SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 9 GLU A  69
LEU A  59
ALA A  16
HIS A  62
PRO A  30
 None
 1.43A 1mj2A-2e3dA:
undetectable		 1mj2A-2e3dA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 9 GLU A  69
LEU A  59
ALA A  16
HIS A  62
PRO A  30
 None
 1.44A 1mjoA-2e3dA:
undetectable		 1mjoA-2e3dA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 THR A  26
GLY A 267
ASP A 137
ILE A 139
TYR A  44
 None
 1.16A 1oltA-2e3dA:
undetectable		 1oltA-2e3dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 VAL A  46
ASN A  47
VAL A 102
ILE A 104
 None
 1.07A 1z2bC-2e3dA:
undetectable		 1z2bC-2e3dA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 155
VAL A 169
GLU A 255
 None
 0.87A 3c6gA-2e3dA:
undetectable		 3c6gA-2e3dA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A  45
CYH A  49
ALA A  51
ALA A  52
LEU A 147
 None
 0.94A 3fc6C-2e3dA:
undetectable		 3fc6C-2e3dA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A 115
ILE A  42
ILE A  13
VAL A 133
VAL A 126
 None
 1.12A 3w67A-2e3dA:
undetectable		 3w67A-2e3dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A 220
ALA A 244
ASP A 243
TRP A 225
ILE A 224
 None
 1.40A 3wsjA-2e3dA:
undetectable		 3wsjA-2e3dA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A 134
GLY A 216
ILE A 167
VAL A 254
LEU A 241
 None
 1.23A 4a81A-2e3dA:
undetectable		 4a81A-2e3dA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 8 ALA A 118
PRO A  14
VAL A  60
GLY A 114
GLY A  17
 None
 1.37A 4zjzB-2e3dA:
undetectable		 4zjzB-2e3dA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 ALA A  16
THR A  61
VAL A  60
HIS A  62
 None
 1.00A 5eclA-2e3dA:
undetectable		 5eclA-2e3dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 GLY A  17
GLN A 109
LYS A  65
 None
 0.98A 5imsB-2e3dA:
undetectable		 5imsB-2e3dA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 VAL A  60
HIS A 123
VAL A 126
 None
 0.60A 5jmnC-2e3dA:
undetectable		 5jmnC-2e3dA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 120
GLY A 116
SER A 165
ILE A 245
ASP A 243
 None
 1.24A 6bxmA-2e3dA:
undetectable		 6bxmA-2e3dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 120
GLY A 116
SER A 165
ILE A 245
ASP A 246
 None
 1.36A 6bxnB-2e3dA:
2.1		 6bxnB-2e3dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 120
GLY A 116
VAL A 254
ILE A 245
ASP A 246
 None
 1.48A 6bxnB-2e3dA:
2.1		 6bxnB-2e3dA:
21.61