SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		3 / 3 ASP A 275
PHE A 310
ASN A 302
 None
 0.85A 1sg9B-2e5aA:
2.1		 1sg9B-2e5aA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 9 THR A 257
ILE A 346
GLY A 173
PHE A 253
ILE A 174
 None
 1.39A 2y7wA-2e5aA:
undetectable		 2y7wA-2e5aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 10 LEU A 339
LYS A 271
VAL A 272
ILE A 274
ILE A 306
 None
 1.02A 3kz7A-2e5aA:
undetectable		 3kz7A-2e5aA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		4 / 8 GLY A  78
THR A  79
GLN A  52
GLU A  57
 LAQ  A2001 ( 3.2A)
None
None
None
 0.93A 3rglA-2e5aA:
5.9		 3rglA-2e5aA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		4 / 8 ARG A 109
TYR A 209
GLU A 208
HIS A 213
 None
 1.46A 3zmdA-2e5aA:
undetectable
3zmdB-2e5aA:
undetectable		 3zmdA-2e5aA:
18.80
3zmdB-2e5aA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.17A 4e47A-2e5aA:
undetectable		 4e47A-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.17A 4e47B-2e5aA:
undetectable		 4e47B-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.14A 4e47C-2e5aA:
undetectable		 4e47C-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_D_SAMD800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 10 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.07A 4e47D-2e5aA:
0.0		 4e47D-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.17A 4j83A-2e5aA:
undetectable		 4j83A-2e5aA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.20A 4jdsA-2e5aA:
undetectable		 4jdsA-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.20A 4jdsB-2e5aA:
undetectable		 4jdsB-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.13A 4jdsC-2e5aA:
undetectable		 4jdsC-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.14A 4jdsD-2e5aA:
undetectable		 4jdsD-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.18A 4jlgA-2e5aA:
undetectable		 4jlgA-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.17A 4jlgB-2e5aA:
undetectable		 4jlgB-2e5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		4 / 6 PRO A  54
ILE A 246
THR A  79
ARG A  74
 None
 1.13A 4xe5A-2e5aA:
undetectable		 4xe5A-2e5aA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		4 / 6 GLY A 138
ASP A 127
GLY A  78
ARG A 100
 LAQ  A2001 ( 3.4A)
MG  A3001 ( 3.3A)
LAQ  A2001 ( 3.2A)
ACY  A5001 ( 4.2A)
 1.01A 4z53A-2e5aA:
3.2
4z53B-2e5aA:
2.6		 4z53A-2e5aA:
18.63
4z53B-2e5aA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 ALA A 206
GLU A 208
GLY A   5
ASN A 217
HIS A 218
 None
None
None
None
PO4  A4001 ( 4.9A)
 1.22A 5ayfA-2e5aA:
undetectable		 5ayfA-2e5aA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 11 LEU A 339
LYS A 271
VAL A 272
ILE A 274
ILE A 306
 None
 0.94A 5gpgA-2e5aA:
undetectable		 5gpgA-2e5aA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0B-2e5aA:
undetectable		 6ew0B-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0D-2e5aA:
undetectable		 6ew0D-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0F-2e5aA:
undetectable		 6ew0F-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0G-2e5aA:
undetectable		 6ew0G-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0H-2e5aA:
undetectable		 6ew0H-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0I-2e5aA:
undetectable		 6ew0I-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2e5a LIPOYLTRANSFERASE 1
(Bos
taurus) 		5 / 12 VAL A  80
VAL A  47
HIS A 150
ILE A  87
ASN A  88
 LAQ  A2001 ( 3.6A)
LAQ  A2001 ( 4.8A)
None
None
LAQ  A2001 ( 4.4A)
 1.38A 6mxtA-2e5aA:
undetectable		 6mxtA-2e5aA:
21.69