SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		6 / 12 TYR L  36
PHE L  98
TRP H  33
VAL H  37
ALA H  93
TRP H 103
 None
None
AB0  H6001 (-3.7A)
None
None
None
 0.80A 1h8sA-2e27L:
20.6		 1h8sA-2e27L:
26.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		4 / 8 TYR L  36
TYR L  49
LEU L  89
TRP L  96
 None
AB0  H6001 (-4.6A)
None
AB0  H6001 (-4.2A)
 0.67A 1i7zA-2e27L:
21.0		 1i7zA-2e27L:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		5 / 10 GLY H1002
ALA L  34
TYR L  36
LEU L  46
TYR L  49
 None
AB0  H6001 ( 4.0A)
None
AB0  H6001 ( 4.9A)
AB0  H6001 (-4.6A)
 0.57A 1jglH-2e27H:
19.9
1jglL-2e27H:
16.2		 1jglH-2e27H:
27.98
1jglL-2e27H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 7 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.09A 1usqA-2e27H:
undetectable		 1usqA-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  53
PRO H 521
ILE H  51
GLY H  55
 None
 0.79A 1usqB-2e27H:
undetectable		 1usqB-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  53
PRO H 521
ILE H  51
GLY H  55
 None
 0.79A 1usqC-2e27H:
undetectable		 1usqC-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  53
PRO H 521
ILE H  51
GLY H  55
 None
 0.79A 1usqD-2e27H:
undetectable		 1usqD-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  53
PRO H 521
ILE H  51
GLY H  55
 None
 0.79A 1usqE-2e27H:
undetectable		 1usqE-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 7 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.08A 1usqF-2e27H:
undetectable		 1usqF-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  53
PRO H 521
ILE H  51
GLY H  55
 None
 0.85A 2jkjA-2e27H:
undetectable		 2jkjA-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  53
PRO H 521
ILE H  51
GLY H  55
 None
 0.85A 2jkjB-2e27H:
undetectable		 2jkjB-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  53
PRO H 521
ILE H  51
GLY H  55
 None
 0.86A 2jkjC-2e27H:
undetectable		 2jkjC-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 7 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 2jkjE-2e27H:
undetectable		 2jkjE-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 7 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 2jklA-2e27H:
undetectable		 2jklA-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  53
PRO H 521
ILE H  51
GLY H  55
 None
 0.85A 2jklB-2e27H:
undetectable		 2jklB-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 7 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 2jklC-2e27H:
undetectable		 2jklC-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 7 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.10A 2jklD-2e27H:
undetectable		 2jklD-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 7 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 2jklE-2e27H:
undetectable		 2jklE-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 7 GLY H  53
PRO H 521
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 2jklF-2e27H:
undetectable		 2jklF-2e27H:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 7 TYR L  36
HIS L  38
PRO L  44
TYR L  87
TYR H  91
 None
 0.75A 2oldA-2e27L:
18.6
2oldB-2e27L:
18.1		 2oldA-2e27L:
25.34
2oldB-2e27L:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		4 / 7 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.65A 2ombC-2e27L:
18.4
2ombD-2e27L:
18.1		 2ombC-2e27L:
25.34
2ombD-2e27L:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 7 TYR L  36
HIS L  38
PRO L  44
TYR H  91
 None
 0.99A 2ombC-2e27L:
18.4
2ombD-2e27L:
18.1		 2ombC-2e27L:
25.34
2ombD-2e27L:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		3 / 3 ASP H 100
TYR L  49
LYS L  55
 None
AB0  H6001 (-4.6A)
None
 1.22A 2othA-2e27H:
undetectable		 2othA-2e27H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		3 / 3 ILE L  48
SER L  74
SER L  72
 None
GOL  L5001 (-2.7A)
GOL  L5001 ( 4.4A)
 0.56A 3iltH-2e27L:
undetectable		 3iltH-2e27L:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		5 / 10 ILE H  48
SER H 113
ALA H  16
LEU H 823
ALA H  83
 None
 1.41A 3lw5B-2e27H:
undetectable		 3lw5B-2e27H:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		4 / 6 GLN L  37
TYR L  86
GLN L   6
ILE L  21
 None
 1.31A 3peoG-2e27L:
undetectable		 3peoG-2e27L:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		5 / 8 LYS L 107
ALA L  13
GLY L  17
LEU L  78
LEU L 104
 None
 1.45A 4po0A-2e27L:
undetectable		 4po0A-2e27L:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2O_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		4 / 5 GLN L  27
THR L  95
ASP L  92
ASN L  93
 None
 1.26A 5b2oA-2e27L:
0.0		 5b2oA-2e27L:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2P_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		4 / 5 GLN L  27
THR L  95
ASP L  92
ASN L  93
 None
 1.25A 5b2pA-2e27L:
0.0		 5b2pA-2e27L:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1729_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN
(Mus
musculus) 		4 / 5 GLN L  27
THR L  95
ASP L  92
ASN L  93
 None
 1.25A 5b2qA-2e27L:
0.0		 5b2qA-2e27L:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 LEU H 823
ALA H  12
SER H  87
THR H 107
 None
None
GOL  H5002 ( 4.3A)
None
 0.90A 6f88A-2e27H:
undetectable		 6f88A-2e27H:
16.92