SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 PHE A 147
ILE A  86
LYS A 152
ALA A 151
 None
 1.18A 1hk2A-2e3zA:
undetectable		 1hk2A-2e3zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		5 / 8 ALA A 208
GLY A 225
ILE A 166
PRO A 171
ILE A 201
 None
 1.49A 1hshD-2e3zA:
undetectable		 1hshD-2e3zA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 5 TYR A 301
LEU A 350
THR A 227
ARG A  77
 None
 1.39A 1i2wA-2e3zA:
undetectable		 1i2wA-2e3zA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 ARG A 256
ILE A 174
PHE A 257
GLU A 170
 None
 1.23A 1nsiA-2e3zA:
undetectable
1nsiB-2e3zA:
undetectable		 1nsiA-2e3zA:
23.58
1nsiB-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 ARG A 256
ILE A 201
PHE A 257
GLU A 170
 None
 1.36A 1nsiA-2e3zA:
undetectable
1nsiB-2e3zA:
undetectable		 1nsiA-2e3zA:
23.58
1nsiB-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 PHE A 257
GLU A 170
ARG A 256
ILE A 174
 None
 1.25A 1nsiA-2e3zA:
undetectable
1nsiB-2e3zA:
undetectable		 1nsiA-2e3zA:
23.58
1nsiB-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 PHE A 257
GLU A 170
ARG A 256
ILE A 201
 None
 1.39A 1nsiA-2e3zA:
undetectable
1nsiB-2e3zA:
undetectable		 1nsiA-2e3zA:
23.58
1nsiB-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 ARG A 256
ILE A 174
PHE A 257
GLU A 170
 None
 1.26A 1nsiC-2e3zA:
undetectable
1nsiD-2e3zA:
undetectable		 1nsiC-2e3zA:
23.58
1nsiD-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 PHE A 257
GLU A 170
ARG A 256
ILE A 174
 None
 1.25A 1nsiC-2e3zA:
undetectable
1nsiD-2e3zA:
undetectable		 1nsiC-2e3zA:
23.58
1nsiD-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 PHE A 257
GLU A 170
ARG A 256
ILE A 201
 None
 1.39A 1nsiC-2e3zA:
undetectable
1nsiD-2e3zA:
undetectable		 1nsiC-2e3zA:
23.58
1nsiD-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 GLY A 367
PHE A 368
ASP A 393
THR A 332
 None
 1.18A 2aouB-2e3zA:
undetectable		 2aouB-2e3zA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 LYS A  27
ASP A  64
ASN A  59
 None
 0.95A 2bm9A-2e3zA:
undetectable		 2bm9A-2e3zA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		5 / 12 LEU A 353
PHE A 296
ILE A 261
ILE A 202
TYR A 357
 None
 1.25A 2efjA-2e3zA:
undetectable		 2efjA-2e3zA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		5 / 12 GLU A 265
ASN A 259
LEU A 247
GLU A 251
ARG A 269
 None
 1.31A 2f10A-2e3zA:
undetectable		 2f10A-2e3zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 LEU A 298
LEU A 228
SER A 175
TYR A 301
 None
 1.25A 2hc4A-2e3zA:
undetectable		 2hc4A-2e3zA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 4 ASP A  26
ASP A  36
ASP A  28
GLY A  23
 None
 1.00A 2igtC-2e3zA:
undetectable		 2igtC-2e3zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 256
ILE A 201
PHE A 257
GLU A 170
 None
 1.31A 2nsiA-2e3zA:
undetectable
2nsiB-2e3zA:
undetectable		 2nsiA-2e3zA:
23.58
2nsiB-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 PHE A 257
GLU A 170
ARG A 256
ILE A 201
 None
 1.31A 2nsiA-2e3zA:
undetectable
2nsiB-2e3zA:
undetectable		 2nsiA-2e3zA:
23.58
2nsiB-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 8 ARG A 277
PRO A 186
VAL A 189
GLY A 180
 None
 1.07A 2qd5B-2e3zA:
undetectable		 2qd5B-2e3zA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 LEU A 138
LEU A 126
ILE A 174
GLU A 193
 None
 1.08A 2qqdA-2e3zA:
undetectable
2qqdE-2e3zA:
undetectable		 2qqdA-2e3zA:
8.62
2qqdE-2e3zA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 5 LEU A 126
ASP A 131
ILE A  34
GLY A 136
 None
 0.89A 3bufA-2e3zA:
undetectable		 3bufA-2e3zA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 256
ILE A 201
PHE A 257
GLU A 170
 None
 1.37A 3e7gA-2e3zA:
undetectable
3e7gB-2e3zA:
0.0		 3e7gA-2e3zA:
22.99
3e7gB-2e3zA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 PHE A 257
GLU A 170
ARG A 256
ILE A 201
 None
 1.41A 3e7gA-2e3zA:
undetectable
3e7gB-2e3zA:
0.0		 3e7gA-2e3zA:
22.99
3e7gB-2e3zA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 256
ILE A 201
PHE A 257
GLU A 170
 None
 1.39A 3e7gC-2e3zA:
undetectable
3e7gD-2e3zA:
undetectable		 3e7gC-2e3zA:
22.99
3e7gD-2e3zA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		5 / 11 TYR A 212
TRP A 165
LEU A 121
TYR A 150
GLU A 156
 None
 1.26A 3m8pA-2e3zA:
0.0
3m8pB-2e3zA:
0.8		 3m8pA-2e3zA:
21.86
3m8pB-2e3zA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		5 / 12 GLY A  90
ILE A  86
ASP A 125
LEU A 126
GLU A 142
 None
 0.94A 3o7wA-2e3zA:
undetectable		 3o7wA-2e3zA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 LYS A 446
ARG A 387
ASP A 375
 None
 1.35A 3o7wA-2e3zA:
undetectable		 3o7wA-2e3zA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 TYR A  58
ASP A  56
ASP A  52
 None
 0.91A 3ou7B-2e3zA:
undetectable		 3ou7B-2e3zA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 5 GLY A 372
ASP A 335
ARG A 430
GLN A 388
 None
 1.43A 3qx3A-2e3zA:
undetectable		 3qx3A-2e3zA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 4 SER A  83
GLY A  51
GLU A 422
 None
 0.54A 3raeA-2e3zA:
undetectable
3raeC-2e3zA:
undetectable		 3raeA-2e3zA:
21.44
3raeC-2e3zA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 5 ILE A  21
TRP A 423
TRP A 124
THR A 167
 None
 1.24A 3topA-2e3zA:
2.3		 3topA-2e3zA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 8 TYR A 179
TYR A 122
LEU A 130
TRP A  82
 None
 1.39A 3uzzB-2e3zA:
10.5		 3uzzB-2e3zA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 GLU A  22
ILE A  21
TYR A  76
VAL A 111
 None
 1.07A 4a97D-2e3zA:
undetectable		 4a97D-2e3zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 GLU A  22
ILE A  21
TYR A  76
VAL A 111
 None
 1.06A 4a97I-2e3zA:
undetectable		 4a97I-2e3zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		5 / 10 ILE A  34
GLY A 178
TYR A 179
GLU A 193
GLY A 182
 None
 1.20A 4bwlC-2e3zA:
10.1		 4bwlC-2e3zA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 8 PHE A 257
GLU A 170
ARG A 256
ILE A 201
 None
 1.31A 4cx7A-2e3zA:
undetectable
4cx7B-2e3zA:
undetectable		 4cx7A-2e3zA:
23.58
4cx7B-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 PHE A 257
GLU A 170
ARG A 256
ILE A 174
 None
 1.19A 4cx7C-2e3zA:
undetectable
4cx7D-2e3zA:
undetectable		 4cx7C-2e3zA:
23.58
4cx7D-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 PHE A 257
GLU A 170
ARG A 256
ILE A 201
 None
 1.33A 4cx7C-2e3zA:
undetectable
4cx7D-2e3zA:
undetectable		 4cx7C-2e3zA:
23.58
4cx7D-2e3zA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 GLU A 193
HIS A 188
PRO A 186
VAL A 197
 None
 1.10A 4hvrA-2e3zA:
undetectable		 4hvrA-2e3zA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 4 SER A  83
GLY A  51
GLU A 422
 None
 0.59A 4juoA-2e3zA:
undetectable
4juoC-2e3zA:
undetectable		 4juoA-2e3zA:
21.44
4juoC-2e3zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 4 SER A 198
GLY A 316
GLU A 244
 None
 0.61A 4juoA-2e3zA:
undetectable
4juoC-2e3zA:
undetectable		 4juoA-2e3zA:
21.44
4juoC-2e3zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 ASP A 125
TRP A 415
SER A  79
 None
 1.01A 4lrhB-2e3zA:
undetectable		 4lrhB-2e3zA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 ASP A 125
TRP A 415
SER A  79
 None
 1.10A 4lrhF-2e3zA:
undetectable		 4lrhF-2e3zA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 PHE A 257
GLU A 170
ARG A 256
ILE A 174
 None
 1.27A 4nosA-2e3zA:
undetectable
4nosB-2e3zA:
undetectable		 4nosA-2e3zA:
22.67
4nosB-2e3zA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 256
ILE A 174
PHE A 257
GLU A 170
 None
 1.30A 4nosC-2e3zA:
undetectable
4nosD-2e3zA:
undetectable		 4nosC-2e3zA:
22.67
4nosD-2e3zA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 PHE A 257
GLU A 170
ARG A 256
ILE A 174
 None
 1.39A 4nosC-2e3zA:
undetectable
4nosD-2e3zA:
undetectable		 4nosC-2e3zA:
22.67
4nosD-2e3zA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 ASN A 169
PHE A 413
TYR A  76
 None
 0.68A 4u15A-2e3zA:
undetectable		 4u15A-2e3zA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 GLU A 285
ILE A 196
ALA A 204
 None
 0.56A 4wnwB-2e3zA:
undetectable		 4wnwB-2e3zA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 GLU A 462
ASP A 408
ARG A 410
GLY A 411
 None
 0.89A 5cdnC-2e3zA:
undetectable
5cdnD-2e3zA:
undetectable		 5cdnC-2e3zA:
22.30
5cdnD-2e3zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 GLU A 462
ASP A 408
ARG A 410
GLY A 411
 None
 0.93A 5cdnT-2e3zA:
undetectable
5cdnU-2e3zA:
undetectable		 5cdnT-2e3zA:
22.30
5cdnU-2e3zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 ASP A 312
LEU A 274
ARG A 277
 None
 0.95A 5e8qA-2e3zA:
undetectable		 5e8qA-2e3zA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 THR A 239
ASP A 240
ALA A 241
 None
 0.10A 5g5gB-2e3zA:
undetectable		 5g5gB-2e3zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 HIS A 459
GLU A 458
TRP A 455
 None
 1.05A 5odqD-2e3zA:
undetectable		 5odqD-2e3zA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		3 / 3 HIS A 459
GLU A 458
TRP A 455
 None
 0.98A 5odrD-2e3zA:
undetectable		 5odrD-2e3zA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 4 ARG A 248
GLN A 307
PHE A 252
LEU A 305
 None
 1.48A 5uhgC-2e3zA:
0.0		 5uhgC-2e3zA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		5 / 12 PHE A 147
VAL A 209
SER A 293
PHE A 295
THR A 120
 None
 1.20A 6cm4A-2e3zA:
undetectable		 6cm4A-2e3zA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 6 TRP A  82
LEU A 203
TYR A 134
GLN A 128
 None
 1.25A 6djzC-2e3zA:
undetectable		 6djzC-2e3zA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2e3z BETA-GLUCOSIDASE
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 423
HIS A 123
HIS A 231
GLU A 365
 None
 1.22A 6mn4D-2e3zA:
undetectable		 6mn4D-2e3zA:
21.24