SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 4 GLY A 345
LEU A  68
GLY A 342
ARG A 465
 None
 1.25A 1j7kA-2e5vA:
undetectable		 1j7kA-2e5vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 ASP A 459
GLU A 445
ARG A 447
ILE A 466
ASP A 340
 None
 1.49A 1kijA-2e5vA:
undetectable		 1kijA-2e5vA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 5 GLU A 131
LEU A 125
LEU A 128
LEU A 126
 None
 1.15A 1np1A-2e5vA:
undetectable		 1np1A-2e5vA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 8 ALA A  21
LEU A  18
GLY A  15
GLY A 361
 None
 0.83A 1rukH-2e5vA:
undetectable
1rukL-2e5vA:
undetectable		 1rukH-2e5vA:
20.04
1rukL-2e5vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 8 ALA A 204
ASP A 340
ILE A 202
GLY A 380
ILE A 381
 None
 1.14A 1sh9A-2e5vA:
undetectable		 1sh9A-2e5vA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 7 LYS A  82
GLU A  86
ALA A  46
LEU A  99
 None
 1.13A 1sn0B-2e5vA:
undetectable
1sn0D-2e5vA:
undetectable		 1sn0B-2e5vA:
18.56
1sn0D-2e5vA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 8 SER A 261
GLN A 210
PHE A 211
ASP A 258
 None
 1.24A 1zzuA-2e5vA:
undetectable		 1zzuA-2e5vA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 ILE A 335
ILE A   4
LEU A 203
 None
 0.55A 2prgA-2e5vA:
undetectable		 2prgA-2e5vA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 361
GLY A   6
GLY A   8
SER A  13
ILE A   5
 None
FAD  A1002 (-3.3A)
FAD  A1002 (-3.5A)
None
FAD  A1002 (-4.5A)
 1.15A 2wa2A-2e5vA:
2.1		 2wa2A-2e5vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 10 VAL A  16
ILE A 134
LEU A  27
GLY A   6
ALA A 171
 None
None
None
FAD  A1002 (-3.3A)
None
 1.18A 2xf3A-2e5vA:
undetectable		 2xf3A-2e5vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A   4
GLY A  11
GLY A 361
LEU A 364
ILE A 335
 None
 1.00A 2y7kD-2e5vA:
undetectable		 2y7kD-2e5vA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 PRO A  38
THR A  37
ASN A 188
VAL A  25
LEU A  27
 None
FAD  A1002 (-3.4A)
FAD  A1002 (-3.7A)
None
None
 1.41A 3a51B-2e5vA:
undetectable		 3a51B-2e5vA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 10 ILE A 121
SER A  36
GLY A 118
SER A 353
LEU A 125
 None
FAD  A1002 (-3.7A)
None
FAD  A1002 (-2.6A)
None
 1.38A 3ik6B-2e5vA:
undetectable
3ik6E-2e5vA:
undetectable		 3ik6B-2e5vA:
20.67
3ik6E-2e5vA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 10 SER A 353
LEU A 125
ILE A 121
SER A  36
GLY A 118
 FAD  A1002 (-2.6A)
None
None
FAD  A1002 (-3.7A)
None
 1.40A 3iluB-2e5vA:
undetectable
3iluE-2e5vA:
undetectable		 3iluB-2e5vA:
20.67
3iluE-2e5vA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A 121
SER A  36
GLY A 118
SER A 353
LEU A 125
 None
FAD  A1002 (-3.7A)
None
FAD  A1002 (-2.6A)
None
 1.37A 3iluB-2e5vA:
undetectable
3iluE-2e5vA:
undetectable		 3iluB-2e5vA:
20.67
3iluE-2e5vA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 196
LEU A 141
LEU A 168
VAL A 151
THR A 201
 None
FAD  A1002 (-4.6A)
None
None
None
 1.07A 3jw5A-2e5vA:
undetectable		 3jw5A-2e5vA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 10 ALA A 196
LEU A 141
LEU A 168
VAL A 151
THR A 201
 None
FAD  A1002 (-4.6A)
None
None
None
 1.09A 3jw5B-2e5vA:
undetectable		 3jw5B-2e5vA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 6 PHE A 244
ILE A 264
ALA A 263
ALA A 255
 None
 0.96A 3mdrB-2e5vA:
undetectable		 3mdrB-2e5vA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 8 SER A 261
GLN A 210
PHE A 211
ASP A 258
 None
 1.28A 3n62B-2e5vA:
undetectable		 3n62B-2e5vA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 ASP A 191
GLU A 157
SER A 176
 FAD  A1002 (-2.9A)
None
None
 0.81A 3p2kA-2e5vA:
2.8		 3p2kA-2e5vA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 HIS A 112
ARG A 100
GLU A 102
 None
None
CL  A2001 ( 4.6A)
 0.55A 3qf1A-2e5vA:
undetectable		 3qf1A-2e5vA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 8 GLY A  11
GLY A   8
GLY A 357
ILE A 121
LEU A 354
 None
FAD  A1002 (-3.5A)
None
None
FAD  A1002 (-3.7A)
 1.33A 3v1nA-2e5vA:
undetectable		 3v1nA-2e5vA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 7 THR A  73
HIS A 344
ASN A 352
LEU A 355
 None
 1.15A 4awuA-2e5vA:
undetectable		 4awuA-2e5vA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A   5
GLY A  34
SER A   7
GLY A  11
LEU A  12
 FAD  A1002 (-4.5A)
FAD  A1002 ( 4.0A)
FAD  A1002 (-3.0A)
None
None
 1.04A 4e1gA-2e5vA:
undetectable		 4e1gA-2e5vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A   5
GLY A  34
SER A   7
GLY A  11
LEU A  12
 FAD  A1002 (-4.5A)
FAD  A1002 ( 4.0A)
FAD  A1002 (-3.0A)
None
None
 1.06A 4e1gB-2e5vA:
undetectable		 4e1gB-2e5vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 TYR A 294
HIS A 298
ARG A 297
 None
 1.18A 4e7bC-2e5vA:
undetectable		 4e7bC-2e5vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A 306
ALA A 296
LEU A 295
VAL A 291
LEU A 278
 None
 1.11A 4g1bB-2e5vA:
2.9		 4g1bB-2e5vA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A  47
ALA A  45
VAL A  44
 None
 0.49A 4o2bA-2e5vA:
2.2		 4o2bA-2e5vA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A  47
ALA A  45
VAL A  44
 None
 0.50A 4o2bC-2e5vA:
2.1		 4o2bC-2e5vA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 4 THR A 184
GLY A 190
ASP A 191
SER A 176
 FAD  A1002 ( 4.4A)
None
FAD  A1002 (-2.9A)
None
 1.28A 4rfqA-2e5vA:
2.2		 4rfqA-2e5vA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A  47
ASP A 316
ASP A  60
 None
 0.80A 4uckA-2e5vA:
undetectable		 4uckA-2e5vA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 352
SER A  47
ALA A  45
VAL A  44
 None
 0.63A 4x1kC-2e5vA:
undetectable		 4x1kC-2e5vA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A  47
ALA A  45
VAL A  44
 None
 0.51A 4x20C-2e5vA:
undetectable		 4x20C-2e5vA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 170
LEU A 332
ILE A 319
GLU A 207
LEU A 141
 None
None
None
None
FAD  A1002 (-4.6A)
 0.96A 4y0sA-2e5vA:
undetectable		 4y0sA-2e5vA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 121
LEU A 355
VAL A  84
GLY A  92
PHE A  95
 None
 0.91A 5byjA-2e5vA:
undetectable		 5byjA-2e5vA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 6 SER A  29
GLU A 138
GLY A 361
GLY A  15
 FAD  A1002 (-2.9A)
None
None
None
 0.91A 5cdnR-2e5vA:
undetectable
5cdnS-2e5vA:
undetectable		 5cdnR-2e5vA:
22.84
5cdnS-2e5vA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 327
GLY A 190
ASP A 191
GLY A 173
 None
None
FAD  A1002 (-2.9A)
FAD  A1002 ( 3.8A)
 0.94A 5cdnT-2e5vA:
undetectable
5cdnU-2e5vA:
undetectable		 5cdnT-2e5vA:
22.84
5cdnU-2e5vA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 327
GLY A 190
ASP A 191
GLY A 173
 None
None
FAD  A1002 (-2.9A)
FAD  A1002 ( 3.8A)
 0.70A 5cdpA-2e5vA:
undetectable
5cdpB-2e5vA:
undetectable		 5cdpA-2e5vA:
22.56
5cdpB-2e5vA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 6 ARG A 140
ASP A 139
ARG A 159
GLY A 160
 None
 1.00A 5cdqA-2e5vA:
undetectable
5cdqC-2e5vA:
undetectable
5cdqD-2e5vA:
undetectable		 5cdqA-2e5vA:
22.84
5cdqC-2e5vA:
22.84
5cdqD-2e5vA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 336
ILE A   9
LEU A 358
GLY A  11
GLY A 192
 FAD  A1002 (-3.1A)
FAD  A1002 (-4.8A)
None
None
FAD  A1002 ( 4.6A)
 1.08A 5d4uB-2e5vA:
2.6		 5d4uB-2e5vA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 374
LEU A 203
ILE A 189
GLY A 190
THR A 172
 None
None
None
None
FAD  A1002 (-4.1A)
 1.18A 5fsaB-2e5vA:
undetectable		 5fsaB-2e5vA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 6 ASP A 340
GLY A 342
ASP A  70
ASP A 205
 None
 1.10A 5hp1A-2e5vA:
undetectable		 5hp1A-2e5vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 423
TYR A 422
TYR A 434
 None
 0.77A 5lakA-2e5vA:
undetectable
5lakI-2e5vA:
undetectable		 5lakA-2e5vA:
19.33
5lakI-2e5vA:
1.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 423
TYR A 422
TYR A 434
 None
 0.72A 5lakC-2e5vA:
undetectable
5lakJ-2e5vA:
undetectable		 5lakC-2e5vA:
19.33
5lakJ-2e5vA:
1.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 352
SER A  47
ALA A  45
VAL A  44
 None
 0.70A 5nm5A-2e5vA:
2.7		 5nm5A-2e5vA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 9 LEU A 170
ILE A   5
GLY A   6
GLY A  11
LEU A 332
 None
FAD  A1002 (-4.5A)
FAD  A1002 (-3.3A)
None
None
 0.99A 5o96A-2e5vA:
undetectable
5o96B-2e5vA:
undetectable		 5o96A-2e5vA:
21.40
5o96B-2e5vA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A  25
LEU A  18
ASP A 369
VAL A 169
ILE A   4
 None
 1.06A 5om2A-2e5vA:
undetectable
5om2B-2e5vA:
undetectable		 5om2A-2e5vA:
9.52
5om2B-2e5vA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 7 LEU A 203
ALA A 194
ILE A 387
LEU A 470
 None
 0.96A 5te8C-2e5vA:
undetectable		 5te8C-2e5vA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 6 LYS A 444
ARG A 410
GLU A 441
ALA A 439
 None
 1.23A 6an0A-2e5vA:
1.8		 6an0A-2e5vA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 PHE A 284
ASP A 283
LYS A 287
 None
 0.88A 6awtD-2e5vA:
undetectable		 6awtD-2e5vA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		3 / 3 HIS A 212
HIS A 313
ARG A 348
 None
FAD  A1002 (-4.2A)
CL  A2001 ( 3.2A)
 0.34A 6b58A-2e5vA:
43.9		 6b58A-2e5vA:
32.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2e5v L-ASPARTATE OXIDASE
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A  62
THR A  61
THR A 106
SER A  53
 None
 1.13A 6c06C-2e5vA:
undetectable		 6c06C-2e5vA:
undetectable