SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 9 PRO A  74
THR A  76
GLY A  78
LEU A  63
ARG A  82
 None
 1.37A 1urmA-2e67A:
undetectable		 1urmA-2e67A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 8 TYR A  32
LEU A  22
HIS A  18
HIS A 123
 None
 0.94A 2bnnA-2e67A:
undetectable
2bnnB-2e67A:
undetectable		 2bnnA-2e67A:
22.01
2bnnB-2e67A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 8 TYR A 140
LEU A  61
HIS A 123
HIS A  18
 None
 0.91A 2bnnA-2e67A:
undetectable
2bnnB-2e67A:
undetectable		 2bnnA-2e67A:
22.01
2bnnB-2e67A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		3 / 3 LEU A 239
TYR A 199
GLY A 197
 None
 0.54A 2ocuA-2e67A:
undetectable		 2ocuA-2e67A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 8 ASP A  20
ASP A 125
LEU A 152
HIS A  18
 MG  A 301 (-4.3A)
None
None
None
 0.95A 2q0iA-2e67A:
undetectable		 2q0iA-2e67A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 8 ASP A  21
LEU A  24
HIS A 127
SER A  65
 MG  A 301 (-2.6A)
None
MG  A 301 (-3.0A)
None
 0.90A 2q0iA-2e67A:
undetectable		 2q0iA-2e67A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 7 VAL A  44
ALA A 115
PRO A  74
THR A  76
 None
 0.99A 2q6oA-2e67A:
undetectable		 2q6oA-2e67A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		3 / 3 SER A 216
ARG A 232
GLN A  28
 None
 0.83A 2xnrA-2e67A:
undetectable		 2xnrA-2e67A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 12 HIS A 215
ASP A  21
ASP A  20
HIS A  60
GLU A  66
 None
MG  A 301 (-2.6A)
MG  A 301 (-4.3A)
MG  A 301 (-3.3A)
None
 1.38A 3lmyB-2e67A:
5.9		 3lmyB-2e67A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 12 TYR A 210
HIS A 252
GLY A  11
LEU A   7
GLY A   8
 None
 1.16A 3vywC-2e67A:
undetectable		 3vywC-2e67A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 7 TYR A 211
HIS A 215
ASP A 125
HIS A  18
 None
 1.43A 3zodA-2e67A:
undetectable		 3zodA-2e67A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 12 GLU A 107
GLY A  78
ARG A 100
VAL A  59
VAL A  44
 None
 1.41A 4ffwA-2e67A:
undetectable		 4ffwA-2e67A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 8 PRO A  70
MET A  72
TRP A  67
TYR A 188
 None
 1.47A 4v2zB-2e67A:
undetectable		 4v2zB-2e67A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 8 PRO A  70
MET A  72
TRP A  67
TYR A 188
 None
 1.47A 4v30B-2e67A:
0.0		 4v30B-2e67A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		3 / 3 VAL A  59
ALA A 114
PHE A 119
 None
 0.86A 4w5nA-2e67A:
undetectable		 4w5nA-2e67A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 12 HIS A  60
ASP A  20
ASP A 186
HIS A  18
GLY A 129
 MG  A 301 (-3.3A)
MG  A 301 (-4.3A)
None
None
None
 1.44A 5hm8E-2e67A:
undetectable		 5hm8E-2e67A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 6 ASP A  20
ASP A  21
HIS A  60
HIS A 127
HIS A 215
 MG  A 301 (-4.3A)
MG  A 301 (-2.6A)
MG  A 301 (-3.3A)
MG  A 301 (-3.0A)
None
 0.77A 5ncdA-2e67A:
9.9
5ncdD-2e67A:
9.7		 5ncdA-2e67A:
19.65
5ncdD-2e67A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 6 ASP A  20
ASP A  21
HIS A  60
HIS A 127
HIS A 215
 MG  A 301 (-4.3A)
MG  A 301 (-2.6A)
MG  A 301 (-3.3A)
MG  A 301 (-3.0A)
None
 0.67A 5ncdB-2e67A:
9.8
5ncdC-2e67A:
10.0		 5ncdB-2e67A:
19.65
5ncdC-2e67A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 4 ASP A  20
HIS A  60
HIS A 127
HIS A 215
 MG  A 301 (-4.3A)
MG  A 301 (-3.3A)
MG  A 301 (-3.0A)
None
 0.83A 5ncdD-2e67A:
9.5		 5ncdD-2e67A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 8 ASP A  20
ASP A  21
HIS A  60
HIS A 127
HIS A 215
 MG  A 301 (-4.3A)
MG  A 301 (-2.6A)
MG  A 301 (-3.3A)
MG  A 301 (-3.0A)
None
 0.77A 5nekB-2e67A:
9.7		 5nekB-2e67A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 8 ASP A  20
ASP A  21
HIS A  60
HIS A 127
HIS A 215
 MG  A 301 (-4.3A)
MG  A 301 (-2.6A)
MG  A 301 (-3.3A)
MG  A 301 (-3.0A)
None
 0.79A 5nekD-2e67A:
9.7		 5nekD-2e67A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 6 ASP A  20
ASP A  21
HIS A  60
HIS A 127
HIS A 215
 MG  A 301 (-4.3A)
MG  A 301 (-2.6A)
MG  A 301 (-3.3A)
MG  A 301 (-3.0A)
None
 0.79A 5nelA-2e67A:
9.8
5nelD-2e67A:
9.7		 5nelA-2e67A:
19.65
5nelD-2e67A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 6 ASP A  20
HIS A  60
HIS A 127
HIS A 215
 MG  A 301 (-4.3A)
MG  A 301 (-3.3A)
MG  A 301 (-3.0A)
None
 0.79A 5nelB-2e67A:
9.7
5nelC-2e67A:
9.8		 5nelB-2e67A:
19.65
5nelC-2e67A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		3 / 3 HIS A 215
ASP A  21
HIS A  60
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.3A)
 0.77A 5oexB-2e67A:
undetectable		 5oexB-2e67A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		3 / 3 HIS A 215
ASP A  21
HIS A  60
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.3A)
 0.75A 5oexC-2e67A:
undetectable		 5oexC-2e67A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		3 / 3 HIS A 215
ASP A  21
HIS A  60
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.3A)
 0.76A 5oexD-2e67A:
undetectable		 5oexD-2e67A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 12 ASP A  21
HIS A 215
ARG A 232
PRO A 227
HIS A  60
 MG  A 301 (-2.6A)
None
None
None
MG  A 301 (-3.3A)
 1.41A 5uhgC-2e67A:
0.0		 5uhgC-2e67A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		5 / 12 GLY A  46
GLY A  23
GLY A  51
HIS A  60
PHE A  88
 None
None
None
MG  A 301 (-3.3A)
None
 0.97A 5vimA-2e67A:
undetectable		 5vimA-2e67A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 7 ARG A 148
GLU A 145
PRO A 151
PRO A 178
 None
 1.45A 6a4iB-2e67A:
undetectable		 6a4iB-2e67A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2e67 HYPOTHETICAL PROTEIN
TTHB029
(Thermus
thermophilus) 		4 / 6 THR A  64
LEU A  63
MET A  43
LEU A 132
 None
 1.08A 6mvxA-2e67A:
undetectable
6mvxB-2e67A:
undetectable
6mvxC-2e67A:
undetectable		 6mvxA-2e67A:
20.34
6mvxB-2e67A:
20.34
6mvxC-2e67A:
20.34