SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 10 HIS A 554
ALA A 354
THR A 514
ILE A 349
GLY A 550
 None
 1.14A 1c9sN-2e6kA:
undetectable
1c9sO-2e6kA:
undetectable		 1c9sN-2e6kA:
6.45
1c9sO-2e6kA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 11 HIS A 554
ALA A 354
THR A 514
ILE A 349
GLY A 550
 None
 1.14A 1c9sP-2e6kA:
undetectable
1c9sQ-2e6kA:
undetectable		 1c9sP-2e6kA:
6.45
1c9sQ-2e6kA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 8 GLU A 326
ARG A 329
ARG A 330
GLU A 140
 None
 0.93A 1cmaA-2e6kA:
undetectable
1cmaB-2e6kA:
undetectable		 1cmaA-2e6kA:
11.08
1cmaB-2e6kA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 7 LEU A 511
VAL A 453
TYR A 425
LEU A 362
 None
 0.84A 1cqpA-2e6kA:
undetectable
1cqpB-2e6kA:
undetectable		 1cqpA-2e6kA:
13.08
1cqpB-2e6kA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 ALA A 374
GLY A 410
GLY A 426
GLY A 427
LEU A 416
 None
 1.00A 1eizA-2e6kA:
2.4		 1eizA-2e6kA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 ALA A 374
GLY A 410
GLY A 426
GLY A 427
LEU A 416
 None
 0.99A 1ej0A-2e6kA:
2.5		 1ej0A-2e6kA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 8 THR A 110
PRO A 111
GLY A 112
LEU A  91
 None
 0.46A 1h4oG-2e6kA:
undetectable		 1h4oG-2e6kA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 8 LEU A 132
PRO A 395
TYR A 422
GLU A 134
 None
 1.17A 1jtvA-2e6kA:
2.1		 1jtvA-2e6kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 GLU A 603
ILE A 486
ALA A 489
ARG A 478
GLU A 579
 None
 1.35A 1ki7A-2e6kA:
undetectable		 1ki7A-2e6kA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 GLU A 603
ILE A 486
ALA A 489
ARG A 478
GLU A 579
 None
 1.36A 1ki7B-2e6kA:
undetectable		 1ki7B-2e6kA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 4 LYS A 136
LEU A 132
LEU A 179
SER A 180
 None
 1.40A 1tz8D-2e6kA:
0.0		 1tz8D-2e6kA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 LEU A 400
LEU A 370
GLY A 415
ASN A 417
ALA A 439
 None
 1.28A 2bm9B-2e6kA:
2.9		 2bm9B-2e6kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 LEU A 400
LEU A 370
GLY A 415
ASN A 417
ALA A 439
 None
 1.16A 2bm9C-2e6kA:
undetectable		 2bm9C-2e6kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 HIS A 419
GLY A 129
ASN A 414
LEU A 413
LEU A 130
 None
 1.00A 2f8lA-2e6kA:
2.8		 2f8lA-2e6kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 HIS A 419
GLY A 129
ASN A 414
LEU A 413
PHE A 390
 None
 0.98A 2f8lA-2e6kA:
2.8		 2f8lA-2e6kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 9 LEU A 597
VAL A 599
VAL A 535
ASP A 538
VAL A 573
 None
 1.28A 2l8mA-2e6kA:
undetectable		 2l8mA-2e6kA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 6 PRO A 289
HIS A 295
ASP A 297
TYR A 293
 None
 1.36A 2lh8A-2e6kA:
undetectable		 2lh8A-2e6kA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 7 GLY A  71
MET A  33
GLY A 112
PHE A  45
 None
 0.94A 2qwxA-2e6kA:
undetectable
2qwxB-2e6kA:
3.1		 2qwxA-2e6kA:
17.60
2qwxB-2e6kA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 7 THR A 110
PRO A 111
GLY A 112
LEU A  91
 None
 0.44A 2vl2B-2e6kA:
undetectable		 2vl2B-2e6kA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 GLY A 605
HIS A 473
LEU A 430
ALA A 606
SER A 577
 None
 1.37A 2vmyB-2e6kA:
undetectable		 2vmyB-2e6kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 GLY A 415
LEU A 182
VAL A 184
SER A 167
GLY A 168
 None
 1.07A 2vmyA-2e6kA:
undetectable		 2vmyA-2e6kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 7 LEU A 137
PHE A 141
LEU A 331
PRO A 367
 None
 0.96A 2vq5B-2e6kA:
undetectable		 2vq5B-2e6kA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 7 LEU A 156
LEU A  66
PHE A  64
LEU A  40
 None
 0.95A 2vq5B-2e6kA:
undetectable		 2vq5B-2e6kA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 4 TYR A  84
LEU A  86
LEU A  79
HIS A  51
 None
 1.12A 2x7hB-2e6kA:
2.6		 2x7hB-2e6kA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 10 TYR A 399
TRP A 177
ASN A 380
VAL A 453
LEU A 413
 None
 1.18A 3casA-2e6kA:
undetectable		 3casA-2e6kA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		6 / 12 GLY A 121
GLY A 123
ALA A 127
ALA A 157
ALA A 408
VAL A 166
 None
 1.29A 3jb2A-2e6kA:
undetectable		 3jb2A-2e6kA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 ARG A 208
GLY A 129
ALA A 171
GLY A 168
ILE A 412
 None
 0.86A 3ku1A-2e6kA:
3.2		 3ku1A-2e6kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 ARG A 208
GLY A 129
ALA A 171
GLY A 168
ILE A 412
 None
 0.86A 3ku1G-2e6kA:
undetectable		 3ku1G-2e6kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		3 / 3 HIS A 295
ARG A  46
GLU A   8
 None
 1.15A 3qf1A-2e6kA:
0.0		 3qf1A-2e6kA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 6 SER A 433
VAL A 485
THR A 455
THR A 514
 None
 1.07A 3tneA-2e6kA:
undetectable		 3tneA-2e6kA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		6 / 12 ILE A 124
ASP A 161
GLY A 121
GLY A 123
LEU A 182
GLY A  69
 None
 1.23A 4e3aB-2e6kA:
undetectable		 4e3aB-2e6kA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 8 GLY A 528
GLY A 533
TYR A 613
LEU A 575
VAL A 573
 None
 1.31A 4fgzA-2e6kA:
undetectable		 4fgzA-2e6kA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		3 / 3 PRO A 105
TYR A  76
GLY A  71
 None
 0.70A 4g2zA-2e6kA:
undetectable		 4g2zA-2e6kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 11 ASN A 381
VAL A 453
GLY A 427
THR A 455
LEU A 513
 None
 1.47A 4or0A-2e6kA:
1.7		 4or0A-2e6kA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		3 / 3 LEU A 366
LEU A 137
ASN A 417
 None
 0.44A 4otwA-2e6kA:
undetectable		 4otwA-2e6kA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 7 THR A 455
ALA A 350
THR A 351
ALA A 491
 None
 0.96A 4qw0K-2e6kA:
undetectable		 4qw0K-2e6kA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 7 THR A 455
ALA A 350
THR A 351
ALA A 491
 None
 0.96A 4qw0Y-2e6kA:
undetectable		 4qw0Y-2e6kA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 6 LYS A 136
LEU A 137
LEU A 370
ARG A 330
 None
 1.27A 4uswA-2e6kA:
undetectable		 4uswA-2e6kA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		3 / 3 VAL A 553
LEU A 557
VAL A 572
 None
 0.51A 4wq4A-2e6kA:
undetectable		 4wq4A-2e6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 5 GLY A 213
ARG A 240
GLY A 178
GLU A 239
 None
 1.12A 4z2eB-2e6kA:
undetectable
4z2eC-2e6kA:
undetectable		 4z2eB-2e6kA:
23.42
4z2eC-2e6kA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 7 ARG A 642
VAL A 643
LEU A 546
GLU A 645
ALA A 646
 None
 1.23A 5jq7A-2e6kA:
undetectable		 5jq7A-2e6kA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 8 ALA A 358
LEU A 366
LEU A 369
LEU A 499
LEU A 338
 None
 1.22A 5jqbA-2e6kA:
undetectable
5jqbB-2e6kA:
0.0		 5jqbA-2e6kA:
19.60
5jqbB-2e6kA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 6 GLU A 140
ALA A 139
LEU A 137
TYR A 422
 None
 1.10A 5phhA-2e6kA:
undetectable		 5phhA-2e6kA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		3 / 3 MET A 387
GLU A 368
ARG A 398
 None
 1.08A 5tjyA-2e6kA:
2.0		 5tjyA-2e6kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		3 / 3 MET A 387
GLU A 368
ARG A 398
 None
 1.03A 5tjzA-2e6kA:
2.1		 5tjzA-2e6kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		6 / 12 LEU A 536
SER A 551
VAL A 553
ALA A 601
TYR A 534
ALA A 548
 None
 1.37A 5tzoB-2e6kA:
undetectable		 5tzoB-2e6kA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 5 THR A 382
ASN A 381
TRP A 498
LEU A 502
 None
 1.41A 5vkqB-2e6kA:
0.0
5vkqC-2e6kA:
0.0		 5vkqB-2e6kA:
17.56
5vkqC-2e6kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 7 VAL A  48
PRO A  34
PHE A  64
LEU A  74
 None
 1.15A 6aycA-2e6kA:
undetectable		 6aycA-2e6kA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 8 LEU A 156
VAL A  78
LEU A  74
ILE A  15
 None
 0.92A 6cb4A-2e6kA:
undetectable		 6cb4A-2e6kA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		3 / 3 LEU A 335
LEU A 338
ARG A 503
 None
 0.66A 6fgdA-2e6kA:
4.4		 6fgdA-2e6kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		5 / 12 GLU A 493
GLY A 550
TYR A 534
HIS A 554
PRO A 542
 None
 1.16A 6gngA-2e6kA:
2.2		 6gngA-2e6kA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2e6k TRANSKETOLASE
(Thermus
thermophilus) 		4 / 6 MET A 475
LEU A 477
THR A 549
LEU A 511
 None
 1.22A 6mvxA-2e6kA:
undetectable
6mvxB-2e6kA:
undetectable
6mvxC-2e6kA:
undetectable		 6mvxA-2e6kA:
18.22
6mvxB-2e6kA:
18.22
6mvxC-2e6kA:
18.22