SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		5 / 12 LEU A 152
LEU A 155
SER A 123
ALA A 124
SER A 223
 None
 1.08A 1eqbA-2e6eA:
undetectable		 1eqbA-2e6eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		5 / 12 LEU A 152
LEU A 155
SER A 123
ALA A 124
SER A 223
 None
 1.08A 1eqbB-2e6eA:
undetectable		 1eqbB-2e6eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		5 / 12 LEU A 152
LEU A 155
SER A 123
ALA A 124
SER A 223
 None
 1.08A 1eqbC-2e6eA:
2.5		 1eqbC-2e6eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		5 / 12 LEU A 152
LEU A 155
SER A 123
ALA A 124
SER A 223
 None
 1.08A 1eqbD-2e6eA:
undetectable		 1eqbD-2e6eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		5 / 12 LEU A  90
LEU A  92
PHE A 127
THR A 148
ALA A  22
 None
 1.24A 1n5xA-2e6eA:
undetectable		 1n5xA-2e6eA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		5 / 12 LEU A  90
LEU A  92
PHE A 127
THR A 148
ALA A  22
 None
 1.23A 1n5xB-2e6eA:
undetectable		 1n5xB-2e6eA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 8 LEU A 119
GLY A 117
LEU A 229
PRO A 158
 None
 0.82A 1ya4A-2e6eA:
undetectable		 1ya4A-2e6eA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 7 LEU A 119
GLY A 117
LEU A 229
PRO A 158
 None
 0.86A 1ya4B-2e6eA:
1.3		 1ya4B-2e6eA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		6 / 12 ILE A   3
LEU A  92
GLY A  94
ARG A 142
ALA A  22
ALA A  23
 None
 1.44A 2oc8A-2e6eA:
undetectable		 2oc8A-2e6eA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 7 ASN A   7
ALA A  33
PRO A  34
ALA A 113
 None
 1.13A 3twpC-2e6eA:
undetectable		 3twpC-2e6eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 5 ASN A   7
ALA A  33
PRO A  34
ALA A 113
 None
 1.15A 3twpD-2e6eA:
undetectable		 3twpD-2e6eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 8 ASN A   7
ASP A   9
VAL A  31
LEU A  19
 None
 1.03A 4f8hA-2e6eA:
undetectable
4f8hB-2e6eA:
undetectable		 4f8hA-2e6eA:
22.29
4f8hB-2e6eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 8 ASN A   7
ASP A   9
VAL A  31
LEU A  19
 None
 1.04A 4f8hC-2e6eA:
undetectable
4f8hD-2e6eA:
undetectable		 4f8hC-2e6eA:
22.29
4f8hD-2e6eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 8 ASN A   7
ASP A   9
VAL A  31
LEU A  19
 None
 1.05A 4f8hD-2e6eA:
undetectable
4f8hE-2e6eA:
undetectable		 4f8hD-2e6eA:
22.29
4f8hE-2e6eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 8 VAL A  31
LEU A  19
ASN A   7
ASP A   9
 None
 1.07A 4f8hA-2e6eA:
undetectable
4f8hE-2e6eA:
undetectable		 4f8hA-2e6eA:
22.29
4f8hE-2e6eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		4 / 5 ARG A   2
GLY A  27
GLU A  28
ARG A 157
 None
 1.12A 5cdqA-2e6eA:
undetectable
5cdqB-2e6eA:
2.0
5cdqC-2e6eA:
undetectable		 5cdqA-2e6eA:
21.19
5cdqB-2e6eA:
21.81
5cdqC-2e6eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 2e6e 5'-NUCLEOTIDASE SURE
(Thermus
thermophilus) 		5 / 12 VAL A 217
ASN A 164
ARG A 214
THR A   6
GLU A 104
 None
 1.14A 5v1tA-2e6eA:
undetectable		 5v1tA-2e6eA:
18.30