SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		4 / 7 LEU A 319
GLU A 211
LEU A 207
GLU A 204
 None
 1.04A 1linA-2e5fA:
undetectable		 1linA-2e5fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		3 / 3 LYS A 166
ILE A  15
THR A 140
 None
 0.76A 1rx3A-2e5fA:
1.8		 1rx3A-2e5fA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		4 / 8 LEU A 193
GLU A 218
THR A 237
LEU A 241
 None
 0.65A 1sn5C-2e5fA:
undetectable		 1sn5C-2e5fA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 6 LEU A  37
SER A  46
TYR A  36
LEU A  49
LEU A  35
 None
 1.45A 3f33A-2e5fA:
undetectable		 3f33A-2e5fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 11 MET A  51
LEU A  48
LEU A  45
LEU A 295
GLY A 194
 None
 1.07A 3hm1B-2e5fA:
undetectable		 3hm1B-2e5fA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 12 GLY A  13
ILE A  15
ILE A  14
SER A 138
ILE A 292
 None
 0.81A 4ax8A-2e5fA:
3.6		 4ax8A-2e5fA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 12 GLY A  13
ILE A  15
ILE A  14
SER A 138
ILE A 292
 None
 0.82A 4azvA-2e5fA:
4.1		 4azvA-2e5fA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 9 GLY A 194
ALA A 219
VAL A 201
MET A 242
VAL A 240
 None
 1.41A 4c5lB-2e5fA:
3.5		 4c5lB-2e5fA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 10 GLY A 194
ALA A 219
VAL A 201
MET A 242
VAL A 240
 None
 1.41A 4c5lD-2e5fA:
3.9		 4c5lD-2e5fA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		3 / 3 LYS A 166
ILE A  15
THR A 140
 None
 0.78A 4gh8A-2e5fA:
undetectable		 4gh8A-2e5fA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		4 / 8 LEU A 193
GLU A 218
THR A 237
LEU A 241
 None
 0.92A 4iizB-2e5fA:
undetectable		 4iizB-2e5fA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		4 / 6 LEU A  48
MET A  55
LEU A 147
ILE A 109
 None
 0.83A 4okxA-2e5fA:
undetectable		 4okxA-2e5fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 12 MET A  51
LEU A  48
LEU A  45
LEU A 295
GLY A 194
 None
 1.10A 4pxmA-2e5fA:
undetectable		 4pxmA-2e5fA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 10 LEU A 116
LEU A  35
ALA A  62
ALA A  83
GLY A  38
 None
 1.38A 4rn6A-2e5fA:
undetectable		 4rn6A-2e5fA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		4 / 6 PRO A 293
PHE A 144
THR A 140
ARG A 151
 None
 1.09A 4xe5A-2e5fA:
4.3		 4xe5A-2e5fA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		4 / 4 LEU A 198
TYR A 174
PRO A 293
ILE A 292
 None
 1.41A 5esgA-2e5fA:
undetectable		 5esgA-2e5fA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		4 / 6 PHE A 318
ARG A 317
PRO A 316
ILE A 214
 None
 1.19A 5ih0A-2e5fA:
undetectable		 5ih0A-2e5fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		3 / 3 VAL A  24
LEU A  99
MET A 119
 None
 0.86A 5ikrA-2e5fA:
undetectable		 5ikrA-2e5fA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		5 / 8 VAL A 225
ILE A 191
ALA A 219
HIS A 250
PHE A 223
 None
 1.45A 5l94A-2e5fA:
undetectable		 5l94A-2e5fA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2e5f HYPOTHETICAL PROTEIN
PH0510
(Pyrococcus
horikoshii) 		4 / 6 LEU A 241
VAL A 239
THR A 237
LEU A 253
 None
 0.91A 5tudD-2e5fA:
undetectable		 5tudD-2e5fA:
23.01