SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 5 HIS A  53
HIS A 134
HIS A 244
ASP A  52
 ZN  A1301 (-3.3A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
ZN  A1301 (-3.2A)
 0.97A 1e9yB-2e7yA:
3.1		 1e9yB-2e7yA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 11 ASP A  52
HIS A  53
HIS A 134
ASP A 190
HIS A 244
 ZN  A1301 (-3.2A)
ZN  A1301 (-3.3A)
ZN  A1302 (-3.7A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-3.1A)
 0.78A 2q0jB-2e7yA:
9.4		 2q0jB-2e7yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 11 ASP A  52
HIS A  53
HIS A 134
ASP A 190
LEU A  10
 ZN  A1301 (-3.2A)
ZN  A1301 (-3.3A)
ZN  A1302 (-3.7A)
ZN  A1301 ( 2.3A)
None
 0.73A 2q0jB-2e7yA:
9.4		 2q0jB-2e7yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 5 HIS A 134
HIS A 222
HIS A 244
ASP A  52
 ZN  A1302 (-3.7A)
None
ZN  A1301 (-3.1A)
ZN  A1301 (-3.2A)
 1.20A 3c0zA-2e7yA:
undetectable		 3c0zA-2e7yA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 8 ALA A 235
ALA A 234
PRO A 196
ILE A 199
 None
 0.71A 3dtuC-2e7yA:
undetectable
3dtuD-2e7yA:
undetectable		 3dtuC-2e7yA:
17.00
3dtuD-2e7yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 12 TRP A  14
VAL A  51
VAL A  38
LEU A  34
THR A  33
 PGO  A 601 (-3.8A)
None
None
None
PGO  A 601 (-3.8A)
 1.20A 3elzA-2e7yA:
undetectable		 3elzA-2e7yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 10 HIS A  48
HIS A  50
ASP A  52
HIS A 134
HIS A 244
 ZN  A1302 (-3.5A)
ZN  A1302 (-3.4A)
ZN  A1301 (-3.2A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
 0.86A 4c1dB-2e7yA:
8.0		 4c1dB-2e7yA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 11 HIS A  48
HIS A  50
ASP A  52
HIS A 134
HIS A 244
 ZN  A1302 (-3.5A)
ZN  A1302 (-3.4A)
ZN  A1301 (-3.2A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
 0.85A 4c1fA-2e7yA:
2.8
4c1fB-2e7yA:
8.8		 4c1fA-2e7yA:
20.57
4c1fB-2e7yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 9 HIS A  48
HIS A  50
ASP A  52
HIS A 134
HIS A 244
 ZN  A1302 (-3.5A)
ZN  A1302 (-3.4A)
ZN  A1301 (-3.2A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
 0.87A 4c1hA-2e7yA:
9.3		 4c1hA-2e7yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 8 HIS A  50
ASP A  52
HIS A 134
HIS A 244
 ZN  A1302 (-3.4A)
ZN  A1301 (-3.2A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
 0.81A 4exsB-2e7yA:
3.9		 4exsB-2e7yA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 5 HIS A  53
HIS A 134
HIS A 244
ASP A  52
 ZN  A1301 (-3.3A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
ZN  A1301 (-3.2A)
 0.96A 4h9mA-2e7yA:
2.4		 4h9mA-2e7yA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 8 HIS A  50
ASP A  52
HIS A 134
HIS A 244
 ZN  A1302 (-3.4A)
ZN  A1301 (-3.2A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
 0.79A 5a5zA-2e7yA:
8.3		 5a5zA-2e7yA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2e7y TRNASE Z
(Thermotoga
maritima) 		6 / 11 HIS A  48
HIS A  50
ASP A  52
HIS A  53
HIS A 134
HIS A 244
 ZN  A1302 (-3.5A)
ZN  A1302 (-3.4A)
ZN  A1301 (-3.2A)
ZN  A1301 (-3.3A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
 0.43A 5ayaA-2e7yA:
10.0		 5ayaA-2e7yA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 8 VAL A  86
VAL A 127
ILE A 187
ILE A 145
ILE A  15
 None
 1.18A 5hi2A-2e7yA:
undetectable		 5hi2A-2e7yA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 8 VAL A 106
TYR A  89
THR A  90
ILE A  93
 None
 0.73A 5mzrE-2e7yA:
undetectable		 5mzrE-2e7yA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 8 ASP A 190
HIS A 134
HIS A  48
HIS A 244
 ZN  A1301 ( 2.3A)
ZN  A1302 (-3.7A)
ZN  A1302 (-3.5A)
ZN  A1301 (-3.1A)
 0.93A 5nekD-2e7yA:
undetectable		 5nekD-2e7yA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2e7y TRNASE Z
(Thermotoga
maritima) 		6 / 10 HIS A  48
HIS A  50
HIS A  53
HIS A 134
ASP A 190
HIS A 222
 ZN  A1302 (-3.5A)
ZN  A1302 (-3.4A)
ZN  A1301 (-3.3A)
ZN  A1302 (-3.7A)
ZN  A1301 ( 2.3A)
None
 0.41A 5nzwA-2e7yA:
12.1		 5nzwA-2e7yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 10 HIS A  53
HIS A 244
HIS A  48
ASP A 190
HIS A 134
 ZN  A1301 (-3.3A)
ZN  A1301 (-3.1A)
ZN  A1302 (-3.5A)
ZN  A1301 ( 2.3A)
ZN  A1302 (-3.7A)
 1.18A 5nzwA-2e7yA:
12.1		 5nzwA-2e7yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 10 HIS A 134
HIS A  48
HIS A 222
ASP A 190
HIS A 244
 ZN  A1302 (-3.7A)
ZN  A1302 (-3.5A)
None
ZN  A1301 ( 2.3A)
ZN  A1301 (-3.1A)
 0.96A 5nzwA-2e7yA:
12.1		 5nzwA-2e7yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2e7y TRNASE Z
(Thermotoga
maritima) 		3 / 3 HIS A  53
ASP A 190
HIS A 244
 ZN  A1301 (-3.3A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-3.1A)
 0.76A 5oexA-2e7yA:
3.2		 5oexA-2e7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2e7y TRNASE Z
(Thermotoga
maritima) 		3 / 3 THR A 210
GLU A 208
HIS A 134
 None
None
ZN  A1302 (-3.7A)
 0.75A 5xioA-2e7yA:
undetectable		 5xioA-2e7yA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2e7y TRNASE Z
(Thermotoga
maritima) 		3 / 3 THR A 210
GLU A 208
HIS A 134
 None
None
ZN  A1302 (-3.7A)
 0.77A 5xiqB-2e7yA:
undetectable		 5xiqB-2e7yA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2e7y TRNASE Z
(Thermotoga
maritima) 		3 / 3 THR A 210
GLU A 208
HIS A 134
 None
None
ZN  A1302 (-3.7A)
 0.79A 5xiqD-2e7yA:
undetectable		 5xiqD-2e7yA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2e7y TRNASE Z
(Thermotoga
maritima) 		4 / 8 HIS A  50
ASP A  52
HIS A 134
HIS A 244
 ZN  A1302 (-3.4A)
ZN  A1301 (-3.2A)
ZN  A1302 (-3.7A)
ZN  A1301 (-3.1A)
 0.85A 5zj8A-2e7yA:
2.6		 5zj8A-2e7yA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2e7y TRNASE Z
(Thermotoga
maritima) 		3 / 3 LYS A 259
LEU A 212
ASP A 226
 None
 0.92A 5zv2A-2e7yA:
undetectable		 5zv2A-2e7yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 2e7y TRNASE Z
(Thermotoga
maritima) 		5 / 12 ALA A  26
THR A  33
PHE A  41
VAL A  44
TYR A 143
 None
PGO  A 601 (-3.8A)
None
None
None
 1.33A 6hu9N-2e7yA:
undetectable		 6hu9N-2e7yA:
19.74