SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 241
GLY A 216
VAL A 246
VAL A  39
ASN A 272
 None
 1.07A 1n2xA-2e54A:
2.3		 1n2xA-2e54A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 9 LEU A 223
PHE A 224
GLY A 241
LEU A  75
LEU A  79
 None
 1.06A 1nr6A-2e54A:
undetectable		 1nr6A-2e54A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 VAL A 339
LEU A 361
ARG A 359
GLY A 327
 None
 0.85A 2xfsA-2e54A:
undetectable		 2xfsA-2e54A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 VAL A 339
LEU A 361
ARG A 359
GLY A 327
 None
 0.84A 2xh9A-2e54A:
undetectable		 2xh9A-2e54A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 PRO A 179
GLU A 195
TYR A 229
 None
 0.68A 2zmbA-2e54A:
undetectable		 2zmbA-2e54A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 9 LEU A 177
LEU A 164
GLU A 192
PHE A 158
GLU A 162
 None
 1.30A 3tmzA-2e54A:
undetectable		 3tmzA-2e54A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 ALA A 353
ILE A 326
GLY A 327
ILE A 328
 None
 0.66A 4eatA-2e54A:
undetectable		 4eatA-2e54A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ALA A 239
GLY A  94
ILE A 248
ASN A  92
GLY A 241
 PLP  A1001 ( 4.9A)
PLP  A1001 (-3.4A)
None
None
None
 1.32A 4obwD-2e54A:
2.5		 4obwD-2e54A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 VAL A  88
ILE A 252
LEU A 286
LEU A 223
 None
 0.97A 4xo7A-2e54A:
undetectable		 4xo7A-2e54A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 ILE A 119
LEU A 207
ALA A 101
ILE A 102
 None
 0.83A 4y03A-2e54A:
undetectable		 4y03A-2e54A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 THR A  95
GLN A 139
GLY A 132
THR A 135
ALA A 136
 PLP  A1001 (-3.7A)
None
None
None
None
 1.37A 5bxnV-2e54A:
undetectable
5bxnW-2e54A:
undetectable		 5bxnV-2e54A:
22.08
5bxnW-2e54A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		6 / 12 GLY A 243
GLY A 245
GLY A  43
LEU A  42
ALA A 275
LEU A 242
 None
None
EDO  A1003 ( 3.8A)
None
None
None
 1.43A 5c0oG-2e54A:
2.1		 5c0oG-2e54A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 266
HIS A 265
VAL A 213
GLY A 270
THR A 268
 None
None
PLP  A1001 (-4.1A)
None
None
 1.01A 5hg0B-2e54A:
undetectable		 5hg0B-2e54A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A 268
HIS A  62
ASN A 272
 None
 0.77A 5n4tA-2e54A:
undetectable		 5n4tA-2e54A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 375
ALA A 353
PHE A 330
LEU A 382
VAL A 316
 None
None
None
None
NA  A1004 (-4.4A)
 1.10A 5tudA-2e54A:
undetectable		 5tudA-2e54A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 375
ALA A 353
PHE A 330
LEU A 382
VAL A 316
 None
None
None
None
NA  A1004 (-4.4A)
 1.10A 5tudD-2e54A:
undetectable		 5tudD-2e54A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 375
VAL A 350
ALA A 353
PHE A 330
VAL A 316
 None
None
None
None
NA  A1004 (-4.4A)
 1.20A 6bqgA-2e54A:
undetectable		 6bqgA-2e54A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 HIS A  62
ASN A 272
LEU A 274
 None
 0.89A 6f7lB-2e54A:
undetectable		 6f7lB-2e54A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A 281
ALA A  52
LYS A  54
 None
 0.48A 6fgcA-2e54A:
undetectable		 6fgcA-2e54A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2e54 ACETYLORNITHINE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A 281
ALA A  52
LYS A  54
 None
 0.47A 6fgdA-2e54A:
undetectable		 6fgdA-2e54A:
21.70