SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2e3u HYPOTHETICAL PROTEIN
PH1566
(Pyrococcus
horikoshii) 		3 / 3 ARG A  44
ILE A  69
THR A  65
 None
 0.73A 3ia4D-2e3uA:
undetectable		 3ia4D-2e3uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2e3u HYPOTHETICAL PROTEIN
PH1566
(Pyrococcus
horikoshii) 		4 / 6 THR A  63
ILE A  69
ASP A  95
THR A  84
 None
 1.08A 3q70A-2e3uA:
undetectable		 3q70A-2e3uA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2e3u HYPOTHETICAL PROTEIN
PH1566
(Pyrococcus
horikoshii) 		4 / 4 VAL A  90
THR A  79
GLU A  36
GLU A  35
 None
 1.28A 4l78A-2e3uA:
undetectable		 4l78A-2e3uA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2e3u HYPOTHETICAL PROTEIN
PH1566
(Pyrococcus
horikoshii) 		5 / 12 ALA A 170
GLY A 101
GLY A 103
PHE A 104
ILE A  59
 None
 1.01A 4n49A-2e3uA:
undetectable		 4n49A-2e3uA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2e3u HYPOTHETICAL PROTEIN
PH1566
(Pyrococcus
horikoshii) 		4 / 6 GLY A  74
GLU A  75
ASP A  43
ASP A  70
 None
 1.03A 4uckB-2e3uA:
undetectable		 4uckB-2e3uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2e3u HYPOTHETICAL PROTEIN
PH1566
(Pyrococcus
horikoshii) 		4 / 6 ILE A 128
HIS A 194
ILE A 144
VAL A 164
 None
 0.99A 4zj8A-2e3uA:
undetectable		 4zj8A-2e3uA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2e3u HYPOTHETICAL PROTEIN
PH1566
(Pyrococcus
horikoshii) 		4 / 6 PHE A 104
ARG A 108
PRO A 106
ARG A  44
 None
 1.32A 5ih0A-2e3uA:
undetectable		 5ih0A-2e3uA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2e3u HYPOTHETICAL PROTEIN
PH1566
(Pyrococcus
horikoshii) 		3 / 3 TRP A  77
ILE A  69
ASP A  70
 None
 0.87A 6i0y7-2e3uA:
undetectable		 6i0y7-2e3uA:
8.00