SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 5 MET A 130
ALA A 132
TYR A 190
ILE A 191
 None
SO4  A1301 (-3.1A)
None
None
 0.82A 1upfA-2e55A:
25.8		 1upfA-2e55A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 MET A 130
ALA A 132
TYR A 190
ILE A 191
 None
SO4  A1301 (-3.1A)
None
None
 0.88A 1upfB-2e55A:
25.8		 1upfB-2e55A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 5 MET A 130
ALA A 132
TYR A 190
ILE A 191
 None
SO4  A1301 (-3.1A)
None
None
 1.04A 1upfC-2e55A:
25.7		 1upfC-2e55A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 4 MET A 130
ALA A 132
TYR A 190
ILE A 191
 None
SO4  A1301 (-3.1A)
None
None
 0.91A 1upfD-2e55A:
26.4		 1upfD-2e55A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 5 LEU A 116
PRO A 117
LEU A 119
ILE A 144
 None
 0.77A 2qd4A-2e55A:
3.9		 2qd4A-2e55A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 ILE A  75
PHE A 171
GLY A 134
GLY A 135
 None
None
SO4  A1301 (-3.5A)
SO4  A1301 (-3.6A)
 0.86A 2qx4A-2e55A:
2.4
2qx4B-2e55A:
3.5		 2qx4A-2e55A:
23.55
2qx4B-2e55A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 LEU A  34
PHE A  82
GLY A  85
ILE A  10
VAL A  39
 None
 0.97A 3nk7B-2e55A:
undetectable		 3nk7B-2e55A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 0.41A 3warA-2e55A:
undetectable		 3warA-2e55A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 4 LEU A 116
PRO A 117
LEU A 119
ILE A 144
 None
 0.83A 4f4dB-2e55A:
3.8		 4f4dB-2e55A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 ILE A 198
GLY A 196
ILE A 158
LEU A  31
 None
 0.77A 4o8fB-2e55A:
undetectable		 4o8fB-2e55A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 176
HIS A 156
LEU A 164
GLY A 134
 None
None
None
SO4  A1301 (-3.5A)
 0.96A 4z69A-2e55A:
undetectable		 4z69A-2e55A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 0.47A 5y9mA-2e55A:
undetectable		 5y9mA-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 0.45A 5y9mX-2e55A:
undetectable		 5y9mX-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 0.43A 5yf9B-2e55A:
undetectable		 5yf9B-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 9 LEU A 127
VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 1.22A 5yf9X-2e55A:
undetectable		 5yf9X-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 0.49A 5ywmX-2e55A:
undetectable		 5ywmX-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 158
LEU A 195
GLY A  79
ALA A  78
LEU A 202
 None
 1.20A 5zwrA-2e55A:
undetectable		 5zwrA-2e55A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 LEU A  38
GLY A  85
ALA A  86
VAL A 125
ILE A  70
 None
 1.04A 6dh3B-2e55A:
undetectable		 6dh3B-2e55A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 LEU A  38
GLY A  85
ALA A  86
VAL A 125
ILE A  70
 None
 1.00A 6dh6B-2e55A:
undetectable		 6dh6B-2e55A:
17.91