SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 8 GLU A 225
ILE A 143
LEU A 112
ALA A 120
VAL A 133
 None
 1.47A 1a29A-2e28A:
undetectable		 1a29A-2e28A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 517
GLY A 546
ALA A 528
ILE A 551
 None
 0.75A 1c9sI-2e28A:
undetectable
1c9sJ-2e28A:
undetectable		 1c9sI-2e28A:
9.86
1c9sJ-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.75A 1c9sU-2e28A:
undetectable
1c9sV-2e28A:
undetectable		 1c9sU-2e28A:
9.86
1c9sV-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.01A 1dfoA-2e28A:
undetectable		 1dfoA-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.01A 1dfoB-2e28A:
undetectable		 1dfoB-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.01A 1dfoC-2e28A:
undetectable		 1dfoC-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.01A 1dfoD-2e28A:
undetectable		 1dfoD-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.00A 1eqbA-2e28A:
undetectable		 1eqbA-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.01A 1eqbB-2e28A:
undetectable		 1eqbB-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.00A 1eqbC-2e28A:
undetectable		 1eqbC-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.00A 1eqbD-2e28A:
undetectable		 1eqbD-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.71A 1gtnA-2e28A:
undetectable
1gtnK-2e28A:
undetectable		 1gtnA-2e28A:
9.86
1gtnK-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 517
GLY A 546
ALA A 528
ILE A 551
 None
 0.73A 1gtnA-2e28A:
undetectable
1gtnB-2e28A:
undetectable		 1gtnA-2e28A:
9.86
1gtnB-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 517
GLY A 546
ALA A 528
ILE A 551
 None
 0.72A 1gtnE-2e28A:
undetectable
1gtnF-2e28A:
undetectable		 1gtnE-2e28A:
9.86
1gtnF-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 517
GLY A 546
ALA A 528
ILE A 551
 None
 0.73A 1gtnI-2e28A:
undetectable
1gtnJ-2e28A:
undetectable		 1gtnI-2e28A:
9.86
1gtnJ-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.78A 1gtnP-2e28A:
undetectable
1gtnQ-2e28A:
undetectable		 1gtnP-2e28A:
9.86
1gtnQ-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 213
ASP A 178
ILE A 179
ILE A 171
 None
 0.92A 1p7lD-2e28A:
undetectable		 1p7lD-2e28A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 213
ASP A 178
ILE A 179
ILE A 171
 None
 0.93A 1p7lC-2e28A:
undetectable		 1p7lC-2e28A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 195
ILE A 222
ILE A 231
ASP A 200
VAL A 201
 None
 0.95A 1qhyA-2e28A:
undetectable		 1qhyA-2e28A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 234
LEU A 235
VAL A 243
GLY A 227
ALA A 229
 None
 1.03A 1r9oA-2e28A:
undetectable		 1r9oA-2e28A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 213
ASP A 178
ILE A 179
ILE A 171
 None
 0.91A 1rg9B-2e28A:
undetectable		 1rg9B-2e28A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 213
ASP A 178
ILE A 179
ILE A 171
 None
 0.92A 1rg9A-2e28A:
undetectable		 1rg9A-2e28A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 213
ASP A 178
ILE A 179
ILE A 171
 None
 0.91A 1rg9D-2e28A:
undetectable		 1rg9D-2e28A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 213
ASP A 178
ILE A 179
ILE A 171
 None
 0.92A 1rg9C-2e28A:
undetectable		 1rg9C-2e28A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 7 MET A  78
ALA A  82
ILE A  83
ILE A 105
 None
 0.92A 1upfB-2e28A:
undetectable		 1upfB-2e28A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.76A 1utdB-2e28A:
undetectable
1utdC-2e28A:
undetectable		 1utdB-2e28A:
9.86
1utdC-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.74A 1utdF-2e28A:
undetectable
1utdG-2e28A:
undetectable		 1utdF-2e28A:
9.86
1utdG-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.73A 1utdI-2e28A:
undetectable
1utdJ-2e28A:
undetectable		 1utdI-2e28A:
9.86
1utdJ-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.72A 1utdJ-2e28A:
undetectable
1utdK-2e28A:
undetectable		 1utdJ-2e28A:
9.86
1utdK-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		3 / 3 MET A 329
ASN A 301
GLN A 261
 None
 1.05A 1xoqB-2e28A:
undetectable		 1xoqB-2e28A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  83
THR A  75
LEU A 124
VAL A 133
THR A 145
 None
 1.06A 2qo5A-2e28A:
undetectable		 2qo5A-2e28A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.02A 2vmyA-2e28A:
undetectable		 2vmyA-2e28A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 4 PRO A 110
THR A 108
GLY A 100
THR A 101
 None
 1.19A 3ib1A-2e28A:
undetectable		 3ib1A-2e28A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 483
ILE A 554
VAL A 545
ALA A 530
ILE A 484
 None
 0.97A 3n3iA-2e28A:
undetectable		 3n3iA-2e28A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 165
ARG A 197
LYS A 267
 None
 1.16A 3okxA-2e28A:
2.6		 3okxA-2e28A:
15.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		8 / 10 THR A  10
PRO A  13
ARG A  33
ASN A  35
HIS A  38
GLY A  39
GLY A 314
ALA A 317
 None
 0.49A 3pp7B-2e28A:
59.4		 3pp7B-2e28A:
38.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 339
ILE A 303
ALA A 302
THR A 277
VAL A 275
 None
 1.25A 3r9cA-2e28A:
undetectable		 3r9cA-2e28A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 536
ILE A 531
THR A 561
VAL A 545
ILE A 525
 None
 0.88A 4q5mA-2e28A:
undetectable		 4q5mA-2e28A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 298
SER A 284
THR A 292
GLU A 315
SER A 313
 None
 1.21A 5hfjD-2e28A:
undetectable		 5hfjD-2e28A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 278
SER A 284
THR A 292
GLU A 315
SER A 313
 None
 1.22A 5hfjE-2e28A:
undetectable		 5hfjE-2e28A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 9 ILE A 332
VAL A 310
THR A   5
ILE A 303
 None
 0.78A 5lg3I-2e28A:
undetectable		 5lg3I-2e28A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 241
ILE A 303
THR A 307
MET A 281
 None
 1.36A 5ljeA-2e28A:
undetectable		 5ljeA-2e28A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 264
ILE A 303
THR A 307
MET A 281
 None
 1.38A 5ljeA-2e28A:
undetectable		 5ljeA-2e28A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  28
VAL A  62
ALA A 333
MET A 329
VAL A 310
 None
 1.01A 5n0tA-2e28A:
undetectable		 5n0tA-2e28A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  28
VAL A  62
ALA A 333
MET A 329
VAL A 310
 None
 1.02A 5n0tB-2e28A:
undetectable		 5n0tB-2e28A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  28
VAL A  62
ALA A 333
MET A 329
VAL A 310
 None
 1.01A 5n0wA-2e28A:
undetectable		 5n0wA-2e28A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  28
VAL A  62
ALA A 333
MET A 329
VAL A 310
 None
 1.01A 5n0wB-2e28A:
2.2		 5n0wB-2e28A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  28
VAL A  62
ALA A 333
MET A 329
VAL A 310
 None
 1.01A 5n0xA-2e28A:
undetectable		 5n0xA-2e28A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  28
VAL A  62
ALA A 333
MET A 329
VAL A 310
 None
 1.02A 5n0xB-2e28A:
undetectable		 5n0xB-2e28A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  28
VAL A  62
ALA A 333
MET A 329
VAL A 310
 None
 1.00A 5n4iA-2e28A:
undetectable		 5n4iA-2e28A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 PRO A 291
ILE A   7
VAL A 299
ILE A 303
THR A 307
 None
 1.20A 5tiwA-2e28A:
undetectable		 5tiwA-2e28A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 SER A 313
GLY A 240
SER A 268
VAL A 243
 None
 0.91A 6giqL-2e28A:
undetectable
6giqP-2e28A:
undetectable
6giqT-2e28A:
undetectable		 6giqL-2e28A:
22.95
6giqP-2e28A:
19.25
6giqT-2e28A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2e28 PYRUVATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A  39
PHE A  36
HIS A  38
GLY A  12
 None
 0.80A 6hu9H-2e28A:
undetectable
6hu9e-2e28A:
undetectable		 6hu9H-2e28A:
8.88
6hu9e-2e28A:
12.93