SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e80'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 8 PRO A 278
GLU A 281
GLU A 249
ARG A 387
 None
 1.24A 1dtlA-2e80A:
undetectable		 1dtlA-2e80A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		5 / 12 LYS A 484
GLU A 161
GLY A 159
ASN A 164
ASP A 160
 None
 1.17A 2br4B-2e80A:
undetectable		 2br4B-2e80A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 4 LYS A 448
LEU A  77
ALA A 451
LEU A  83
 None
 1.39A 2roxA-2e80A:
undetectable		 2roxA-2e80A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		3 / 3 SER A 181
GLU A 147
ASP A 187
 None
 0.86A 3bwmA-2e80A:
undetectable		 3bwmA-2e80A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 8 HIS A 299
GLY A 316
ASN A 317
PHE A 404
 HEM  A1511 (-3.3A)
HEM  A1510 (-4.1A)
HEM  A1511 (-3.2A)
HEM  A1511 ( 3.8A)
 1.34A 3ccfA-2e80A:
undetectable		 3ccfA-2e80A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		3 / 3 ASP A 137
ARG A 486
ALA A  48
 None
 0.75A 3mbgC-2e80A:
0.5		 3mbgC-2e80A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 7 GLN A 107
GLU A 474
PHE A 469
PRO A 118
 None
 1.34A 3ql6A-2e80A:
undetectable		 3ql6A-2e80A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		6 / 12 GLN A 390
PHE A 356
TYR A  96
GLY A 360
ALA A  82
ALA A 451
 None
None
HEM  A1508 (-4.6A)
None
None
None
 1.34A 3sudB-2e80A:
undetectable		 3sudB-2e80A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 5 SER A 181
LYS A 180
LEU A 186
ASP A 187
 None
 1.24A 4ifxA-2e80A:
undetectable		 4ifxA-2e80A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 5 SER A 181
LYS A 180
LEU A 186
ASP A 187
 None
 1.25A 4ig1A-2e80A:
undetectable		 4ig1A-2e80A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		3 / 3 TYR A 169
GLN A 213
TRP A  64
 None
HEM  A1510 ( 4.7A)
HEM  A1509 (-3.9A)
 1.15A 4kn2C-2e80A:
undetectable		 4kn2C-2e80A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		5 / 11 TYR A  96
GLU A 217
LEU A  83
LEU A  77
SER A  93
 HEM  A1508 (-4.6A)
CA  A 513 (-2.2A)
None
None
None
 1.41A 4m7tA-2e80A:
undetectable		 4m7tA-2e80A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 5 GLY A 116
ALA A 117
GLY A 124
PRO A 125
 None
 0.86A 4u9uA-2e80A:
undetectable		 4u9uA-2e80A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 5 GLY A 116
ALA A 117
GLY A 124
PRO A 125
 None
 0.88A 4u9uB-2e80A:
undetectable		 4u9uB-2e80A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 5 SER A 181
LYS A 180
LEU A 186
ASP A 187
 None
 1.25A 4xdtA-2e80A:
0.0		 4xdtA-2e80A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 5 GLU A 371
THR A 270
HIS A 385
LEU A 428
 None
 1.19A 5axaA-2e80A:
undetectable		 5axaA-2e80A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 5 GLU A 371
THR A 270
HIS A 385
LEU A 428
 None
 1.23A 5axaC-2e80A:
undetectable		 5axaC-2e80A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		3 / 3 THR A 375
ASP A 376
ALA A 377
 None
 0.08A 5g5gB-2e80A:
undetectable		 5g5gB-2e80A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 6 PHE A  92
TRP A  87
SER A  93
GLY A  89
 None
 1.02A 5o4yF-2e80A:
undetectable		 5o4yF-2e80A:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 6 GLU A 205
LYS A 196
LEU A 190
LEU A 209
 None
 1.18A 5yvnA-2e80A:
undetectable		 5yvnA-2e80A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2e80 CYTOCHROME C-552
(Wolinella
succinogenes) 		4 / 9 HIS A 277
ASP A 279
LEU A 319
SER A 325
 NO2  A 704 ( 3.6A)
HEM  A1511 ( 4.0A)
HEM  A1511 (-4.6A)
None
 0.84A 6c2mD-2e80A:
undetectable		 6c2mD-2e80A:
11.64