SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 7 LEU A 183
THR A 209
LEU A 215
GLY A 214
LEU A 179
 None
 1.39A 1gtiA-2e6mA:
undetectable		 1gtiA-2e6mA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		4 / 4 HIS A 107
VAL A  93
THR A 200
LEU A 205
 None
 1.29A 1oq5A-2e6mA:
undetectable		 1oq5A-2e6mA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		3 / 3 ASP A 137
VAL A 147
PRO A 115
 None
 0.68A 2avvA-2e6mA:
undetectable		 2avvA-2e6mA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 LEU A 155
GLY A  74
CYH A 103
ALA A 211
ALA A 208
 None
 1.01A 2bm9C-2e6mA:
undetectable		 2bm9C-2e6mA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 LEU A 155
GLY A  74
CYH A 103
ALA A 211
ALA A 208
 None
 1.09A 2br4A-2e6mA:
undetectable		 2br4A-2e6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 LEU A 155
GLY A  74
CYH A 103
ALA A 211
ALA A 208
 None
 1.09A 2br4B-2e6mA:
undetectable		 2br4B-2e6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 LEU A 155
GLY A  74
CYH A 103
ALA A 211
ALA A 208
 None
 1.10A 2br4C-2e6mA:
undetectable		 2br4C-2e6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 LEU A 155
GLY A  74
CYH A 103
ALA A 211
ALA A 208
 None
 1.09A 2br4D-2e6mA:
undetectable		 2br4D-2e6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		4 / 5 ILE A 217
LEU A 155
ASP A  76
ALA A 213
 None
 1.06A 2opxA-2e6mA:
undetectable		 2opxA-2e6mA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		4 / 7 PHE A 106
GLY A 117
ASP A  62
ARG A  66
 None
 1.07A 3aruA-2e6mA:
undetectable		 3aruA-2e6mA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		3 / 3 ILE A  94
PHE A 145
HIS A 107
 None
 0.71A 3h0aA-2e6mA:
undetectable		 3h0aA-2e6mA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		3 / 3 HIS A 107
PHE A 114
PHE A 145
 None
 0.68A 3lk0D-2e6mA:
0.0		 3lk0D-2e6mA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		4 / 7 PRO A 115
LEU A 122
ILE A 108
MET A 111
 None
 0.99A 3u5jA-2e6mA:
undetectable		 3u5jA-2e6mA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 9 PRO A 115
VAL A 147
LEU A 122
ILE A 108
MET A 111
 None
 1.10A 4c66A-2e6mA:
undetectable		 4c66A-2e6mA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 ALA A 207
LEU A 199
SER A 109
ILE A 108
LEU A 118
 None
 1.07A 4ky8B-2e6mA:
undetectable		 4ky8B-2e6mA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 ALA A 207
LEU A 199
SER A 109
ILE A 108
LEU A 118
 None
 1.12A 4ky8C-2e6mA:
undetectable		 4ky8C-2e6mA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 ALA A 207
LEU A 199
SER A 109
ILE A 108
LEU A 118
 None
 1.06A 4ky8D-2e6mA:
undetectable		 4ky8D-2e6mA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 12 ALA A 207
LEU A 199
SER A 109
ILE A 108
LEU A 118
 None
 1.06A 4ky8E-2e6mA:
undetectable		 4ky8E-2e6mA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 9 GLU A  78
LEU A 215
VAL A 132
LEU A 171
ILE A 217
 None
None
None
SO4  A 501 (-3.9A)
None
 1.32A 4r38C-2e6mA:
undetectable		 4r38C-2e6mA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		3 / 3 SER A 110
ALA A  92
VAL A  91
 None
 0.40A 4x20C-2e6mA:
undetectable		 4x20C-2e6mA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		4 / 7 GLY A 133
LEU A 118
PHE A 106
PHE A 145
 None
 0.77A 5hieB-2e6mA:
undetectable		 5hieB-2e6mA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 10 ILE A  94
LEU A 118
GLY A  74
ALA A 211
PHE A  75
 None
 1.02A 5mxbA-2e6mA:
undetectable		 5mxbA-2e6mA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		5 / 10 ILE A  94
LEU A 118
PHE A 106
GLY A  74
PHE A  75
 None
 1.05A 5mxbA-2e6mA:
undetectable		 5mxbA-2e6mA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		3 / 3 LYS A 102
LEU A  67
ASP A  62
 None
 0.87A 5zv2A-2e6mA:
undetectable		 5zv2A-2e6mA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG
(Mus
musculus) 		3 / 3 GLY A 131
ASP A 137
ILE A  94
 None
 0.60A 6dgxB-2e6mA:
undetectable		 6dgxB-2e6mA:
18.83