SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DTT_C_H4BC1002_1 (HYPOTHETICAL PROTEIN PH0634)	2e63	KIAA1787 PROTEIN (Homo sapiens)	4 / 6	ASP A 142 THR A 129 GLU A 127 GLU A 133	None	1.23A	2dttB-2e63A: undetectable 2dttC-2e63A: undetectable	2dttB-2e63A: 22.09 2dttC-2e63A: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QEO_B_LLTB261_1 (DEOXYCYTIDINE KINASE)	2e63	KIAA1787 PROTEIN (Homo sapiens)	4 / 7	VAL A 17 LEU A 160 PHE A 81 LEU A 88	None	0.93A	3qeoB-2e63A: undetectable	3qeoB-2e63A: 24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J14_A_X2NA602_1 (CHOLESTEROL 24-HYDROXYLASE)	2e63	KIAA1787 PROTEIN (Homo sapiens)	5 / 10	ALA A 147 LEU A 134 VAL A 126 ALA A 156 ALA A 85	None	1.01A	4j14A-2e63A: undetectable	4j14A-2e63A: 17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZAU_A_YY3A1101_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2e63	KIAA1787 PROTEIN (Homo sapiens)	5 / 8	LEU A 108 VAL A 100 ALA A 147 GLY A 144 CYH A 143	None	1.25A	4zauA-2e63A: undetectable	4zauA-2e63A: 18.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2DTT_C_H4BC1002_1","HYPOTHETICAL PROTEIN PH0634;HYPOTHETICAL PROTEIN PH0634","2e63","KIAA1787 PROTEIN","Homo sapiens",4,"ASP A 142;THR A 129;GLU A 127;GLU A 133","None","1.23A","2dttB-2e63A:undetectable;2dttC-2e63A:undetectable","2dttB-2e63A:22.09;2dttC-2e63A:22.09"],["3QEO_B_LLTB261_1","DEOXYCYTIDINE KINASE","2e63","KIAA1787 PROTEIN","Homo sapiens",4,"VAL A  17;LEU A 160;PHE A  81;LEU A  88","None","0.93A","3qeoB-2e63A:undetectable","3qeoB-2e63A:24.15"],["4J14_A_X2NA602_1","CHOLESTEROL 24-HYDROXYLASE","2e63","KIAA1787 PROTEIN","Homo sapiens",5,"ALA A 147;LEU A 134;VAL A 126;ALA A 156;ALA A  85","None","1.01A","4j14A-2e63A:undetectable","4j14A-2e63A:17.99"],["4ZAU_A_YY3A1101_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2e63","KIAA1787 PROTEIN","Homo sapiens",5,"LEU A 108;VAL A 100;ALA A 147;GLY A 144;CYH A 143","None","1.25A","4zauA-2e63A:undetectable","4zauA-2e63A:18.45"]]