SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2e1d TRANSALDOLASE
(Mus
musculus) 		5 / 12 ASP A 137
GLY A 101
ILE A  99
THR A 105
ILE A 139
 None
 1.06A 1c6zA-2e1dA:
undetectable		 1c6zA-2e1dA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 4 LYS A  86
LEU A  90
ALA A  65
LEU A  61
 None
 1.39A 1f86A-2e1dA:
0.0		 1f86A-2e1dA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 4 LYS A  86
LEU A  90
ALA A  65
LEU A  61
 None
 1.07A 1f86B-2e1dA:
undetectable		 1f86B-2e1dA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2e1d TRANSALDOLASE
(Mus
musculus) 		5 / 12 LEU A 125
LEU A 128
ALA A 132
LEU A  87
THR A 105
 None
 1.08A 1ya3C-2e1dA:
undetectable		 1ya3C-2e1dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 2e1d TRANSALDOLASE
(Mus
musculus) 		5 / 12 LEU A 156
GLY A 153
THR A 231
MET A 166
ILE A 186
 None
 1.41A 1z95A-2e1dA:
0.0		 1z95A-2e1dA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 5 PRO A  56
ALA A  57
ASP A 318
ASP A  30
 None
 1.17A 2nyuB-2e1dA:
undetectable		 2nyuB-2e1dA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 6 ASP A 108
LEU A 322
ASP A  85
LEU A 128
 None
 1.22A 3bj8C-2e1dA:
undetectable
3bj8D-2e1dA:
undetectable		 3bj8C-2e1dA:
22.29
3bj8D-2e1dA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2e1d TRANSALDOLASE
(Mus
musculus) 		3 / 3 ASP A 318
ARG A 192
LYS A 314
 None
SO3  A3016 (-4.0A)
None
 1.17A 3wipG-2e1dA:
undetectable		 3wipG-2e1dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2e1d TRANSALDOLASE
(Mus
musculus) 		3 / 3 LEU A 270
GLU A  12
SER A 268
 None
 0.82A 4ccqA-2e1dA:
2.0		 4ccqA-2e1dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 4 LEU A 247
ILE A 244
GLY A 235
ILE A 255
 None
 0.82A 5dzk3-2e1dA:
undetectable
5dzkm-2e1dA:
undetectable		 5dzk3-2e1dA:
0.78
5dzkm-2e1dA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 5 ILE A 244
GLY A 235
ILE A 255
LEU A 247
 None
 0.85A 5dzkB-2e1dA:
2.3
5dzkI-2e1dA:
undetectable
5dzkW-2e1dA:
undetectable		 5dzkB-2e1dA:
21.25
5dzkI-2e1dA:
20.59
5dzkW-2e1dA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 5 ILE A 244
GLY A 235
ILE A 255
LEU A 247
 None
 0.85A 5dzki-2e1dA:
undetectable
5dzkj-2e1dA:
undetectable
5dzkx-2e1dA:
undetectable		 5dzki-2e1dA:
20.59
5dzkj-2e1dA:
20.59
5dzkx-2e1dA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 5 ILE A 244
GLY A 235
ILE A 255
LEU A 247
 None
 0.82A 5dzkd-2e1dA:
undetectable
5dzkk-2e1dA:
undetectable
5dzky-2e1dA:
undetectable		 5dzkd-2e1dA:
21.25
5dzkk-2e1dA:
20.59
5dzky-2e1dA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2e1d TRANSALDOLASE
(Mus
musculus) 		4 / 4 ILE A 244
GLY A 235
ILE A 255
LEU A 247
 None
 0.84A 5dzkl-2e1dA:
undetectable
5dzkz-2e1dA:
undetectable		 5dzkl-2e1dA:
20.59
5dzkz-2e1dA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2e1d TRANSALDOLASE
(Mus
musculus) 		5 / 12 GLY A  92
PHE A 238
ILE A 244
GLY A 235
THR A 105
 None
 1.26A 5eslA-2e1dA:
0.4		 5eslA-2e1dA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2e1d TRANSALDOLASE
(Mus
musculus) 		5 / 12 LEU A 270
GLY A 235
ALA A 248
LEU A  18
GLY A 213
 None
 1.01A 5kb5A-2e1dA:
undetectable		 5kb5A-2e1dA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2e1d TRANSALDOLASE
(Mus
musculus) 		5 / 12 ASN A  82
GLY A  69
ASP A  85
PHE A 331
ILE A  84
 None
 1.16A 5vooF-2e1dA:
6.9		 5vooF-2e1dA:
23.73