SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A 145
ILE A 176
GLY A 148
VAL A 172
SER A 143
 None
 1.35A 1nbhA-2e2nA:
undetectable		 1nbhA-2e2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A 145
ILE A 176
GLY A 148
VAL A 172
SER A 143
 None
 1.36A 1nbhD-2e2nA:
undetectable		 1nbhD-2e2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A 286
ILE A  26
ILE A   4
VAL A 282
ALA A 281
 None
 1.09A 1uduB-2e2nA:
undetectable		 1uduB-2e2nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  29
ALA A  16
ILE A  48
ALA A  60
VAL A   5
 None
 1.04A 2b7zB-2e2nA:
undetectable		 2b7zB-2e2nA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 10 ALA A  55
ALA A  51
ALA A  16
GLY A  58
ALA A  60
 None
 0.97A 2f16K-2e2nA:
undetectable
2f16L-2e2nA:
undetectable		 2f16K-2e2nA:
21.61
2f16L-2e2nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 10 ALA A  55
ALA A  51
ALA A  16
GLY A  58
ALA A  60
 None
 0.97A 2f16Y-2e2nA:
undetectable
2f16Z-2e2nA:
undetectable		 2f16Y-2e2nA:
21.61
2f16Z-2e2nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  27
ASP A  20
ILE A   4
GLY A   6
VAL A   7
 None
 0.91A 2f8gB-2e2nA:
undetectable		 2f8gB-2e2nA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		6 / 12 ALA A   9
ASP A   8
GLY A   6
GLY A  64
ILE A  91
ILE A  48
 None
 1.04A 2fxeA-2e2nA:
undetectable		 2fxeA-2e2nA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  52
THR A  80
VAL A  67
GLY A  66
ALA A   9
 None
 1.06A 2x2iA-2e2nA:
undetectable		 2x2iA-2e2nA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  52
THR A  80
VAL A  67
GLY A  66
ALA A   9
 None
 1.04A 2x2iC-2e2nA:
undetectable		 2x2iC-2e2nA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		4 / 7 VAL A  90
ILE A  86
ALA A  60
GLY A  64
 None
 0.79A 2xrzB-2e2nA:
undetectable		 2xrzB-2e2nA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 153
LEU A 181
ILE A 219
ASP A 218
VAL A 215
 None
 1.16A 2zzmA-2e2nA:
undetectable		 2zzmA-2e2nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 153
LEU A 181
ILE A 219
ASP A 218
VAL A 215
 None
 1.17A 2zznA-2e2nA:
undetectable		 2zznA-2e2nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 280
GLY A  96
LEU A 105
GLU A 103
ILE A 279
 None
 1.03A 3embA-2e2nA:
undetectable		 3embA-2e2nA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A 225
TYR A 262
SER A 229
 None
 0.85A 4at0A-2e2nA:
undetectable		 4at0A-2e2nA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		4 / 6 ARG A 134
GLY A 135
ASN A  35
GLN A 230
 None
 1.26A 4g0vB-2e2nA:
undetectable		 4g0vB-2e2nA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 THR A  80
LEU A  82
ALA A  83
GLY A  69
LEU A  70
 None
 0.99A 4xi3C-2e2nA:
undetectable		 4xi3C-2e2nA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  66
GLY A 248
THR A  12
GLY A  11
GLY A  10
 None
 0.89A 5koxA-2e2nA:
undetectable		 5koxA-2e2nA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 9 ALA A  55
ALA A  51
ALA A  16
GLY A  58
ALA A  60
 None
 0.96A 5l5zK-2e2nA:
undetectable
5l5zL-2e2nA:
undetectable		 5l5zK-2e2nA:
21.99
5l5zL-2e2nA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		5 / 9 ALA A  55
ALA A  51
ALA A  16
GLY A  58
ALA A  60
 None
 0.96A 5l5zY-2e2nA:
undetectable
5l5zZ-2e2nA:
undetectable		 5l5zY-2e2nA:
21.99
5l5zZ-2e2nA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2e2n HEXOKINASE
(Sulfurisphaera
tokodaii) 		3 / 3 LEU A 105
ILE A 293
TYR A  19
 None
 0.68A 5uunB-2e2nA:
undetectable		 5uunB-2e2nA:
20.83