SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 8 ILE A 142
ASN A 386
MET A 387
GLY A 143
 None
 0.85A 1dzmA-2e7zA:
undetectable		 1dzmA-2e7zA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 6 PHE A 691
LEU A 433
VAL A 439
GLN A 451
 None
 1.07A 1e7aB-2e7zA:
undetectable		 1e7aB-2e7zA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 ARG A 523
THR A 480
VAL A 468
 None
 0.97A 1hxbA-2e7zA:
undetectable		 1hxbA-2e7zA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 10 LEU A 224
ASP A 221
GLY A 722
GLY A 721
THR A 269
 None
MGD  A 802 (-2.7A)
None
None
None
 1.09A 1k6cA-2e7zA:
undetectable		 1k6cA-2e7zA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 VAL A 439
LEU A 397
MET A 126
ALA A 414
LEU A 433
 None
 1.02A 1r9oA-2e7zA:
undetectable		 1r9oA-2e7zA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 LEU A 122
HIS A 385
ILE A 337
 None
 0.66A 1s9pB-2e7zA:
undetectable		 1s9pB-2e7zA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 ASP A 211
PHE A 169
ASN A 165
 None
 0.49A 1sg9B-2e7zA:
undetectable		 1sg9B-2e7zA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F38_A_15MA325_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 TYR A 101
SER A 131
MET A 126
ASN A 133
PHE A 413
 None
 1.42A 2f38A-2e7zA:
1.3		 2f38A-2e7zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 11 GLY A 328
LEU A 327
PRO A 545
ASN A 386
HIS A 385
 None
 1.24A 2h21B-2e7zA:
undetectable		 2h21B-2e7zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 11 GLY A 328
LEU A 327
PRO A 545
ASN A 386
HIS A 385
 None
 1.28A 2h21C-2e7zA:
undetectable		 2h21C-2e7zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 ILE A 142
ILE A 113
LEU A 719
 None
 0.56A 2prgA-2e7zA:
undetectable		 2prgA-2e7zA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 ASP A  13
THR A  40
PRO A  41
 MGD  A 802 (-3.2A)
MPD  A1004 (-3.4A)
MPD  A1004 ( 4.9A)
 0.61A 2pynB-2e7zA:
undetectable		 2pynB-2e7zA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 ASP A  13
THR A  40
PRO A  41
 MGD  A 802 (-3.2A)
MPD  A1004 (-3.4A)
MPD  A1004 ( 4.9A)
 0.53A 2q64B-2e7zA:
undetectable		 2q64B-2e7zA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 ASP A  13
THR A  40
PRO A  41
 MGD  A 802 (-3.2A)
MPD  A1004 (-3.4A)
MPD  A1004 ( 4.9A)
 0.61A 2qakB-2e7zA:
undetectable		 2qakB-2e7zA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 6 ARG A  73
PHE A 691
GLN A  76
PRO A 687
 None
 1.47A 2qqtA-2e7zA:
undetectable		 2qqtA-2e7zA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 8 ILE A 142
PHE A 384
GLY A 147
ILE A 307
 None
 0.89A 2qwxA-2e7zA:
3.3
2qwxB-2e7zA:
3.3		 2qwxA-2e7zA:
16.48
2qwxB-2e7zA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 THR A  39
PHE A 477
ALA A 159
GLN A 116
PRO A 476
 MPD  A1004 (-3.7A)
MPD  A1004 (-4.5A)
None
None
None
 1.07A 2ve3B-2e7zA:
undetectable		 2ve3B-2e7zA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 8 PHE A 398
TYR A 423
THR A 135
VAL A 409
LEU A 397
 None
 1.37A 2zujA-2e7zA:
undetectable		 2zujA-2e7zA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 MET A 126
GLU A 494
ASN A 114
 None
None
MGD  A 801 (-3.2A)
 0.90A 3a27A-2e7zA:
undetectable		 3a27A-2e7zA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 ALA A 624
ILE A 620
MET A  47
SER A 609
LEU A 621
 None
 1.34A 3gyqA-2e7zA:
2.5
3gyqB-2e7zA:
2.5		 3gyqA-2e7zA:
17.31
3gyqB-2e7zA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 ARG A 314
ILE A 197
THR A 204
 None
None
MGD  A 802 (-4.2A)
 0.72A 3ia4D-2e7zA:
1.1		 3ia4D-2e7zA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 TYR A 574
ASP A 711
ASP A 298
 None
 0.75A 3ou6B-2e7zA:
undetectable		 3ou6B-2e7zA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 ASP A 699
VAL A 702
ILE A 674
ILE A 600
THR A 653
 MGD  A 801 (-3.0A)
None
None
None
None
 0.85A 3spkB-2e7zA:
undetectable		 3spkB-2e7zA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 ASP A  13
THR A  40
PRO A  41
 MGD  A 802 (-3.2A)
MPD  A1004 (-3.4A)
MPD  A1004 ( 4.9A)
 0.51A 3tkgD-2e7zA:
undetectable		 3tkgD-2e7zA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 SER A 157
ASP A 298
ASP A 711
 None
 0.84A 3uj7A-2e7zA:
undetectable		 3uj7A-2e7zA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 10 VAL A 206
SER A 290
ILE A 291
ILE A 197
THR A 204
 None
None
None
None
MGD  A 802 (-4.2A)
 1.29A 3um5A-2e7zA:
undetectable		 3um5A-2e7zA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 6 THR A 269
GLY A 219
ASP A 221
ILE A 170
 None
MGD  A 802 (-3.5A)
MGD  A 802 (-2.7A)
MGD  A 802 (-4.7A)
 0.86A 3w9tF-2e7zA:
undetectable		 3w9tF-2e7zA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 LEU A 199
GLY A 219
GLY A 722
LEU A 224
GLY A 270
 MGD  A 802 (-4.6A)
MGD  A 802 (-3.5A)
None
None
None
 1.17A 4blvA-2e7zA:
undetectable		 4blvA-2e7zA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 6 PHE A 413
PHE A 497
ALA A  91
LEU A 129
 None
 1.01A 4ejgD-2e7zA:
undetectable		 4ejgD-2e7zA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 8 ILE A 340
ARG A 523
PRO A 466
VAL A 468
 None
 1.24A 4f4dB-2e7zA:
undetectable		 4f4dB-2e7zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 5 HIS A 343
ALA A 389
HIS A 385
GLN A 341
 None
 1.49A 4gboA-2e7zA:
undetectable		 4gboA-2e7zA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 8 GLY A 102
LYS A 410
SER A 105
TYR A 101
GLU A 404
 None
NA  A1001 ( 4.0A)
None
None
NA  A1001 ( 2.8A)
 1.36A 4hyfB-2e7zA:
undetectable		 4hyfB-2e7zA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 8 GLY A 102
LYS A 410
SER A 105
TYR A 101
GLU A 404
 None
NA  A1001 ( 4.0A)
None
None
NA  A1001 ( 2.8A)
 1.43A 4hyfC-2e7zA:
undetectable		 4hyfC-2e7zA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 9 THR A 449
LEU A 433
ALA A 419
LEU A 397
PHE A 412
 None
 1.32A 4ltwA-2e7zA:
1.2		 4ltwA-2e7zA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 6 ASN A 418
ALA A 419
TYR A 423
ASP A 699
 MGD  A 801 (-4.9A)
None
None
MGD  A 801 (-3.0A)
 0.99A 4mdbA-2e7zA:
undetectable		 4mdbA-2e7zA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 SER A 136
MET A 391
ASP A 705
 None
 0.86A 4mm4B-2e7zA:
undetectable		 4mm4B-2e7zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 SER A 157
ASP A 298
ASP A 711
 None
 0.79A 4mwzA-2e7zA:
undetectable		 4mwzA-2e7zA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 ASP A 699
VAL A 702
ILE A 674
ILE A 600
THR A 653
 MGD  A 801 (-3.0A)
None
None
None
None
 0.87A 4njuA-2e7zA:
undetectable		 4njuA-2e7zA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 ASP A 699
VAL A 702
ILE A 674
ILE A 600
THR A 653
 MGD  A 801 (-3.0A)
None
None
None
None
 0.86A 4njuC-2e7zA:
undetectable		 4njuC-2e7zA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 THR A 204
ALA A 666
LEU A 605
ASP A 664
LEU A 631
 MGD  A 802 (-4.2A)
None
MGD  A 802 (-4.4A)
None
None
 1.33A 4pbhA-2e7zA:
undetectable		 4pbhA-2e7zA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 GLY A 171
ILE A 170
PRO A 201
LEU A 216
TYR A 218
 MGD  A 802 (-3.5A)
MGD  A 802 (-4.7A)
MGD  A 802 (-4.3A)
MGD  A 802 (-4.8A)
MGD  A 802 (-3.9A)
 0.94A 4pd4C-2e7zA:
undetectable		 4pd4C-2e7zA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 5 SER A 155
GLY A 154
ARG A 150
PHE A 384
 None
 1.17A 4r82A-2e7zA:
undetectable
4r82B-2e7zA:
undetectable		 4r82A-2e7zA:
14.13
4r82B-2e7zA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 8 PRO A 470
PHE A 158
GLY A 328
ALA A 329
MET A 387
 None
MPD  A1005 (-4.5A)
None
None
None
 1.03A 4zjzB-2e7zA:
undetectable		 4zjzB-2e7zA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 7 TYR A 383
SER A 375
GLU A 372
PRO A 558
 None
 1.07A 5aclA-2e7zA:
undetectable		 5aclA-2e7zA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 9 ASP A 298
HIS A 149
ASN A 144
ILE A 307
SER A 155
 None
 1.30A 5ha9B-2e7zA:
undetectable		 5ha9B-2e7zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 LEU A 186
GLN A 182
LEU A 168
GLY A 171
LYS A 172
 None
None
None
MGD  A 802 (-3.5A)
None
 1.17A 5i8fA-2e7zA:
undetectable		 5i8fA-2e7zA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 VAL A 108
SER A 109
TRP A 134
 None
 0.88A 5jwaA-2e7zA:
undetectable		 5jwaA-2e7zA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 8 TRP A  83
GLU A 490
PRO A 487
GLY A 459
 None
None
None
MGD  A 801 ( 3.9A)
 0.99A 5kgpA-2e7zA:
undetectable		 5kgpA-2e7zA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 8 TRP A  83
GLU A 490
PRO A 487
GLY A 459
 None
None
None
MGD  A 801 ( 3.9A)
 1.00A 5kgpB-2e7zA:
undetectable		 5kgpB-2e7zA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 SER A 117
TYR A 495
TYR A 119
 None
 0.90A 5lakA-2e7zA:
undetectable
5lakI-2e7zA:
undetectable		 5lakA-2e7zA:
16.60
5lakI-2e7zA:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 ILE A 307
HIS A 153
GLY A 147
GLY A 143
TYR A 156
 None
 1.11A 5nnaA-2e7zA:
undetectable		 5nnaA-2e7zA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 ILE A 307
HIS A 153
GLY A 147
GLY A 143
TYR A 156
 None
 1.10A 5nnaC-2e7zA:
undetectable		 5nnaC-2e7zA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 ILE A 307
HIS A 153
GLY A 147
GLY A 143
TYR A 156
 None
 1.14A 5nnaD-2e7zA:
undetectable		 5nnaD-2e7zA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 7 THR A 449
PHE A 398
MET A 401
THR A 135
 None
 1.35A 5u6mB-2e7zA:
undetectable		 5u6mB-2e7zA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 5 HIS A 343
ALA A 389
HIS A 385
GLN A 341
 None
 1.49A 5uizA-2e7zA:
undetectable		 5uizA-2e7zA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 8 ARG A 314
ALA A 309
PHE A 569
SER A 566
 None
 0.82A 5v0vA-2e7zA:
undetectable		 5v0vA-2e7zA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		3 / 3 GLY A 328
THR A 480
PRO A 470
 None
 0.66A 5v5zA-2e7zA:
undetectable		 5v5zA-2e7zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 12 GLY A 143
SER A 136
MET A 138
PHE A 384
TYR A 365
 None
 1.08A 5yf0A-2e7zA:
undetectable		 5yf0A-2e7zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 5 GLY A 219
ASP A 221
ARG A 720
GLN A 714
 MGD  A 802 (-3.5A)
MGD  A 802 (-2.7A)
MGD  A 802 (-2.5A)
None
 1.31A 5zrfB-2e7zA:
2.2		 5zrfB-2e7zA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		5 / 9 LEU A 599
THR A 671
GLY A 721
ILE A 723
ILE A 674
 None
 1.17A 6ebpA-2e7zA:
undetectable		 6ebpA-2e7zA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2e7z ACETYLENE HYDRATASE
AHY
(Pelobacter
acetylenicus) 		4 / 5 GLN A 444
GLU A 464
ASP A 493
TYR A 442
 MGD  A 801 (-3.5A)
None
None
MGD  A 801 (-3.7A)
 0.90A 6iftA-2e7zA:
0.0		 6iftA-2e7zA:
18.23