SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e7j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 264
MET A 211
TYR A 349
VAL A 193
PHE A  66
 None
 1.36A 1a27A-2e7jA:
4.0		 1a27A-2e7jA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 119
GLU A 111
ALA A 110
VAL A  96
 None
 0.74A 1a29A-2e7jA:
undetectable		 1a29A-2e7jA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 4 ILE A 336
LEU A 351
VAL A 359
ILE A 333
 None
 0.83A 1fm6D-2e7jA:
undetectable		 1fm6D-2e7jA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  81
VAL A 219
GLY A 218
ALA A 187
ILE A 268
 None
 1.13A 1kxhA-2e7jA:
undetectable		 1kxhA-2e7jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 8 ILE A 366
ILE A 313
GLU A 308
VAL A 309
ILE A 367
 None
 1.28A 1linA-2e7jA:
undetectable		 1linA-2e7jA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 SER A 106
LEU A 152
LEU A 231
VAL A  85
ILE A 203
 None
 1.28A 1uobA-2e7jA:
undetectable		 1uobA-2e7jA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 342
TYR A 311
LYS A 315
 None
 0.68A 1uujB-2e7jA:
undetectable		 1uujB-2e7jA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 6 GLY A 335
HIS A 334
ASN A  11
ILE A 333
 None
 0.76A 1xf1B-2e7jA:
2.0		 1xf1B-2e7jA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 293
HIS A 306
LYS A 291
 None
 0.93A 1y7iA-2e7jA:
2.2		 1y7iA-2e7jA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 10 PHE A  58
GLY A 207
GLY A  77
THR A  75
ALA A  78
 None
None
PLP  A1209 (-3.4A)
None
PLP  A1209 (-3.5A)
 1.05A 2ej3B-2e7jA:
undetectable		 2ej3B-2e7jA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 6 VAL A 230
SER A  88
LEU A 244
PHE A  83
 None
 1.34A 2f8dA-2e7jA:
undetectable		 2f8dA-2e7jA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 11 ILE A 188
GLY A  77
THR A  75
LEU A  63
GLY A 205
 None
PLP  A1209 (-3.4A)
None
None
None
 1.20A 2fn1A-2e7jA:
undetectable		 2fn1A-2e7jA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 157
TYR A 186
HIS A 298
HIS A 300
 None
PLP  A1209 (-4.2A)
None
None
 1.39A 2v0gA-2e7jA:
undetectable		 2v0gA-2e7jA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 166
ALA A 170
VAL A 120
VAL A 193
ILE A 203
 None
 1.00A 3czhA-2e7jA:
undetectable		 3czhA-2e7jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 166
ALA A 170
VAL A 120
VAL A 193
ILE A 203
 None
 1.05A 3dl9A-2e7jA:
undetectable		 3dl9A-2e7jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 139
ILE A 117
TYR A 107
MET A  98
VAL A 178
 None
 1.41A 3ohtA-2e7jA:
0.0
3ohtB-2e7jA:
0.0		 3ohtA-2e7jA:
22.35
3ohtB-2e7jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 6 CYH A 102
ASN A 183
ASP A  99
ILE A 130
 None
PLP  A1209 (-3.0A)
None
None
 1.39A 3w9tB-2e7jA:
undetectable		 3w9tB-2e7jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 10 ALA A  81
ILE A 254
HIS A 208
LEU A 257
ILE A 217
 None
None
PLP  A1209 (-3.5A)
None
None
 1.10A 4dtaA-2e7jA:
undetectable		 4dtaA-2e7jA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 12 ASN A  11
ILE A  10
GLY A 335
ILE A 366
VAL A 359
 None
 0.85A 4nkxB-2e7jA:
undetectable		 4nkxB-2e7jA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		5 / 8 SER A 105
LEU A 152
VAL A  96
ILE A 117
MET A  86
 PLP  A1209 (-3.5A)
None
None
None
None
 1.35A 4oj4A-2e7jA:
undetectable		 4oj4A-2e7jA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		3 / 3 PRO A 192
VAL A 264
HIS A 263
 None
None
SO4  A 602 (-4.0A)
 0.76A 4pevC-2e7jA:
4.1		 4pevC-2e7jA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		3 / 3 ALA A 118
TRP A  95
VAL A  96
 None
 0.41A 4w9nC-2e7jA:
4.0		 4w9nC-2e7jA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 9 SER A 314
ALA A 317
LEU A 324
ILE A 367
 None
 0.96A 4xtaA-2e7jA:
undetectable		 4xtaA-2e7jA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 205
GLY A 189
TYR A 155
ALA A 185
 None
None
None
PLP  A1209 ( 3.7A)
 1.00A 5e26A-2e7jA:
undetectable
5e26B-2e7jA:
undetectable		 5e26A-2e7jA:
21.81
5e26B-2e7jA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2e7j SEP-TRNA:CYS-TRNA
SYNTHASE
(Archaeoglobus
fulgidus) 		4 / 5 HIS A 208
ALA A 185
SER A 206
GLY A 218
 PLP  A1209 (-3.5A)
PLP  A1209 ( 3.7A)
PLP  A1209 (-3.0A)
None
 1.29A 5yodB-2e7jA:
undetectable		 5yodB-2e7jA:
19.02