SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 GLY A 280
VAL A 287
THR A 355
ASN A 305
HIS A 299
 None
 1.29A 1v3qE-2e0xA:
undetectable		 1v3qE-2e0xA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 LEU B 503
ALA B 508
MET A 326
LEU B 492
THR B 467
 None
 1.45A 2aa6B-2e0xB:
undetectable		 2aa6B-2e0xB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 11 GLU A 249
ALA A 252
ILE A 262
ALA B 420
ASP A 266
 None
 1.32A 2admA-2e0xA:
undetectable		 2admA-2e0xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 11 GLU A 249
ALA A 252
ILE A 262
ALA B 420
ASP A 266
 None
 1.32A 2admB-2e0xA:
undetectable		 2admB-2e0xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 9 ILE B 425
ILE B 418
GLY B 421
ALA B 420
THR B 416
 None
 1.32A 2dtjA-2e0xB:
undetectable
2dtjB-2e0xB:
undetectable		 2dtjA-2e0xB:
21.40
2dtjB-2e0xB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 THR B 407
TYR B 408
LEU A 158
GLY A 162
ALA A  76
 None
 1.00A 2fk8A-2e0xB:
undetectable		 2fk8A-2e0xB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 9 VAL A 287
VAL B 496
ASP B 500
ILE B 499
VAL B 495
 None
 1.32A 2l8mA-2e0xA:
undetectable		 2l8mA-2e0xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 LEU A 383
ARG A 379
ILE A 378
THR A 355
HIS A 299
 None
 1.00A 2qd3A-2e0xA:
undetectable		 2qd3A-2e0xA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP B 398
 None
 1.08A 2yvlB-2e0xA:
undetectable		 2yvlB-2e0xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP B 398
 None
 1.10A 2yvlC-2e0xA:
undetectable		 2yvlC-2e0xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 THR A 163
GLY A  70
ALA A  78
VAL A 169
ASP B 398
 None
 1.09A 2yvlD-2e0xA:
undetectable		 2yvlD-2e0xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 THR B 475
ALA A  52
THR A  59
VAL A  63
LEU A  66
 None
 1.12A 3a51E-2e0xB:
undetectable		 3a51E-2e0xB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		3 / 3 PRO A 133
LEU A 127
ARG A 123
 None
 0.91A 3aqiA-2e0xA:
undetectable		 3aqiA-2e0xA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		4 / 6 GLY A  95
TYR B 408
GLY A 149
ASN A  92
 None
 1.03A 3e9rA-2e0xA:
undetectable		 3e9rA-2e0xA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		4 / 6 GLY A  95
TYR B 408
GLY A 149
ASN A  92
 None
 1.08A 3e9rC-2e0xA:
undetectable		 3e9rC-2e0xA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 8 GLY A  62
ALA A  75
ASP A  74
GLY A  80
LEU A  83
 None
 1.37A 3em6A-2e0xA:
undetectable		 3em6A-2e0xA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 LEU B 492
ILE A 300
SER A 295
SER B 485
GLY A 296
 None
 1.28A 3ijxB-2e0xB:
undetectable
3ijxD-2e0xB:
undetectable		 3ijxB-2e0xB:
21.05
3ijxD-2e0xB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 LEU B 492
ILE A 300
SER A 295
SER B 485
GLY A 296
 None
 1.31A 3ik6B-2e0xB:
undetectable
3ik6E-2e0xB:
undetectable		 3ik6B-2e0xB:
21.05
3ik6E-2e0xB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ILE A 300
SER A 295
SER B 485
GLY A 296
LEU B 492
 None
 1.28A 3iluB-2e0xA:
undetectable
3iluE-2e0xA:
undetectable		 3iluB-2e0xA:
21.20
3iluE-2e0xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 GLY B 424
GLY B 417
SER A 205
PHE A 209
ILE B 418
 None
 1.25A 3k13A-2e0xB:
undetectable		 3k13A-2e0xB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 7 LEU A 307
LEU B 492
SER B 498
THR B 479
 None
 0.96A 3lm8B-2e0xA:
undetectable
3lm8D-2e0xA:
undetectable		 3lm8B-2e0xA:
19.02
3lm8D-2e0xA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 THR B 489
GLY A 297
GLY A 296
ASN A 305
VAL A 301
 None
 0.84A 3nk7A-2e0xB:
undetectable		 3nk7A-2e0xB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 VAL B 397
SER A 289
LEU B 477
VAL B 470
THR B 475
 None
 1.18A 3tbgA-2e0xB:
undetectable		 3tbgA-2e0xB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		6 / 12 LEU A 227
ILE B 425
GLY B 421
ASN A 204
ILE A 251
ALA A 252
 None
 1.37A 3uwlB-2e0xA:
undetectable		 3uwlB-2e0xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 TYR A  81
TYR B 408
GLY A 149
GLY A  96
PHE A 154
 None
 1.05A 3vywA-2e0xA:
undetectable		 3vywA-2e0xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 TYR A  81
TYR B 408
GLY A 149
GLY A  96
PHE A 154
 None
 1.06A 3vywD-2e0xA:
undetectable		 3vywD-2e0xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.93A 4fp9A-2e0xA:
undetectable		 4fp9A-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.93A 4fp9C-2e0xA:
undetectable		 4fp9C-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.92A 4fp9D-2e0xA:
undetectable		 4fp9D-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.93A 4fp9F-2e0xA:
undetectable		 4fp9F-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.06A 4fzvA-2e0xA:
undetectable		 4fzvA-2e0xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.94A 4fzvA-2e0xA:
undetectable		 4fzvA-2e0xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 LEU A 231
LEU A  83
PRO A  88
GLN A 224
ALA A 177
 None
 0.99A 4hwkB-2e0xA:
0.0		 4hwkB-2e0xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 LEU A 231
LEU A  83
PRO A  88
GLN A 224
ALA A 177
 None
 1.02A 4hwkC-2e0xA:
0.0		 4hwkC-2e0xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 LEU A 231
LEU A  83
PRO A  88
GLN A 224
ALA A 177
 None
 1.01A 4hwkD-2e0xA:
0.0		 4hwkD-2e0xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		3 / 3 ARG A 102
ASP B 398
ASP A  74
 None
 0.88A 4kicB-2e0xA:
undetectable		 4kicB-2e0xA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 LEU A 383
ARG A 379
ILE A 378
THR A 355
HIS A 299
 None
 1.00A 4mk4A-2e0xA:
undetectable		 4mk4A-2e0xA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ASP B 398
GLY B 401
VAL A  73
ILE A 101
THR A 163
 None
 0.95A 4njvC-2e0xB:
undetectable		 4njvC-2e0xB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 12 ASP B 398
GLY B 401
VAL A  73
ILE A 101
THR A 163
 None
 0.90A 4njvD-2e0xB:
undetectable		 4njvD-2e0xB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 HIS A  87
THR B 391
THR B 413
GLY A  95
THR A 150
 None
 1.38A 4qvqV-2e0xA:
undetectable
4qvqb-2e0xA:
undetectable		 4qvqV-2e0xA:
23.90
4qvqb-2e0xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 HIS A  87
THR B 391
THR B 413
GLY A  95
THR A 150
 None
 1.39A 4qvqH-2e0xA:
undetectable
4qvqN-2e0xA:
undetectable		 4qvqH-2e0xA:
23.90
4qvqN-2e0xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 6 ALA A 157
ILE A  65
ILE A 101
VAL B 396
 None
 0.71A 4r21A-2e0xA:
undetectable		 4r21A-2e0xA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 8 ALA A 235
ILE A 234
ALA A  82
TYR A  81
LEU A  93
 None
 1.03A 4v1fA-2e0xA:
undetectable
4v1fB-2e0xA:
undetectable		 4v1fA-2e0xA:
14.48
4v1fB-2e0xA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 ASP A  74
ASN A  71
VAL A  73
VAL B 404
THR A 109
 None
 1.47A 4yhaC-2e0xA:
undetectable		 4yhaC-2e0xA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 11 THR B 509
THR B 479
ALA B 567
GLY B 566
ALA A  52
 None
 1.10A 5bxnV-2e0xB:
undetectable
5bxnW-2e0xB:
3.9		 5bxnV-2e0xB:
23.17
5bxnW-2e0xB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		3 / 3 MET B 550
HIS B 515
GLY B 484
 None
 0.77A 5gwzB-2e0xB:
undetectable		 5gwzB-2e0xB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		5 / 10 ALA A 228
LEU A 227
LEU A  93
GLU A 232
ILE A 247
 None
 1.11A 5v02B-2e0xA:
undetectable
5v02R-2e0xA:
undetectable		 5v02B-2e0xA:
14.66
5v02R-2e0xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 5 GLN A 324
THR B 489
HIS B 515
LEU B 523
 None
 1.12A 6aphA-2e0xA:
undetectable		 6aphA-2e0xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli) 		4 / 5 GLN A 324
THR B 489
HIS B 515
LEU B 523
 None
 1.04A 6gbnB-2e0xA:
undetectable		 6gbnB-2e0xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU A 227
GLY B 421
ASN A 204
ILE A 251
ALA A 252
 None
 1.28A 6qxsD-2e0xA:
undetectable		 6qxsD-2e0xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU A 227
ILE B 425
GLY B 421
ASN A 204
ALA A 252
 None
 1.26A 6qxsD-2e0xA:
undetectable		 6qxsD-2e0xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU A 227
GLY B 421
ASN A 204
ILE A 251
ALA A 252
 None
 1.27A 6qyaD-2e0xA:
undetectable		 6qyaD-2e0xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU A 227
ILE B 425
GLY B 421
ASN A 204
ALA A 252
 None
 1.25A 6qyaD-2e0xA:
undetectable		 6qyaD-2e0xA:
23.10