SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 VAL A 272
VAL A 316
ALA A 288
ILE A 285
ILE A 309
 None
 0.98A 1epbA-2e4uA:
undetectable		 1epbA-2e4uA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 VAL A 272
VAL A 316
ALA A 288
ILE A 285
ILE A 309
 None
 0.94A 1epbB-2e4uA:
undetectable		 1epbB-2e4uA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ALA A 403
GLU A 433
LEU A 404
LEU A  41
LEU A  91
 None
 1.21A 1errB-2e4uA:
undetectable		 1errB-2e4uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 ALA A 286
VAL A 310
TRP A 303
 None
 0.84A 1kqeA-2e4uA:
undetectable
1kqeE-2e4uA:
undetectable		 1kqeA-2e4uA:
9.64
1kqeE-2e4uA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 ALA A 286
VAL A 310
TRP A 303
 None
 0.86A 1kqeB-2e4uA:
undetectable
1kqeD-2e4uA:
undetectable		 1kqeB-2e4uA:
9.64
1kqeD-2e4uA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 TRP A 303
ALA A 286
VAL A 310
 None
 0.86A 1kqeB-2e4uA:
undetectable
1kqeD-2e4uA:
undetectable		 1kqeB-2e4uA:
9.64
1kqeD-2e4uA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 TRP A 303
ALA A 286
VAL A 310
 None
 0.85A 1kqeA-2e4uA:
undetectable
1kqeE-2e4uA:
undetectable		 1kqeA-2e4uA:
9.64
1kqeE-2e4uA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 ALA A 286
VAL A 310
TRP A 303
 None
 0.85A 1micA-2e4uA:
undetectable
1micB-2e4uA:
undetectable		 1micA-2e4uA:
3.85
1micB-2e4uA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 GLN A 165
ILE A 166
TYR A 186
 None
 0.72A 1vifA-2e4uA:
undetectable		 1vifA-2e4uA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A 161
ALA A 158
GLN A 168
SER A 154
LEU A  44
 None
 1.39A 2aa5A-2e4uA:
undetectable		 2aa5A-2e4uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A 161
ALA A 158
GLN A 168
SER A 154
LEU A  44
 None
 1.38A 2aa5B-2e4uA:
undetectable		 2aa5B-2e4uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.90A 2f81B-2e4uA:
undetectable		 2f81B-2e4uA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 LEU A  85
ASP A  77
GLY A  37
ALA A 401
ILE A  79
 None
 1.13A 2idwA-2e4uA:
undetectable		 2idwA-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 9 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.89A 2idwB-2e4uA:
undetectable		 2idwB-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 ARG A 261
ASN A 268
THR A 243
 None
 0.87A 2q63A-2e4uA:
undetectable		 2q63A-2e4uA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 GLY A 223
GLU A 224
PHE A 230
THR A 215
GLU A 231
 None
 1.29A 2vdvF-2e4uA:
undetectable		 2vdvF-2e4uA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A 205
ARG A 237
PHE A 275
ILE A 321
GLY A 484
 None
 1.40A 2vufA-2e4uA:
0.0		 2vufA-2e4uA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 5 SER A 170
PHE A 187
VAL A 157
TYR A 171
 None
 1.29A 2x7hA-2e4uA:
4.6		 2x7hA-2e4uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 5 SER A 170
PHE A 187
VAL A 157
TYR A 171
 None
 1.28A 2x7hB-2e4uA:
2.4		 2x7hB-2e4uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ALA A 105
LEU A 160
ILE A 142
GLY A  42
HIS A  94
 None
 1.06A 2yjaB-2e4uA:
undetectable		 2yjaB-2e4uA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.96A 3cywB-2e4uA:
undetectable		 3cywB-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.90A 3d1xB-2e4uA:
undetectable		 3d1xB-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.93A 3d1zB-2e4uA:
undetectable		 3d1zB-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.92A 3d20B-2e4uA:
undetectable		 3d20B-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 8 ILE A 497
LEU A 492
THR A 296
VAL A 468
 None
 0.72A 3dcjB-2e4uA:
3.1		 3dcjB-2e4uA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 GLU A  49
GLY A  51
THR A  52
 None
 0.46A 3iazA-2e4uA:
1.5		 3iazA-2e4uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.90A 3ndtC-2e4uA:
undetectable		 3ndtC-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.82A 3nduA-2e4uA:
undetectable		 3nduA-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.85A 3nduC-2e4uA:
undetectable		 3nduC-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 10 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.93A 3nu6B-2e4uA:
undetectable		 3nu6B-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 9 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.94A 3nuoB-2e4uA:
undetectable		 3nuoB-2e4uA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.89A 3pwmB-2e4uA:
undetectable		 3pwmB-2e4uA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.90A 3pwrB-2e4uA:
undetectable		 3pwrB-2e4uA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ALA A 105
LEU A 160
ILE A 142
GLY A  42
HIS A  94
 None
 0.98A 3q95A-2e4uA:
undetectable		 3q95A-2e4uA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A 106
ALA A 105
ILE A 142
GLY A  42
HIS A  94
 None
 0.98A 3q95B-2e4uA:
undetectable		 3q95B-2e4uA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 GLU A  62
PHE A 354
GLN A  67
 None
 1.00A 3r55A-2e4uA:
undetectable		 3r55A-2e4uA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 5 SER A 175
PRO A 192
TYR A 196
VAL A 191
 None
 1.42A 3sufC-2e4uA:
undetectable		 3sufC-2e4uA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.91A 3tkgA-2e4uA:
undetectable		 3tkgA-2e4uA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 5 SER A 388
ASP A 334
ASP A 380
ILE A 379
 None
 1.37A 3uj7B-2e4uA:
undetectable		 3uj7B-2e4uA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 SER A 214
VAL A 213
GLN A 197
SER A 300
PHE A 230
 None
 1.39A 4c49D-2e4uA:
undetectable		 4c49D-2e4uA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 10 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.90A 4dqfB-2e4uA:
undetectable		 4dqfB-2e4uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 PRO A  46
TYR A 150
GLY A 148
 None
 0.74A 4g2zA-2e4uA:
undetectable		 4g2zA-2e4uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A 161
VAL A 145
MET A  72
PHE A  45
THR A  98
 None
 1.28A 4iaqA-2e4uA:
undetectable		 4iaqA-2e4uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 ILE A 390
ALA A  71
GLU A  78
TYR A 384
GLU A 387
 None
 1.32A 4j83A-2e4uA:
0.0		 4j83A-2e4uA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 ILE A 390
ALA A  71
GLU A  78
TYR A 384
GLU A 387
 None
 1.15A 4jdsD-2e4uA:
0.0		 4jdsD-2e4uA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ILE A 390
ALA A  71
GLU A  78
TYR A 384
GLU A 387
 None
 1.28A 4jlgA-2e4uA:
undetectable		 4jlgA-2e4uA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 ILE A 390
ALA A  71
GLU A  78
TYR A 384
GLU A 387
 None
 1.29A 4jlgB-2e4uA:
0.0		 4jlgB-2e4uA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 8 LEU A  41
VAL A 397
LEU A 425
LEU A 430
 None
 0.97A 4l1xA-2e4uA:
1.9		 4l1xA-2e4uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 6 MET A 407
MET A 422
LEU A  39
ILE A  76
 None
 1.16A 4okxA-2e4uA:
undetectable		 4okxA-2e4uA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 PHE A 187
PRO A  46
SER A 173
ILE A 155
ASN A 159
 None
None
GLU  A 701 (-4.5A)
None
None
 1.39A 4pl1A-2e4uA:
1.4		 4pl1A-2e4uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 LEU A 106
ALA A 105
ILE A 142
GLY A  42
HIS A  94
 None
 1.00A 4pxmB-2e4uA:
undetectable		 4pxmB-2e4uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 9 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.88A 4rvjB-2e4uA:
undetectable		 4rvjB-2e4uA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 9 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.87A 4rvjD-2e4uA:
undetectable		 4rvjD-2e4uA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ALA A 172
SER A 149
GLU A 324
GLY A 304
GLN A  67
 GLU  A 701 (-3.9A)
GLU  A 701 (-4.0A)
None
None
None
 1.19A 4uilH-2e4uA:
undetectable
4uilL-2e4uA:
undetectable		 4uilH-2e4uA:
15.81
4uilL-2e4uA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 ALA A 105
LEU A 160
ILE A 142
GLY A  42
HIS A  94
 None
 1.02A 5dxbB-2e4uA:
undetectable		 5dxbB-2e4uA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 ARG A 249
THR A 103
ASP A 102
 None
 0.58A 5g5gA-2e4uA:
undetectable
5g5gB-2e4uA:
undetectable		 5g5gA-2e4uA:
15.68
5g5gB-2e4uA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 MET A 276
VAL A 247
ILE A 285
LEU A 274
VAL A 216
 None
 1.19A 5im2A-2e4uA:
undetectable		 5im2A-2e4uA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 6 TYR A 222
THR A 174
ASP A 221
GLY A 220
 GLU  A 701 (-3.8A)
GLU  A 701 (-2.9A)
None
None
 1.17A 5mraA-2e4uA:
undetectable
5mraB-2e4uA:
undetectable		 5mraA-2e4uA:
13.64
5mraB-2e4uA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ILE A  76
GLY A  92
TYR A 398
ALA A  75
MET A  72
 None
 1.20A 5n0rA-2e4uA:
2.7		 5n0rA-2e4uA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ILE A  76
GLY A  92
TYR A 398
ALA A  75
MET A  72
 None
 1.17A 5n0wA-2e4uA:
2.9		 5n0wA-2e4uA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ILE A  76
GLY A  92
TYR A 398
ALA A  75
MET A  72
 None
 1.19A 5n0xB-2e4uA:
2.4		 5n0xB-2e4uA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 10 ALA A 317
VAL A 316
ILE A 260
VAL A 272
ALA A 320
 None
 1.12A 5nukA-2e4uA:
undetectable		 5nukA-2e4uA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 5 ASP A 257
ARG A 290
LEU A 274
MET A 276
 None
 1.44A 5tuiB-2e4uA:
2.8		 5tuiB-2e4uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		3 / 3 PHE A 351
ASP A 353
LEU A  96
 None
 0.76A 5uhcC-2e4uA:
0.9		 5uhcC-2e4uA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 6 ASN A  48
ARG A  31
ILE A  66
GLU A  62
 None
 1.27A 5uigA-2e4uA:
undetectable		 5uigA-2e4uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 8 ARG A  31
SER A 100
THR A  98
GLY A  58
 None
 0.90A 5v0vA-2e4uA:
undetectable		 5v0vA-2e4uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.94A 6dgxA-2e4uA:
undetectable		 6dgxA-2e4uA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A  92
ASP A  77
ILE A 146
ILE A  79
 None
 0.93A 6dh3A-2e4uA:
undetectable		 6dh3A-2e4uA:
9.59