SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2e5o ACTIVATING SIGNAL
COINTEGRATOR 1
(Homo
sapiens) 		4 / 6 HIS A  36
THR A  34
LEU A  40
LEU A  10
 None
 0.89A 3bgdA-2e5oA:
undetectable		 3bgdA-2e5oA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2e5o ACTIVATING SIGNAL
COINTEGRATOR 1
(Homo
sapiens) 		5 / 12 SER A 108
LEU A  20
VAL A  84
VAL A  12
CYH A 114
 None
 1.44A 3u9fH-2e5oA:
undetectable
3u9fI-2e5oA:
undetectable		 3u9fH-2e5oA:
17.73
3u9fI-2e5oA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2e5o ACTIVATING SIGNAL
COINTEGRATOR 1
(Homo
sapiens) 		5 / 12 SER A 108
LEU A  20
VAL A  84
VAL A  12
CYH A 114
 None
 1.40A 3u9fJ-2e5oA:
undetectable
3u9fK-2e5oA:
undetectable		 3u9fJ-2e5oA:
17.73
3u9fK-2e5oA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2e5o ACTIVATING SIGNAL
COINTEGRATOR 1
(Homo
sapiens) 		3 / 3 LYS A  47
THR A  45
ILE A  42
 None
 0.93A 4e0fB-2e5oA:
undetectable		 4e0fB-2e5oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2e5o ACTIVATING SIGNAL
COINTEGRATOR 1
(Homo
sapiens) 		4 / 6 ASN A  73
GLU A 119
LYS A 123
TYR A  75
 None
 1.07A 4wcxC-2e5oA:
undetectable		 4wcxC-2e5oA:
16.11