SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 12 PHE A 107
LEU A 177
VAL A 162
PHE A  74
ALA A 120
 None
 1.22A 1q23A-2e7tA:
undetectable
1q23B-2e7tA:
undetectable		 1q23A-2e7tA:
21.65
1q23B-2e7tA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		4 / 7 GLY A 157
GLY A  88
PHE A 152
PHE A 179
 None
 0.98A 2qwxA-2e7tA:
undetectable
2qwxB-2e7tA:
undetectable		 2qwxA-2e7tA:
21.59
2qwxB-2e7tA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 12 SER A 201
VAL A  57
THR A  70
PHE A  91
ILE A  93
 None
 1.43A 2vdyA-2e7tA:
undetectable		 2vdyA-2e7tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 12 GLY A  88
ALA A  86
PHE A 126
THR A 125
LEU A 154
 None
A2G  A 400 ( 4.3A)
A2G  A 400 ( 3.8A)
None
None
 0.67A 3dh0A-2e7tA:
undetectable		 3dh0A-2e7tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		4 / 4 PRO A 112
TYR A 106
GLY A 101
THR A 100
 None
A2G  A 400 ( 4.7A)
None
None
 0.92A 3ib0A-2e7tA:
undetectable		 3ib0A-2e7tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		4 / 4 PRO A 112
TYR A 110
GLY A 101
THR A 100
 None
 1.11A 3ib0A-2e7tA:
undetectable		 3ib0A-2e7tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		4 / 4 ARG A  77
ASP A 124
GLY A 104
THR A  34
 None
CA  A 303 ( 2.3A)
A2G  A 400 (-3.5A)
None
 1.05A 3k4vB-2e7tA:
undetectable		 3k4vB-2e7tA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 10 PHE A  74
PHE A  72
PHE A 179
ILE A 137
PHE A 123
 None
 1.38A 3t3qB-2e7tA:
undetectable		 3t3qB-2e7tA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 10 PHE A  74
PHE A  72
PHE A 179
ILE A 137
PHE A 123
 None
 1.36A 3t3qD-2e7tA:
undetectable		 3t3qD-2e7tA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 12 SER A 201
VAL A  57
THR A  70
PHE A  91
ILE A  93
 None
 1.44A 4c49B-2e7tA:
undetectable		 4c49B-2e7tA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 12 SER A 201
VAL A  57
THR A  70
PHE A  91
ILE A  93
 None
 1.43A 4c49D-2e7tA:
undetectable		 4c49D-2e7tA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		4 / 7 SER A 214
ASP A 212
TYR A 106
PHE A 126
 GAL  A 401 ( 3.1A)
A2G  A 400 (-4.9A)
A2G  A 400 ( 4.7A)
A2G  A 400 ( 3.8A)
 1.24A 5l1fC-2e7tA:
undetectable		 5l1fC-2e7tA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 7 GLY A 104
GLY A 211
LEU A  33
THR A  46
ALA A 208
 A2G  A 400 (-3.5A)
A2G  A 400 (-3.4A)
None
None
None
 1.38A 5o96C-2e7tA:
undetectable		 5o96C-2e7tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		5 / 10 ILE A 109
GLY A 108
GLY A 103
LEU A  89
VAL A  90
 None
 1.14A 5twjB-2e7tA:
undetectable		 5twjB-2e7tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2e7t BASIC AGGLUTININ
(Psophocarpus
tetragonolobus) 		4 / 6 PHE A 179
PRO A 180
GLY A 183
THR A 184
 None
 0.99A 5x24A-2e7tA:
undetectable		 5x24A-2e7tA:
18.28