SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 SER A 123
GLY A 101
HIS A 103
ILE A  98
 ZN  A 300 ( 4.9A)
None
ZN  A 300 (-4.4A)
None
 0.86A 1gtnJ-2e1bA:
undetectable
1gtnK-2e1bA:
undetectable		 1gtnJ-2e1bA:
18.18
1gtnK-2e1bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A  62
ASN A  66
TRP A  68
ARG A  26
 None
 1.21A 1rqpB-2e1bA:
3.0		 1rqpB-2e1bA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 HIS A 103
HIS A  99
THR A 100
ILE A 190
THR A 172
 ZN  A 300 (-4.4A)
ZN  A 300 (-3.9A)
None
None
None
 1.23A 1utdQ-2e1bA:
undetectable
1utdR-2e1bA:
undetectable		 1utdQ-2e1bA:
18.18
1utdR-2e1bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 215
GLY A 194
HIS A 195
ILE A 196
 None
 0.95A 1xf1A-2e1bA:
undetectable		 1xf1A-2e1bA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A   8
LEU A  32
MET A   4
THR A 185
 None
 1.40A 2oaxD-2e1bA:
undetectable		 2oaxD-2e1bA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A  62
ASN A  66
TRP A  68
ARG A  26
 None
 1.25A 2v7uB-2e1bA:
3.1		 2v7uB-2e1bA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 HIS A  99
HIS A 103
ARG A 170
HIS A 186
 ZN  A 300 (-3.9A)
ZN  A 300 (-4.4A)
None
None
 1.12A 3nvcA-2e1bA:
undetectable		 3nvcA-2e1bA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A  36
MET A   4
ASN A   3
PHE A  37
 None
 1.25A 3octA-2e1bA:
undetectable		 3octA-2e1bA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A 154
HIS A 107
ARG A 175
 None
 0.84A 4e7bC-2e1bA:
undetectable		 4e7bC-2e1bA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A 201
LYS A 144
ILE A 147
LEU A 113
 None
 1.06A 4em2A-2e1bA:
0.9		 4em2A-2e1bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 133
TRP A 214
SER A 202
 None
 0.99A 4lrhB-2e1bA:
undetectable		 4lrhB-2e1bA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 133
TRP A 214
SER A 202
 None
 1.07A 4lrhF-2e1bA:
undetectable		 4lrhF-2e1bA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 175
LYS A 153
GLU A 157
 None
 0.79A 5d0yA-2e1bA:
undetectable		 5d0yA-2e1bA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  98
LEU A  95
SER A 123
GLY A 130
GLY A 124
 None
None
ZN  A 300 ( 4.9A)
None
None
 1.10A 5nnaA-2e1bA:
undetectable		 5nnaA-2e1bA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  98
LEU A  95
SER A 123
GLY A 130
GLY A 124
 None
None
ZN  A 300 ( 4.9A)
None
None
 1.08A 5nnaB-2e1bA:
undetectable		 5nnaB-2e1bA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  98
LEU A  95
SER A 123
GLY A 130
GLY A 124
 None
None
ZN  A 300 ( 4.9A)
None
None
 1.11A 5nnaC-2e1bA:
undetectable		 5nnaC-2e1bA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  98
LEU A  95
SER A 123
GLY A 130
GLY A 124
 None
None
ZN  A 300 ( 4.9A)
None
None
 1.11A 5nnaD-2e1bA:
undetectable		 5nnaD-2e1bA:
21.63