SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 VAL A 233
ALA A 201
ARG A 195
LEU A 181
ILE A 203
 None
 1.16A 1d1gB-2e7uA:
undetectable		 1d1gB-2e7uA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 10 ALA A 124
ILE A 283
GLY A 279
PRO A 259
ILE A 236
 None
 0.88A 1sdvA-2e7uA:
undetectable		 1sdvA-2e7uA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 7 TYR A  57
THR A 416
LEU A 387
VAL A 350
ILE A 357
 None
 1.31A 1t87B-2e7uA:
undetectable		 1t87B-2e7uA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 11 ALA A 237
LEU A 225
ALA A 228
LYS A 229
LEU A 257
 None
 0.93A 2bxeB-2e7uA:
2.1		 2bxeB-2e7uA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 PHE A 113
ALA A 275
SER A 116
GLY A 269
GLY A 265
 None
None
PMP  A1001 (-3.7A)
None
None
 1.15A 2igtB-2e7uA:
3.0		 2igtB-2e7uA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 9 TYR A  57
THR A 416
LEU A 387
VAL A 350
ILE A 357
 None
 1.17A 2l8mA-2e7uA:
undetectable		 2l8mA-2e7uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		4 / 6 PHE A 113
LEU A 313
ALA A  96
LEU A  93
 None
 0.89A 2vcvK-2e7uA:
undetectable		 2vcvK-2e7uA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 PRO A 273
GLY A 309
THR A 312
LEU A 304
VAL A  77
 None
 1.06A 2zifA-2e7uA:
undetectable		 2zifA-2e7uA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 PRO A 273
GLY A 309
THR A 312
LEU A 304
VAL A  77
 None
 1.06A 2zifB-2e7uA:
undetectable		 2zifB-2e7uA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 8 TYR A  57
THR A 416
LEU A 387
LEU A 333
VAL A 350
 None
 1.35A 2zujA-2e7uA:
undetectable		 2zujA-2e7uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 10 ALA A 124
ILE A 283
GLY A 279
PRO A 259
ILE A 236
 None
 0.92A 3em3B-2e7uA:
undetectable		 3em3B-2e7uA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 ALA A 124
ILE A 283
GLY A 279
PRO A 259
ILE A 236
 None
 0.98A 3em6B-2e7uA:
undetectable		 3em6B-2e7uA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 10 LEU A  55
HIS A 408
THR A 416
LEU A 404
GLY A 330
 None
 1.30A 3h9uA-2e7uA:
undetectable		 3h9uA-2e7uA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 10 LEU A  55
HIS A 408
THR A 416
LEU A 404
GLY A 330
 None
 1.28A 3h9uD-2e7uA:
undetectable		 3h9uD-2e7uA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 SER A 116
GLY A 117
THR A 118
 PMP  A1001 (-3.7A)
PMP  A1001 (-3.5A)
PMP  A1001 (-3.6A)
 0.14A 3k9wA-2e7uA:
undetectable		 3k9wA-2e7uA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 10 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
 None
 1.31A 3lxiA-2e7uA:
undetectable		 3lxiA-2e7uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 11 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
 None
 1.30A 3lxiB-2e7uA:
undetectable		 3lxiB-2e7uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		4 / 7 ALA A 276
VAL A 108
VAL A 262
LEU A 264
 None
 0.77A 3o14A-2e7uA:
undetectable		 3o14A-2e7uA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 10 ALA A 124
ILE A 283
GLY A 279
PRO A 259
ILE A 236
 None
 0.99A 3oxwB-2e7uA:
undetectable		 3oxwB-2e7uA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 11 ALA A 124
ILE A 283
GLY A 279
PRO A 259
ILE A 236
 None
 0.97A 3oxxD-2e7uA:
undetectable		 3oxxD-2e7uA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		4 / 7 TYR A 325
SER A 405
TYR A  57
HIS A 408
 None
 1.34A 4arcA-2e7uA:
undetectable		 4arcA-2e7uA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 ARG A 129
ARG A 126
ILE A 137
 None
 0.85A 4b7qA-2e7uA:
undetectable		 4b7qA-2e7uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 LEU A 255
GLY A 243
GLY A 265
LEU A 254
GLY A 354
 None
 0.96A 4blvA-2e7uA:
3.8		 4blvA-2e7uA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 9 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
 None
 1.34A 4c9kB-2e7uA:
undetectable		 4c9kB-2e7uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 10 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
 None
 1.33A 4c9nB-2e7uA:
undetectable		 4c9nB-2e7uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 9 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
 None
 1.33A 4c9pA-2e7uA:
undetectable		 4c9pA-2e7uA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 10 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
 None
 1.33A 4c9pB-2e7uA:
undetectable		 4c9pB-2e7uA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 PRO A 289
ARG A 112
ALA A 278
GLY A 279
LEU A 261
 None
 1.50A 4oadA-2e7uA:
undetectable		 4oadA-2e7uA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 VAL A 214
ALA A 212
PHE A 360
 None
 0.79A 4olbA-2e7uA:
2.9		 4olbA-2e7uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 SER A 116
THR A 121
SER A 123
TYR A 277
GLY A 146
 PMP  A1001 (-3.7A)
PMP  A1001 ( 4.8A)
None
None
PMP  A1001 ( 4.1A)
 1.16A 4qb9E-2e7uA:
undetectable		 4qb9E-2e7uA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 SER A 116
THR A 121
SER A 123
TYR A 277
TYR A 144
 PMP  A1001 (-3.7A)
PMP  A1001 ( 4.8A)
None
None
PMP  A1001 (-4.6A)
 1.46A 4qb9E-2e7uA:
undetectable		 4qb9E-2e7uA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 9 ALA A 372
PHE A 360
VAL A 353
GLY A 210
VAL A 216
 None
 1.30A 4r20B-2e7uA:
undetectable		 4r20B-2e7uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 ALA A 311
ARG A  78
ALA A  69
LEU A 272
GLY A 269
 None
 1.14A 4r38A-2e7uA:
undetectable		 4r38A-2e7uA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 ALA A 311
ARG A  78
ALA A  69
LEU A 272
GLY A 269
 None
 1.19A 4r38B-2e7uA:
undetectable		 4r38B-2e7uA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 ALA A 311
ARG A  78
ALA A  69
LEU A 272
GLY A 269
 None
 1.17A 4r38C-2e7uA:
undetectable		 4r38C-2e7uA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 ALA A 311
ARG A  78
ALA A  69
LEU A 272
GLY A 269
 None
 1.16A 4r38D-2e7uA:
undetectable		 4r38D-2e7uA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 GLY A 213
ALA A 212
ILE A 357
ASN A 351
TYR A  57
 None
 1.12A 4rtpA-2e7uA:
3.6		 4rtpA-2e7uA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 VAL A 214
ALA A 212
PHE A 360
 None
 0.71A 4w5nA-2e7uA:
2.6		 4w5nA-2e7uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 VAL A 214
ALA A 212
PHE A 360
 None
 0.80A 4z4iA-2e7uA:
2.6		 4z4iA-2e7uA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		4 / 5 LEU A 225
LEU A 193
PHE A 221
LEU A 181
 None
 0.74A 5gtrA-2e7uA:
undetectable		 5gtrA-2e7uA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 TYR A 105
LEU A 255
THR A 242
GLU A 239
GLY A 256
 None
 1.31A 5jo9A-2e7uA:
undetectable		 5jo9A-2e7uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 VAL A 214
ALA A 212
PHE A 360
 None
 0.77A 5js1A-2e7uA:
2.4		 5js1A-2e7uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 LEU A 337
LEU A 420
ALA A 419
ARG A 332
LEU A  55
 None
 1.20A 5nd7B-2e7uA:
undetectable		 5nd7B-2e7uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 GLY A 146
LEU A 151
HIS A 145
 PMP  A1001 ( 4.1A)
None
None
 0.70A 5u63B-2e7uA:
undetectable		 5u63B-2e7uA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 PHE A 221
ILE A 204
ILE A 203
PHE A 140
VAL A 209
 None
 1.30A 5uanB-2e7uA:
undetectable		 5uanB-2e7uA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		4 / 6 ARG A 195
ARG A 196
LEU A 193
ALA A 224
 None
 0.94A 6b89B-2e7uA:
undetectable		 6b89B-2e7uA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 7 TYR A 105
VAL A 233
ILE A 283
GLY A 243
ALA A 237
 None
 1.49A 6hd6B-2e7uA:
undetectable		 6hd6B-2e7uA:
11.03