SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 8 GLU A 131
ILE A  13
LEU A  15
ALA A  43
 None
 0.74A 1a29A-2e3xA:
undetectable		 1a29A-2e3xA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQU_A_ESTA304_1
(ESTROGEN
SULFOTRANSFERASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		5 / 11 TYR B 123
HIS B  65
SER C 110
TYR C  97
GLU B  98
 None
 1.31A 1aquA-2e3xB:
0.0
1aquB-2e3xB:
0.0		 1aquA-2e3xB:
18.60
1aquB-2e3xB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B  40
TRP B  23
 None
 1.22A 1c4dC-2e3xB:
undetectable
1c4dD-2e3xB:
undetectable		 1c4dC-2e3xB:
10.00
1c4dD-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 6 ASP A 417
VAL A 408
GLY A 406
TYR A 309
 None
 1.29A 1ekjC-2e3xA:
undetectable
1ekjD-2e3xA:
undetectable		 1ekjC-2e3xA:
17.40
1ekjD-2e3xA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		4 / 5 SER C 110
PHE B  99
GLU B  98
GLY B  95
 None
 1.13A 1icrA-2e3xC:
undetectable
1icrB-2e3xC:
undetectable		 1icrA-2e3xC:
22.39
1icrB-2e3xC:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		4 / 5 GLU B  98
GLY B  95
SER C 110
PHE B  99
 None
 1.13A 1icrA-2e3xB:
undetectable
1icrB-2e3xB:
undetectable		 1icrA-2e3xB:
19.72
1icrB-2e3xB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		4 / 6 SER C 110
PHE B  99
GLU B  98
GLY B  95
 None
 1.09A 1icuA-2e3xC:
undetectable
1icuB-2e3xC:
undetectable		 1icuA-2e3xC:
22.39
1icuB-2e3xC:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		4 / 6 GLU B  98
GLY B  95
SER C 110
PHE B  99
 None
 1.10A 1icuA-2e3xB:
undetectable
1icuB-2e3xB:
undetectable		 1icuA-2e3xB:
19.72
1icuB-2e3xB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		4 / 6 SER C 110
PHE B  99
GLU B  98
GLY B  95
 None
 1.10A 1icuC-2e3xC:
undetectable
1icuD-2e3xC:
undetectable		 1icuC-2e3xC:
22.39
1icuD-2e3xC:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		4 / 4 SER C 110
PHE B  99
GLU B  98
GLY B  95
 None
 1.10A 1icvA-2e3xC:
0.0
1icvB-2e3xC:
0.0		 1icvA-2e3xC:
22.39
1icvB-2e3xC:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		4 / 5 SER C 110
PHE B  99
GLU B  98
GLY B  95
 None
 1.12A 1icvC-2e3xC:
undetectable
1icvD-2e3xC:
undetectable		 1icvC-2e3xC:
22.39
1icvD-2e3xC:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		4 / 5 GLU B  98
GLY B  95
SER C 110
PHE B  99
 None
 1.16A 1icvC-2e3xB:
undetectable
1icvD-2e3xB:
undetectable		 1icvC-2e3xB:
19.72
1icvD-2e3xB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 7 VAL A 129
ILE A 128
HIS A  95
LEU A  89
 None
 1.00A 1j96B-2e3xA:
undetectable		 1j96B-2e3xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis;
Daboia
siamensis) 		4 / 6 SER C 110
PHE B  99
GLU B  98
GLY B  95
 None
 1.11A 1kqbA-2e3xC:
undetectable
1kqbB-2e3xC:
undetectable		 1kqbA-2e3xC:
21.39
1kqbB-2e3xC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis;
Daboia
siamensis) 		4 / 5 GLU B  98
GLY B  95
SER C 110
PHE B  99
 None
 1.09A 1kqbA-2e3xB:
undetectable
1kqbB-2e3xB:
undetectable		 1kqbA-2e3xB:
19.27
1kqbB-2e3xB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis;
Daboia
siamensis) 		4 / 6 SER C 110
PHE B  99
GLU B  98
GLY B  95
 None
 1.08A 1kqbC-2e3xC:
undetectable
1kqbD-2e3xC:
undetectable		 1kqbC-2e3xC:
21.39
1kqbD-2e3xC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis;
Daboia
siamensis) 		4 / 6 GLU B  98
GLY B  95
SER C 110
PHE B  99
 None
 1.10A 1kqbC-2e3xB:
undetectable
1kqbD-2e3xB:
undetectable		 1kqbC-2e3xB:
19.27
1kqbD-2e3xB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.29A 1os2A-2e3xA:
10.1		 1os2A-2e3xA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.25A 1os2D-2e3xA:
10.1		 1os2D-2e3xA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 10 THR A 110
HIS A 145
GLU A 146
HIS A 149
HIS A 155
 GM6  A 700 ( 4.6A)
ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.35A 1r55A-2e3xA:
29.6		 1r55A-2e3xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.26A 1uttA-2e3xA:
10.5		 1uttA-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.27A 1utzA-2e3xA:
10.3		 1utzA-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.24A 1utzB-2e3xA:
10.4		 1utzB-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 6 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.25A 1y93A-2e3xA:
10.4		 1y93A-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 11 GLY A 127
THR A 114
GLU A 146
ILE A  52
PHE A  47
 None
None
GM6  A 700 ( 3.4A)
None
None
 1.37A 2dr2A-2e3xA:
undetectable		 2dr2A-2e3xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 155
HIS A 149
HIS A 145
 ZN  A 800 ( 3.1A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.3A)
 0.72A 2einN-2e3xA:
undetectable		 2einN-2e3xA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.23A 2hu6A-2e3xA:
10.4		 2hu6A-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 9 LEU A 111
HIS A 145
GLU A 146
HIS A 149
HIS A 155
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.33A 2jihA-2e3xA:
24.8		 2jihA-2e3xA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 8 LEU A 111
HIS A 145
GLU A 146
HIS A 149
HIS A 155
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.29A 2jihB-2e3xA:
24.7		 2jihB-2e3xA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 8 LEU A 111
HIS A 145
HIS A 149
HIS A 155
LEU A 173
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
GM6  A 700 ( 3.9A)
 0.75A 2jihB-2e3xA:
24.7		 2jihB-2e3xA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 6 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.35A 2ow9A-2e3xA:
10.0		 2ow9A-2e3xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.30A 2ow9B-2e3xA:
9.9		 2ow9B-2e3xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.34A 2ozrC-2e3xA:
9.7		 2ozrC-2e3xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.35A 2ozrD-2e3xA:
9.8		 2ozrD-2e3xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.35A 2ozrE-2e3xA:
9.9		 2ozrE-2e3xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 145
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.36A 2ozrF-2e3xA:
9.8		 2ozrF-2e3xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 12 LEU A 147
MET A 143
ILE A 220
SER A 148
VAL A 168
 None
None
CA  A 802 ( 4.7A)
None
None
 1.33A 2pnjB-2e3xA:
4.4		 2pnjB-2e3xA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 8 ARG A 413
LYS A 357
LYS A 352
ARG A 369
 None
 1.38A 2rk8A-2e3xA:
3.0		 2rk8A-2e3xA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 VAL C 120
TRP C  25
TRP C  67
 None
 1.15A 2xdcA-2e3xC:
undetectable
2xdcB-2e3xC:
undetectable		 2xdcA-2e3xC:
13.51
2xdcB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 VAL C 120
TRP C  67
TRP C  25
 None
 1.45A 2xdcA-2e3xC:
undetectable
2xdcB-2e3xC:
undetectable		 2xdcA-2e3xC:
13.51
2xdcB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 VAL B 126
TRP B  23
TRP B  67
 None
 1.34A 2xdcA-2e3xB:
undetectable
2xdcB-2e3xB:
undetectable		 2xdcA-2e3xB:
10.00
2xdcB-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  25
VAL C 120
TRP C  67
 None
 1.44A 2xdcA-2e3xC:
undetectable
2xdcB-2e3xC:
undetectable		 2xdcA-2e3xC:
13.51
2xdcB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  67
VAL C 120
TRP C  25
 None
 1.16A 2xdcA-2e3xC:
undetectable
2xdcB-2e3xC:
undetectable		 2xdcA-2e3xC:
13.51
2xdcB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B 126
TRP B  23
 None
 1.35A 2xdcA-2e3xB:
undetectable
2xdcB-2e3xB:
undetectable		 2xdcA-2e3xB:
10.00
2xdcB-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 VAL C 120
TRP C  25
TRP C  67
 None
 1.16A 2xdcC-2e3xC:
undetectable
2xdcD-2e3xC:
undetectable		 2xdcC-2e3xC:
13.51
2xdcD-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 VAL B 126
TRP B  23
TRP B  67
 None
 1.33A 2xdcC-2e3xB:
undetectable
2xdcD-2e3xB:
undetectable		 2xdcC-2e3xB:
10.00
2xdcD-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  67
VAL C 120
TRP C  25
 None
 1.12A 2xdcC-2e3xC:
undetectable
2xdcD-2e3xC:
undetectable		 2xdcC-2e3xC:
13.51
2xdcD-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B 126
TRP B  23
 None
 1.12A 2xdcC-2e3xB:
undetectable
2xdcD-2e3xB:
undetectable		 2xdcC-2e3xB:
10.00
2xdcD-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  67
VAL C 120
TRP C  25
 None
 1.14A 2xdcE-2e3xC:
undetectable
2xdcF-2e3xC:
undetectable		 2xdcE-2e3xC:
13.51
2xdcF-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B 126
TRP B  23
 None
 1.14A 2xdcE-2e3xB:
undetectable
2xdcF-2e3xB:
undetectable		 2xdcE-2e3xB:
10.00
2xdcF-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 VAL C 120
TRP C  25
TRP C  67
 None
 1.14A 2y5mA-2e3xC:
undetectable
2y5mB-2e3xC:
undetectable		 2y5mA-2e3xC:
13.51
2y5mB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 VAL C 120
TRP C  67
TRP C  25
 None
 1.44A 2y5mA-2e3xC:
undetectable
2y5mB-2e3xC:
undetectable		 2y5mA-2e3xC:
13.51
2y5mB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 VAL B 126
TRP B  23
TRP B  67
 None
 1.33A 2y5mA-2e3xB:
undetectable
2y5mB-2e3xB:
undetectable		 2y5mA-2e3xB:
10.00
2y5mB-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  67
VAL C 120
TRP C  25
 None
 1.12A 2y5mE-2e3xC:
undetectable
2y5mF-2e3xC:
undetectable		 2y5mE-2e3xC:
13.51
2y5mF-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B 126
TRP B  23
 None
 1.13A 2y5mE-2e3xB:
undetectable
2y5mF-2e3xB:
undetectable		 2y5mE-2e3xB:
10.00
2y5mF-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 VAL C 120
TRP C  25
TRP C  67
 None
 1.14A 2y6nA-2e3xC:
undetectable
2y6nB-2e3xC:
undetectable		 2y6nA-2e3xC:
13.51
2y6nB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 VAL C 120
TRP C  67
TRP C  25
 None
 1.45A 2y6nA-2e3xC:
undetectable
2y6nB-2e3xC:
undetectable		 2y6nA-2e3xC:
13.51
2y6nB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 VAL B 126
TRP B  23
TRP B  67
 None
 1.32A 2y6nA-2e3xB:
undetectable
2y6nB-2e3xB:
undetectable		 2y6nA-2e3xB:
10.00
2y6nB-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  25
VAL C 120
TRP C  67
 None
 1.44A 2y6nA-2e3xC:
undetectable
2y6nB-2e3xC:
undetectable		 2y6nA-2e3xC:
13.51
2y6nB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  67
VAL C 120
TRP C  25
 None
 1.15A 2y6nA-2e3xC:
undetectable
2y6nB-2e3xC:
undetectable		 2y6nA-2e3xC:
13.51
2y6nB-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B 126
TRP B  23
 None
 1.34A 2y6nA-2e3xB:
undetectable
2y6nB-2e3xB:
undetectable		 2y6nA-2e3xB:
10.00
2y6nB-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  67
VAL C 120
TRP C  25
 None
 1.10A 2y6nC-2e3xC:
undetectable
2y6nD-2e3xC:
undetectable		 2y6nC-2e3xC:
13.51
2y6nD-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B 126
TRP B  23
 None
 1.10A 2y6nC-2e3xB:
undetectable
2y6nD-2e3xB:
undetectable		 2y6nC-2e3xB:
10.00
2y6nD-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  67
VAL C 120
TRP C  25
 None
 1.10A 2y6nE-2e3xC:
undetectable
2y6nF-2e3xC:
undetectable		 2y6nE-2e3xC:
13.51
2y6nF-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B 126
TRP B  23
 None
 1.11A 2y6nE-2e3xB:
undetectable
2y6nF-2e3xB:
undetectable		 2y6nE-2e3xB:
10.00
2y6nF-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 MET A 396
GLU A  83
ASN A 354
 None
None
NAG  A 900 ( 3.4A)
 1.10A 3a27A-2e3xA:
undetectable		 3a27A-2e3xA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 12 LEU A 147
MET A 143
ILE A 220
SER A 148
VAL A 168
 None
None
CA  A 802 ( 4.7A)
None
None
 1.29A 3aqiB-2e3xA:
2.8		 3aqiB-2e3xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 12 MET A 119
LEU A 147
MET A 143
ILE A  57
SER A 148
 None
 1.25A 3aqiB-2e3xA:
2.8		 3aqiB-2e3xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 155
HIS A 149
HIS A 145
 ZN  A 800 ( 3.1A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.3A)
 0.72A 3bvdA-2e3xA:
undetectable		 3bvdA-2e3xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 9 LEU A 111
HIS A 145
GLU A 146
HIS A 149
HIS A 155
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.31A 3hy7A-2e3xA:
25.4		 3hy7A-2e3xA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		6 / 9 LEU A 111
HIS A 145
GLU A 146
HIS A 149
HIS A 155
LEU A 173
 GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
GM6  A 700 ( 3.9A)
 0.77A 3hy7B-2e3xA:
25.3		 3hy7B-2e3xA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis;
Daboia
siamensis) 		5 / 12 GLU B  27
GLY B  37
GLY B  69
SER C  82
ARG C  84
 None
 1.14A 3k13B-2e3xB:
undetectable		 3k13B-2e3xB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis;
Daboia
siamensis) 		5 / 12 GLU B  27
GLY B  37
GLY B  69
SER C  82
ARG C  84
 None
 1.15A 3k13C-2e3xB:
undetectable		 3k13C-2e3xB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.30A 3kecA-2e3xA:
10.0		 3kecA-2e3xA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.26A 3likA-2e3xA:
10.4		 3likA-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.25A 3lilA-2e3xA:
10.5		 3lilA-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.27A 3ljgA-2e3xA:
10.6		 3ljgA-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.25A 3lkaA-2e3xA:
10.5		 3lkaA-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 SER A  22
ASP A  66
ASN A  69
 None
None
NAG  A 900 ( 2.0A)
 0.94A 3lsfB-2e3xA:
undetectable
3lsfE-2e3xA:
undetectable		 3lsfB-2e3xA:
18.79
3lsfE-2e3xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 ASP A  66
ASN A  69
SER A  22
 None
NAG  A 900 ( 2.0A)
None
 0.92A 3lsfB-2e3xA:
undetectable
3lsfE-2e3xA:
undetectable		 3lsfB-2e3xA:
18.79
3lsfE-2e3xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 155
HIS A 149
HIS A 145
 ZN  A 800 ( 3.1A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.3A)
 0.78A 3s33A-2e3xA:
undetectable		 3s33A-2e3xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 155
HIS A 149
HIS A 145
 ZN  A 800 ( 3.1A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.3A)
 0.73A 3s38A-2e3xA:
undetectable		 3s38A-2e3xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 155
HIS A 149
HIS A 145
 ZN  A 800 ( 3.1A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.3A)
 0.78A 3s3aA-2e3xA:
undetectable		 3s3aA-2e3xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 155
HIS A 149
HIS A 145
 ZN  A 800 ( 3.1A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.3A)
 0.81A 3s3bA-2e3xA:
undetectable		 3s3bA-2e3xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 155
HIS A 149
HIS A 145
 ZN  A 800 ( 3.1A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.3A)
 0.80A 3s3cA-2e3xA:
undetectable		 3s3cA-2e3xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 HIS A 155
HIS A 149
HIS A 145
 ZN  A 800 ( 3.1A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.3A)
 0.77A 3s3dA-2e3xA:
undetectable		 3s3dA-2e3xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 ILE A  36
THR A  32
SER A  29
PHE A  61
 None
 1.14A 3snfA-2e3xA:
undetectable		 3snfA-2e3xA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 12 LEU A 147
MET A 143
ILE A 220
SER A 148
VAL A 168
 None
None
CA  A 802 ( 4.7A)
None
None
 1.32A 3w1wA-2e3xA:
4.3		 3w1wA-2e3xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 12 MET A 119
LEU A 147
MET A 143
ILE A  57
SER A 148
 None
 1.13A 3w1wA-2e3xA:
4.3		 3w1wA-2e3xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 VAL C 120
TRP C  25
TRP C  67
 None
 1.11A 3zq8A-2e3xC:
undetectable
3zq8B-2e3xC:
undetectable		 3zq8A-2e3xC:
13.51
3zq8B-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 VAL B 126
TRP B  23
TRP B  67
 None
 1.28A 3zq8A-2e3xB:
undetectable
3zq8B-2e3xB:
undetectable		 3zq8A-2e3xB:
10.00
3zq8B-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		3 / 3 TRP C  67
VAL C  42
TRP C  25
 None
 1.02A 3zq8C-2e3xC:
undetectable
3zq8D-2e3xC:
undetectable		 3zq8C-2e3xC:
13.51
3zq8D-2e3xC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2
(Daboia
siamensis) 		3 / 3 TRP B  67
VAL B  40
TRP B  23
 None
 1.15A 3zq8C-2e3xB:
undetectable
3zq8D-2e3xB:
undetectable		 3zq8C-2e3xB:
10.00
3zq8D-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 6 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.43A 4a7bA-2e3xA:
9.7		 4a7bA-2e3xA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 ASP A 279
ARG A 275
ASP A 314
 CA  A 803 ( 2.9A)
None
None
 0.84A 4fp9D-2e3xA:
undetectable		 4fp9D-2e3xA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		3 / 3 PRO A  49
LEU A  50
HIS A 187
 None
 0.47A 4pevA-2e3xA:
3.8		 4pevA-2e3xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		5 / 11 ASP A 391
ALA A  86
GLY A 118
VAL A 126
GLY A  82
 None
 1.07A 4xnxA-2e3xA:
undetectable		 4xnxA-2e3xA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 7 VAL A 129
ILE A 128
HIS A  95
LEU A  89
 None
 1.02A 4xo7A-2e3xA:
undetectable		 4xo7A-2e3xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 7 VAL A 211
ILE A  36
HIS A  95
LEU A  89
 None
 1.19A 4xo7B-2e3xA:
undetectable		 4xo7B-2e3xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.24A 5n5jA-2e3xA:
10.5		 5n5jA-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.25A 5n5kA-2e3xA:
10.6		 5n5kA-2e3xA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 PRO A 399
GLY A 400
THR A 401
LYS A 402
 None
 1.15A 5x23A-2e3xA:
undetectable		 5x23A-2e3xA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 6 PRO A 399
GLY A 400
THR A 401
LYS A 402
 None
 1.09A 5xxiA-2e3xA:
undetectable		 5xxiA-2e3xA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1
(Daboia
siamensis) 		4 / 5 HIS C 104
GLU C  50
LEU C  41
VAL C  42
 None
 1.18A 6bc9A-2e3xC:
undetectable		 6bc9A-2e3xC:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN
(Daboia
siamensis) 		4 / 5 ASN A 320
TYR A 311
GLY A 313
ASP A 398
 None
 1.24A 6gh9A-2e3xA:
undetectable		 6gh9A-2e3xA:
10.38