SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		5 / 10 THR A 299
ALA A 297
PHE A 247
ASN A 337
ALA A 301
 None
 1.10A 1claA-2e0zA:
undetectable		 1claA-2e0zA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		5 / 12 VAL A 311
ILE A 331
ILE A 205
ASN A 287
SER A 129
 None
 1.11A 1fm4A-2e0zA:
undetectable		 1fm4A-2e0zA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		3 / 3 PHE A 296
LEU A 134
LEU A 130
 None
 0.50A 1mx1E-2e0zA:
undetectable		 1mx1E-2e0zA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		5 / 10 LEU A 270
LEU A 274
LEU A 249
LEU A 259
ARG A 255
 None
 1.11A 2xn7A-2e0zA:
undetectable
2xn7B-2e0zA:
undetectable		 2xn7A-2e0zA:
22.98
2xn7B-2e0zA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		4 / 8 VAL A 204
LEU A 130
LEU A 134
ILE A 294
 None
 0.91A 3u5kC-2e0zA:
undetectable		 3u5kC-2e0zA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		5 / 12 VAL A 311
ILE A 331
VAL A 204
ILE A 205
ASN A 287
 None
 1.24A 4a84A-2e0zA:
undetectable		 4a84A-2e0zA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		4 / 5 VAL A 204
LEU A 130
LEU A 134
ILE A 294
 None
 0.94A 4a9jA-2e0zA:
undetectable		 4a9jA-2e0zA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		4 / 5 VAL A 204
LEU A 130
LEU A 134
ILE A 294
 None
 0.93A 4a9jB-2e0zA:
undetectable		 4a9jB-2e0zA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		4 / 6 ARG A 138
GLU A 329
LEU A 131
ASP A 310
 None
 1.14A 4cevA-2e0zA:
undetectable
4cevB-2e0zA:
undetectable		 4cevA-2e0zA:
23.81
4cevB-2e0zA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		4 / 6 ASP A 310
ARG A 138
GLU A 329
LEU A 131
 None
 1.13A 4cevA-2e0zA:
undetectable
4cevC-2e0zA:
undetectable		 4cevA-2e0zA:
23.81
4cevC-2e0zA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		4 / 6 ARG A 138
GLU A 329
LEU A 131
ASP A 310
 None
 1.11A 4cevD-2e0zA:
undetectable
4cevE-2e0zA:
undetectable		 4cevD-2e0zA:
23.81
4cevE-2e0zA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		4 / 6 ARG A 138
GLU A 329
LEU A 131
ASP A 310
 None
 1.12A 4cevE-2e0zA:
undetectable
4cevF-2e0zA:
undetectable		 4cevE-2e0zA:
23.81
4cevF-2e0zA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		5 / 12 ILE A 250
LEU A 286
GLY A 127
SER A 129
LEU A 134
 None
 0.86A 4o1zA-2e0zA:
undetectable		 4o1zA-2e0zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2e0z VIRUS-LIKE PARTICLE
(Pyrococcus
furiosus) 		3 / 3 ARG A 255
PHE A 247
LEU A 274
 None
 0.82A 5veuA-2e0zA:
undetectable		 5veuA-2e0zA:
23.63