SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e1m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 8 MET A 354
LEU A  62
ALA B 401
VAL C 640
None
0.78A 1epbB-2e1mA:
undetectable
1epbB-2e1mA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 10 VAL A 384
PHE B 419
VAL C 640
VAL B 415
VAL B 413
None
1.20A 1fe2A-2e1mA:
undetectable
1fe2A-2e1mA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
5 / 12 HIS C 651
GLY C 644
GLU C 645
GLY C 656
VAL B 403
None
FAD  A 801 (-3.0A)
FAD  A 801 (-4.7A)
None
None
1.09A 1n2xA-2e1mC:
undetectable
1n2xA-2e1mC:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 4 ALA A  69
VAL C 658
ALA C 657
HIS C 646
FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.6A)
None
1.13A 1q23A-2e1mA:
undetectable
1q23A-2e1mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 4 ALA A  69
VAL C 658
ALA C 657
HIS C 646
FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.6A)
None
1.24A 1q23F-2e1mA:
undetectable
1q23F-2e1mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 4 ALA A  69
VAL C 658
ALA C 657
HIS C 646
FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.6A)
None
1.06A 1q23K-2e1mA:
undetectable
1q23K-2e1mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 12 ILE A  98
LEU A 336
VAL C 658
GLY A  67
ALA A  66
FAD  A 801 (-4.8A)
None
None
FAD  A 801 (-3.4A)
None
1.10A 1r9oA-2e1mA:
undetectable
1r9oA-2e1mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
3 / 3 ASP A 250
VAL A 255
PRO A 258
None
0.68A 2avvA-2e1mA:
undetectable
2avvA-2e1mA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 10 SER B 443
PHE B 442
LEU C 584
GLY C 592
THR C 600
None
1.40A 2b8jB-2e1mB:
undetectable
2b8jB-2e1mB:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 11 ALA C 561
ALA C 583
LEU B 440
LEU C 559
VAL C 558
None
1.13A 2bxeB-2e1mC:
undetectable
2bxeB-2e1mC:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 8 VAL A  72
VAL C 658
LEU A  71
PRO A 337
None
0.94A 2ddwA-2e1mA:
undetectable
2ddwA-2e1mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 8 VAL C 633
VAL B 427
ALA C 619
ARG A  97
None
None
None
FAD  A 801 (-3.7A)
1.10A 2ij7C-2e1mC:
undetectable
2ij7C-2e1mC:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 8 ALA C 661
VAL A  72
LEU A 131
THR A 132
None
0.90A 2it4A-2e1mC:
undetectable
2it4A-2e1mC:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 11 ALA A  89
GLY A  95
GLU A  88
GLY A  65
ILE B 405
FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.0A)
FAD  A 801 (-3.4A)
FAD  A 801 (-3.2A)
1.02A 2x1lC-2e1mA:
undetectable
2x1lC-2e1mA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
3 / 3 VAL A 255
TRP A 266
TRP A 262
None
1.40A 2xdcC-2e1mA:
undetectable
2xdcD-2e1mA:
undetectable
2xdcC-2e1mA:
4.90
2xdcD-2e1mA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
5 / 9 ALA C 643
GLY A  70
GLY A  67
ILE C 654
ALA C 661
None
None
FAD  A 801 (-3.4A)
FAD  A 801 (-3.9A)
None
0.95A 2z0yA-2e1mC:
undetectable
2z0yA-2e1mC:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
5 / 12 LEU C 649
PHE C 642
GLY C 644
ILE B 405
PHE B 419
None
None
FAD  A 801 (-3.0A)
FAD  A 801 (-3.2A)
None
1.25A 2zznB-2e1mC:
undetectable
2zznB-2e1mC:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 4 GLU A 294
GLY A 297
THR A 298
GLU A 300
None
1.10A 3e9xA-2e1mA:
undetectable
3e9xA-2e1mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
4 / 5 PRO C 612
THR B 404
VAL A  64
GLY A  65
None
None
None
FAD  A 801 (-3.4A)
1.18A 3elzA-2e1mC:
undetectable
3elzA-2e1mC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
3 / 3 ARG A 144
THR A 132
THR A 100
None
0.61A 3k2hB-2e1mA:
undetectable
3k2hB-2e1mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 10 ILE A  48
ILE A  98
LEU A 336
ILE A 348
ILE A  63
None
FAD  A 801 (-4.8A)
None
None
None
1.23A 3prsA-2e1mA:
undetectable
3prsA-2e1mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 4 LEU A 133
ILE A 320
TYR A 167
TYR A 326
None
1.42A 3vt7A-2e1mA:
undetectable
3vt7A-2e1mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
3 / 3 VAL A 247
TRP A 266
TRP A 262
None
1.25A 3zq8A-2e1mA:
undetectable
3zq8B-2e1mA:
undetectable
3zq8A-2e1mA:
4.90
3zq8B-2e1mA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 12 LEU A 340
ALA C 665
ILE A  68
GLY A  70
GLY A  65
None
None
FAD  A 801 (-4.7A)
None
FAD  A 801 (-3.4A)
1.16A 4hfpB-2e1mA:
undetectable
4hfpB-2e1mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
3 / 3 TYR C 530
HIS A 193
ARG A 191
None
1.01A 4htfA-2e1mC:
undetectable
4htfA-2e1mC:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 12 LEU A  29
VAL C 662
LEU A 131
THR A 132
PRO A 130
None
1.03A 4k0zA-2e1mA:
undetectable
4k0zA-2e1mA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 12 ALA A  73
ILE B 405
GLY C 644
ALA C 643
ALA B 401
None
FAD  A 801 (-3.2A)
FAD  A 801 (-3.0A)
None
None
0.96A 4nkxB-2e1mA:
undetectable
4nkxB-2e1mA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
5 / 9 ALA C 561
ALA C 583
LEU B 440
LEU C 559
VAL C 558
None
1.10A 4or0B-2e1mC:
undetectable
4or0B-2e1mC:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
3 / 3 ASP B 453
ARG A 204
ARG A 191
None
0.97A 5eajB-2e1mB:
undetectable
5eajB-2e1mB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
2e1m L-GLUTAMATE OXIDASE
(Streptomyces
sp.
X-119-6)
4 / 6 ALA C 560
VAL C 558
TYR C 545
VAL C 590
None
1.05A 5eckD-2e1mC:
undetectable
5eckD-2e1mC:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
5 / 12 ALA A 341
GLY A  70
ARG C 663
ALA C 643
ALA A  73
None
1.12A 5n5dA-2e1mA:
undetectable
5n5dA-2e1mA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
4 / 6 LEU A  76
VAL A  72
LEU A 340
VAL C 658
None
0.81A 5x7zA-2e1mA:
undetectable
5x7zA-2e1mA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
4 / 4 HIS C 630
LEU A  29
TYR A  43
GLY C 656
None
1.44A 6n91A-2e1mC:
undetectable
6n91A-2e1mC:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)
2e1m L-GLUTAMATE OXIDASE
L-GLUTAMATE OXIDASE

(Streptomyces
sp.
X-119-6;
Streptomyces
sp.
X-119-6)
4 / 4 HIS C 630
LEU A  29
TYR A  43
GLY C 656
None
1.45A 6n91B-2e1mC:
undetectable
6n91B-2e1mC:
22.07