SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2e7a TUMOR NECROSIS
FACTOR
(Homo
sapiens) 		5 / 12 ALA A  38
ALA A  14
LEU A  93
GLY A  40
LEU A 126
 None
 1.17A 1qabF-2e7aA:
undetectable		 1qabF-2e7aA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2e7a TUMOR NECROSIS
FACTOR
(Homo
sapiens) 		4 / 5 ARG A  82
LEU A 132
PRO A  51
VAL A  50
 None
 1.12A 3ufnA-2e7aA:
undetectable
3ufnB-2e7aA:
undetectable		 3ufnA-2e7aA:
18.67
3ufnB-2e7aA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2e7a TUMOR NECROSIS
FACTOR
(Homo
sapiens) 		4 / 8 LEU A  93
ILE A  80
GLY A 153
ILE A 154
 None
 0.74A 3wxoA-2e7aA:
undetectable		 3wxoA-2e7aA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2e7a TUMOR NECROSIS
FACTOR
(Homo
sapiens) 		4 / 8 LEU A 142
ASN A  19
ALA A  18
VAL A  17
 None
 0.91A 4zbqA-2e7aA:
undetectable		 4zbqA-2e7aA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2e7a TUMOR NECROSIS
FACTOR
(Homo
sapiens) 		4 / 8 ILE A  80
PHE A 152
ARG A 131
LEU A 126
 None
 0.93A 5zcoA-2e7aA:
undetectable
5zcoJ-2e7aA:
undetectable		 5zcoA-2e7aA:
14.02
5zcoJ-2e7aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2e7a TUMOR NECROSIS
FACTOR
(Homo
sapiens) 		3 / 3 LEU A 132
LEU A 126
ARG A  82
 None
 0.70A 6fgcA-2e7aA:
undetectable		 6fgcA-2e7aA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2e7a TUMOR NECROSIS
FACTOR
(Homo
sapiens) 		3 / 3 LEU A 132
LEU A 126
ARG A  82
 None
 0.66A 6fgdA-2e7aA:
undetectable		 6fgdA-2e7aA:
16.35