SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2e2c UBIQUITIN
CONJUGATING ENZYME
(Spisula
solidissima) 		5 / 12 LEU A 132
LEU A 135
LEU A 138
VAL A 107
ILE A  50
 None
 1.07A 1s9pC-2e2cA:
undetectable		 1s9pC-2e2cA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2e2c UBIQUITIN
CONJUGATING ENZYME
(Spisula
solidissima) 		5 / 12 LEU A 135
LEU A  66
PRO A  90
THR A 123
THR A 130
 None
 1.23A 3dcjA-2e2cA:
undetectable
3dcjB-2e2cA:
undetectable		 3dcjA-2e2cA:
21.62
3dcjB-2e2cA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2e2c UBIQUITIN
CONJUGATING ENZYME
(Spisula
solidissima) 		5 / 10 LEU A 132
LEU A  83
ALA A  52
LEU A  35
LEU A  42
 None
 1.08A 4p65A-2e2cA:
undetectable
4p65B-2e2cA:
undetectable
4p65F-2e2cA:
undetectable
4p65H-2e2cA:
undetectable		 4p65A-2e2cA:
9.68
4p65B-2e2cA:
9.15
4p65F-2e2cA:
9.15
4p65H-2e2cA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2e2c UBIQUITIN
CONJUGATING ENZYME
(Spisula
solidissima) 		5 / 11 LEU A 132
LEU A  83
ALA A  52
LEU A  42
LEU A  35
 None
 1.03A 4p65C-2e2cA:
undetectable
4p65D-2e2cA:
undetectable
4p65J-2e2cA:
undetectable
4p65L-2e2cA:
undetectable		 4p65C-2e2cA:
9.68
4p65D-2e2cA:
9.15
4p65J-2e2cA:
9.15
4p65L-2e2cA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2e2c UBIQUITIN
CONJUGATING ENZYME
(Spisula
solidissima) 		5 / 11 LEU A 132
LEU A  83
ALA A  52
LEU A  35
LEU A  42
 None
 0.97A 4p65E-2e2cA:
undetectable
4p65F-2e2cA:
undetectable
4p65J-2e2cA:
undetectable
4p65L-2e2cA:
undetectable		 4p65E-2e2cA:
9.68
4p65F-2e2cA:
9.15
4p65J-2e2cA:
9.15
4p65L-2e2cA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2e2c UBIQUITIN
CONJUGATING ENZYME
(Spisula
solidissima) 		3 / 3 TYR A  79
THR A  65
THR A 100
 None
 0.75A 5aoxB-2e2cA:
undetectable		 5aoxB-2e2cA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2e2c UBIQUITIN
CONJUGATING ENZYME
(Spisula
solidissima) 		3 / 3 TYR A  79
THR A  65
THR A 100
 None
 0.82A 5aoxE-2e2cA:
undetectable		 5aoxE-2e2cA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2e2c UBIQUITIN
CONJUGATING ENZYME
(Spisula
solidissima) 		3 / 3 ARG A  34
PHE A  53
LEU A  59
 None
 0.65A 5veuA-2e2cA:
undetectable		 5veuA-2e2cA:
17.57