SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_A_ACTA703_0
(FUMARATE REDUCTASE
FLAVOPROTEIN)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		4 / 4 PHE A  49
ASP A 207
ARG A 203
GLU A  43
 CAC  A1266 (-3.3A)
None
None
CAC  A1266 (-3.2A)
 1.32A 1kf6A-2e11A:
0.6		 1kf6A-2e11A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		4 / 6 PHE A  49
ARG A 203
ASN A  21
LEU A  32
 CAC  A1266 (-3.3A)
None
None
None
 1.10A 2nyrA-2e11A:
undetectable		 2nyrA-2e11A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		4 / 8 LEU A 168
LEU A 170
ALA A 191
LEU A 187
 None
 0.79A 2vcvF-2e11A:
undetectable		 2vcvF-2e11A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		5 / 12 THR A 239
VAL A 219
PHE A 197
TRP A 136
GLN A 227
 None
 1.27A 2x2iA-2e11A:
undetectable		 2x2iA-2e11A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		5 / 10 THR A 239
VAL A 219
PHE A 197
TRP A 136
GLN A 227
 None
 1.26A 2x2iB-2e11A:
0.2		 2x2iB-2e11A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		4 / 8 GLY A  76
ALA A  77
ASP A  37
ILE A  79
 None
 0.66A 3el0A-2e11A:
undetectable		 3el0A-2e11A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		3 / 3 ARG A 179
ASP A 207
GLN A  84
 None
 0.73A 3lcvB-2e11A:
undetectable		 3lcvB-2e11A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		3 / 3 PHE A  45
VAL A  83
GLU A  58
 None
 0.69A 4fvqA-2e11A:
undetectable		 4fvqA-2e11A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		5 / 12 LEU A  38
LEU A  41
ALA A  98
LEU A  96
LEU A  95
 None
 0.84A 4m11B-2e11A:
undetectable		 4m11B-2e11A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		5 / 12 ALA A  77
LEU A 170
PRO A 140
LEU A 168
ILE A   6
 None
 1.03A 4m2xC-2e11A:
undetectable		 4m2xC-2e11A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		5 / 12 ALA A  77
LEU A 170
PRO A 140
LEU A 168
ILE A   6
 None
 1.07A 4m2xE-2e11A:
undetectable		 4m2xE-2e11A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		4 / 8 ILE A   6
LEU A  95
LEU A 129
ILE A 138
 None
 0.91A 4xtaB-2e11A:
undetectable		 4xtaB-2e11A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		4 / 7 GLY A 259
PHE A 156
ARG A 190
ASP A 258
 None
 0.98A 5n5dB-2e11A:
undetectable		 5n5dB-2e11A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2e11 HYDROLASE
(Xanthomonas
campestris) 		5 / 12 ARG A 179
PHE A 171
PHE A 113
ALA A 218
ALA A 214
 None
None
CAC  A1266 (-3.6A)
None
None
 1.04A 5veuA-2e11A:
undetectable		 5veuA-2e11A:
20.33