SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 7 ALA A  46
GLU A 563
LEU A 564
VAL A 397
MET A  50
 None
 1.47A 1hk2A-2e0wA:
undetectable		 1hk2A-2e0wA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 THR A 490
GLY A 483
GLU A 548
GLU A 526
SER A 481
 None
 1.17A 1odiA-2e0wA:
undetectable		 1odiA-2e0wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 THR A 490
GLY A 483
GLU A 548
GLU A 526
SER A 481
 None
 1.18A 1odiB-2e0wA:
undetectable		 1odiB-2e0wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 THR A 490
GLY A 483
GLU A 548
GLU A 526
SER A 481
 None
 1.17A 1odiC-2e0wA:
undetectable		 1odiC-2e0wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 THR A 490
GLY A 483
GLU A 548
GLU A 526
SER A 481
 None
 1.19A 1odiD-2e0wA:
undetectable		 1odiD-2e0wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 THR A 490
GLY A 483
GLU A 548
GLU A 526
SER A 481
 None
 1.27A 1odiE-2e0wA:
undetectable		 1odiE-2e0wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 THR A 490
GLY A 483
GLU A 548
GLU A 526
SER A 481
 None
 1.23A 1odiF-2e0wA:
undetectable		 1odiF-2e0wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 8 LEU A 231
TYR A  81
ILE A 425
ILE A 234
ILE A 247
 None
 1.26A 2bu8A-2e0wA:
undetectable		 2bu8A-2e0wA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 177
VAL A 170
GLY A 424
ILE A 425
VAL A 151
 None
 1.00A 2uxpB-2e0wA:
0.0		 2uxpB-2e0wA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 SER A 485
THR A 479
ILE A 300
SER A 289
HIS A 393
 None
 1.25A 2vdyB-2e0wA:
undetectable		 2vdyB-2e0wA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		3 / 3 ARG A 114
ARG A 459
PRO A 460
 None
 1.01A 2wljA-2e0wA:
undetectable		 2wljA-2e0wA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP A 398
 None
 1.08A 2yvlB-2e0wA:
undetectable		 2yvlB-2e0wA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP A 398
 None
 1.10A 2yvlC-2e0wA:
undetectable		 2yvlC-2e0wA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP A 398
 None
 1.10A 2yvlD-2e0wA:
undetectable		 2yvlD-2e0wA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 THR A 475
ALA A  52
THR A  59
VAL A  63
LEU A  66
 None
 1.17A 3a51E-2e0wA:
undetectable		 3a51E-2e0wA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 6 TYR A 501
PHE A 317
PHE A 529
PHE A 514
 None
 1.46A 3af3A-2e0wA:
undetectable		 3af3A-2e0wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 8 PRO A 200
ASN A 201
HIS A 202
GLY A 415
 None
 0.60A 3em0B-2e0wA:
0.3		 3em0B-2e0wA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 8 GLY A  62
ALA A  75
ASP A  74
GLY A  80
LEU A  83
 None
 1.38A 3em6A-2e0wA:
undetectable		 3em6A-2e0wA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 7 MET A 255
LEU A 143
SER A 423
GLY A  95
 None
 1.12A 3hcnA-2e0wA:
undetectable		 3hcnA-2e0wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 LEU A 492
ILE A 300
SER A 295
SER A 485
GLY A 296
 None
 1.27A 3ijxB-2e0wA:
undetectable
3ijxD-2e0wA:
undetectable		 3ijxB-2e0wA:
19.38
3ijxD-2e0wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 LEU A 492
ILE A 300
SER A 295
SER A 485
GLY A 296
 None
 1.30A 3ik6B-2e0wA:
undetectable
3ik6E-2e0wA:
undetectable		 3ik6B-2e0wA:
19.38
3ik6E-2e0wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 LEU A 492
ILE A 300
SER A 295
SER A 485
GLY A 296
 None
 1.28A 3iluB-2e0wA:
undetectable
3iluE-2e0wA:
undetectable		 3iluB-2e0wA:
19.38
3iluE-2e0wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ILE A 300
SER A 295
SER A 485
GLY A 296
LEU A 492
 None
 1.27A 3iluB-2e0wA:
undetectable
3iluE-2e0wA:
undetectable		 3iluB-2e0wA:
19.38
3iluE-2e0wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 8 GLU A 330
HIS A 516
ILE A 325
LYS A 373
 None
 1.20A 3kp6A-2e0wA:
undetectable
3kp6B-2e0wA:
undetectable		 3kp6A-2e0wA:
15.43
3kp6B-2e0wA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 7 LEU A 307
LEU A 492
SER A 498
THR A 479
 None
 1.05A 3lm8B-2e0wA:
undetectable
3lm8D-2e0wA:
undetectable		 3lm8B-2e0wA:
17.89
3lm8D-2e0wA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 THR A 489
GLY A 297
GLY A 296
ASN A 305
VAL A 301
 None
 0.87A 3nk7A-2e0wA:
undetectable		 3nk7A-2e0wA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 6 ALA A 329
ILE A 325
LEU A 307
ALA A 360
 None
 0.83A 3r9sA-2e0wA:
undetectable		 3r9sA-2e0wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 6 ALA A 329
ILE A 325
LEU A 307
ALA A 360
 None
 0.82A 3r9sC-2e0wA:
undetectable		 3r9sC-2e0wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 9 ALA A 333
ASP A 336
ILE A 363
ILE A 325
LEU A 304
 None
 1.25A 3u7sB-2e0wA:
undetectable		 3u7sB-2e0wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		6 / 12 LEU A 227
ILE A 425
GLY A 421
ASN A 204
ILE A 251
ALA A 252
 None
 1.40A 3uwlB-2e0wA:
undetectable		 3uwlB-2e0wA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 TYR A  81
TYR A 408
GLY A 149
GLY A  96
PHE A 154
 None
 1.10A 3vywA-2e0wA:
undetectable		 3vywA-2e0wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 TYR A  81
TYR A 408
GLY A 149
GLY A  96
PHE A 154
 None
 1.11A 3vywD-2e0wA:
undetectable		 3vywD-2e0wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 8 SER A 388
ASN A 389
THR A 409
GLY A 415
 None
 1.00A 4fo4A-2e0wA:
undetectable		 4fo4A-2e0wA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.07A 4fp9A-2e0wA:
undetectable		 4fp9A-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.06A 4fp9C-2e0wA:
undetectable		 4fp9C-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.06A 4fp9D-2e0wA:
undetectable		 4fp9D-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.06A 4fp9F-2e0wA:
undetectable		 4fp9F-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.00A 4fzvA-2e0wA:
undetectable		 4fzvA-2e0wA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 LEU A 231
LEU A  83
PRO A  88
GLN A 224
ALA A 177
 None
 1.07A 4hwkB-2e0wA:
undetectable		 4hwkB-2e0wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 LEU A 231
LEU A  83
PRO A  88
GLN A 224
ALA A 177
 None
 1.09A 4hwkC-2e0wA:
undetectable		 4hwkC-2e0wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 LEU A 231
LEU A  83
PRO A  88
GLN A 224
ALA A 177
 None
 1.09A 4hwkD-2e0wA:
undetectable		 4hwkD-2e0wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		3 / 3 ARG A 102
ASP A 398
ASP A  74
 None
 0.88A 4kicB-2e0wA:
undetectable		 4kicB-2e0wA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ASP A 398
GLY A 401
VAL A  73
ILE A 101
THR A 163
 None
 0.97A 4njvC-2e0wA:
undetectable		 4njvC-2e0wA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 ASP A 398
GLY A 401
VAL A  73
ILE A 101
THR A 163
 None
 0.91A 4njvD-2e0wA:
undetectable		 4njvD-2e0wA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  95
GLY A  96
SER A 462
 None
 1.01A 4qvlK-2e0wA:
undetectable
4qvlL-2e0wA:
2.8		 4qvlK-2e0wA:
17.06
4qvlL-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  96
GLY A  97
SER A 462
 None
 1.01A 4qvlK-2e0wA:
undetectable
4qvlL-2e0wA:
2.8		 4qvlK-2e0wA:
17.06
4qvlL-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  95
GLY A  96
SER A 462
 None
 1.01A 4qvlY-2e0wA:
undetectable
4qvlZ-2e0wA:
undetectable		 4qvlY-2e0wA:
17.06
4qvlZ-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  96
GLY A  97
SER A 462
 None
 1.00A 4qvlY-2e0wA:
undetectable
4qvlZ-2e0wA:
undetectable		 4qvlY-2e0wA:
17.06
4qvlZ-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 ALA A 391
THR A 392
GLY A  95
GLY A  96
SER A 462
 None
 1.00A 4qvmY-2e0wA:
2.4
4qvmZ-2e0wA:
undetectable		 4qvmY-2e0wA:
17.06
4qvmZ-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 ALA A 391
THR A 392
GLY A  96
GLY A  97
SER A 462
 None
 0.99A 4qvmY-2e0wA:
2.4
4qvmZ-2e0wA:
undetectable		 4qvmY-2e0wA:
17.06
4qvmZ-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  95
GLY A  96
SER A 462
 None
 1.02A 4qvwK-2e0wA:
undetectable
4qvwL-2e0wA:
2.8		 4qvwK-2e0wA:
17.30
4qvwL-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  96
GLY A  97
SER A 462
 None
 0.99A 4qvwK-2e0wA:
undetectable
4qvwL-2e0wA:
2.8		 4qvwK-2e0wA:
17.30
4qvwL-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  95
GLY A  96
SER A 462
 None
 1.02A 4qvwY-2e0wA:
undetectable
4qvwZ-2e0wA:
undetectable		 4qvwY-2e0wA:
17.30
4qvwZ-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  96
GLY A  97
SER A 462
 None
 0.99A 4qvwY-2e0wA:
undetectable
4qvwZ-2e0wA:
undetectable		 4qvwY-2e0wA:
17.30
4qvwZ-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  95
GLY A  96
SER A 462
 None
 0.98A 4qw1K-2e0wA:
undetectable
4qw1L-2e0wA:
2.8		 4qw1K-2e0wA:
17.06
4qw1L-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  96
GLY A  97
SER A 462
 None
 1.02A 4qw1K-2e0wA:
undetectable
4qw1L-2e0wA:
2.8		 4qw1K-2e0wA:
17.06
4qw1L-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		3 / 3 SER A 145
ASP A 240
ASP A 266
 None
 0.74A 4uckA-2e0wA:
undetectable		 4uckA-2e0wA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 8 ALA A 235
ILE A 234
ALA A  82
TYR A  81
LEU A  93
 None
 1.05A 4v1fA-2e0wA:
undetectable
4v1fB-2e0wA:
undetectable		 4v1fA-2e0wA:
12.15
4v1fB-2e0wA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ASP A  74
ASN A  71
VAL A  73
VAL A 404
THR A 109
 None
 1.43A 4yhaC-2e0wA:
undetectable		 4yhaC-2e0wA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  95
GLY A  96
SER A 462
 None
 1.01A 5bxnK-2e0wA:
undetectable
5bxnL-2e0wA:
2.7		 5bxnK-2e0wA:
17.06
5bxnL-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  96
GLY A  97
SER A 462
 None
 1.01A 5bxnK-2e0wA:
undetectable
5bxnL-2e0wA:
2.7		 5bxnK-2e0wA:
17.06
5bxnL-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  95
GLY A  96
SER A 462
 None
 1.01A 5bxnY-2e0wA:
undetectable
5bxnZ-2e0wA:
2.7		 5bxnY-2e0wA:
17.06
5bxnZ-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 391
THR A 392
GLY A  96
GLY A  97
SER A 462
 None
 1.02A 5bxnY-2e0wA:
undetectable
5bxnZ-2e0wA:
2.7		 5bxnY-2e0wA:
17.06
5bxnZ-2e0wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		3 / 3 MET A 550
HIS A 515
GLY A 484
 None
 0.79A 5gwzB-2e0wA:
undetectable		 5gwzB-2e0wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 5 ARG A 337
SER A 295
SER A 294
SER A 463
 None
 1.29A 5hswA-2e0wA:
undetectable		 5hswA-2e0wA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 TYR A 243
LEU A 267
GLY A  94
ILE A 425
TYR A 408
 None
 1.00A 5ifuA-2e0wA:
undetectable		 5ifuA-2e0wA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		3 / 3 LYS A  29
PRO A  31
LYS A 313
 None
 1.11A 5y9yA-2e0wA:
undetectable		 5y9yA-2e0wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 5 GLN A 324
THR A 489
HIS A 515
LEU A 523
 None
 1.11A 6gbnB-2e0wA:
undetectable		 6gbnB-2e0wA:
23.02