1.14A 5l94A-2e0nA:
undetectable		 5l94A-2e0nA:
22.41