SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 203
SER A 196
LEU A 193
THR A 137
ILE A 235
 None
 1.22A 1pkvA-2e18A:
undetectable
1pkvB-2e18A:
undetectable		 1pkvA-2e18A:
18.68
1pkvB-2e18A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 167
SER A 196
TYR A 197
 None
 0.78A 1x70A-2e18A:
2.4		 1x70A-2e18A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 120
LEU A 122
ALA A 119
LEU A  54
MET A  56
 None
 1.28A 2aa5A-2e18A:
undetectable		 2aa5A-2e18A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 120
LEU A 122
ALA A 119
LEU A  54
MET A  56
 None
 1.29A 2aa6A-2e18A:
undetectable		 2aa6A-2e18A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A  40
LEU A  41
GLY A  28
ILE A 174
 None
 0.84A 3jusB-2e18A:
undetectable		 3jusB-2e18A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  31
VAL A  51
GLY A  28
SER A  35
ALA A  42
 None
 1.10A 3keeB-2e18A:
undetectable		 3keeB-2e18A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A  40
VAL A 126
VAL A  51
ARG A 111
 None
 1.02A 3pyyA-2e18A:
undetectable		 3pyyA-2e18A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 197
VAL A 161
ILE A 153
ASN A 131
 None
None
None
ZN  A1305 ( 4.9A)
 0.99A 4a97C-2e18A:
undetectable		 4a97C-2e18A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 197
VAL A 161
ILE A 153
ASN A 131
 None
None
None
ZN  A1305 ( 4.9A)
 0.98A 4a97I-2e18A:
undetectable		 4a97I-2e18A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ASN A 198
GLU A 160
TYR A 157
GLU A 202
 None
None
None
ZN  A1304 ( 2.2A)
 1.08A 4mi4A-2e18A:
undetectable		 4mi4A-2e18A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ASN A 198
GLU A 160
TYR A 157
GLU A 202
 None
None
None
ZN  A1304 ( 2.2A)
 1.09A 4mi4A-2e18A:
undetectable
4mi4C-2e18A:
undetectable		 4mi4A-2e18A:
23.10
4mi4C-2e18A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 195
GLY A 194
PHE A 135
ASP A 189
 None
 1.13A 5hieA-2e18A:
undetectable		 5hieA-2e18A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 153
ILE A 125
LEU A 127
VAL A  38
ILE A  17
 None
 1.09A 5mugA-2e18A:
undetectable		 5mugA-2e18A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 161
LEU A  74
PRO A 152
GLY A 128
LEU A 127
 None
 1.14A 5ogcB-2e18A:
undetectable		 5ogcB-2e18A:
19.30