SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		5 / 9 ASP A  33
VAL A 321
GLY A 173
CYH A 171
GLY A 318
 None
MLC  A1001 ( 4.9A)
None
None
None
 1.37A 1bcuH-2e1tA:
undetectable		 1bcuH-2e1tA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		4 / 8 GLY A 449
GLY A 338
PHE A 339
SER A 285
 None
 0.74A 1d0vA-2e1tA:
undetectable		 1d0vA-2e1tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		4 / 8 GLY A 449
GLY A 338
PHE A 339
SER A 285
 None
 0.72A 1jhaA-2e1tA:
undetectable		 1jhaA-2e1tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		4 / 8 GLY A 449
GLY A 338
PHE A 339
SER A 285
 None
 0.75A 1jhvA-2e1tA:
undetectable		 1jhvA-2e1tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		4 / 6 VAL A  80
LEU A  22
PHE A  76
HIS A  75
 None
 1.11A 2f8dA-2e1tA:
undetectable		 2f8dA-2e1tA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		4 / 6 GLY A 318
TYR A 207
ASP A 174
ASN A 319
 None
 1.24A 2g72A-2e1tA:
undetectable		 2g72A-2e1tA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		3 / 3 GLY A 100
ASP A 101
SER A  16
 None
 0.64A 2qhfA-2e1tA:
undetectable		 2qhfA-2e1tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		5 / 12 ALA A 108
LEU A 131
LEU A 114
ILE A 162
THR A 106
 None
 1.09A 2w3vA-2e1tA:
undetectable		 2w3vA-2e1tA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		5 / 12 LEU A 114
GLY A 161
TRP A 399
LEU A 405
VAL A  61
 None
 1.35A 2w8yA-2e1tA:
undetectable		 2w8yA-2e1tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		3 / 3 ARG A 178
GLU A 429
SER A 176
 MLC  A1001 (-3.7A)
None
None
 0.94A 2xkkA-2e1tA:
undetectable
2xkkC-2e1tA:
undetectable		 2xkkA-2e1tA:
20.03
2xkkC-2e1tA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		4 / 6 VAL A 321
SER A 385
LEU A 297
ILE A 416
 MLC  A1001 ( 4.9A)
MLC  A1001 ( 4.0A)
None
None
 0.96A 3kk6A-2e1tA:
undetectable		 3kk6A-2e1tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		4 / 7 LEU A 114
GLY A 165
ILE A 164
THR A 118
 None
 0.86A 3spkB-2e1tA:
undetectable		 3spkB-2e1tA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		5 / 12 ASP A  33
GLY A 318
PHE A  32
GLY A 322
ASP A 303
 None
None
None
None
MLC  A1001 (-4.8A)
 1.36A 4pevB-2e1tA:
undetectable		 4pevB-2e1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		5 / 11 LEU A 345
GLN A 296
ALA A 328
THR A 382
ILE A 416
 None
 1.17A 4uuuB-2e1tA:
undetectable		 4uuuB-2e1tA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		3 / 3 LYS A 183
LEU A  69
ILE A 166
 None
 0.73A 5kc0A-2e1tA:
undetectable		 5kc0A-2e1tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		3 / 3 LYS A 183
LEU A  69
ILE A 166
 None
 0.81A 5kc4A-2e1tA:
undetectable		 5kc4A-2e1tA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2e1t ACYL TRANSFERASE
(Chrysanthemum
x
morifolium) 		5 / 12 LEU A  37
LEU A  29
ARG A 209
PRO A  78
ILE A  95
 None
 1.38A 5uahC-2e1tA:
0.2		 5uahC-2e1tA:
16.62