SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		3 / 3 ILE A 298
LEU A 301
VAL A 305
 None
 0.27A 1mz9B-2e87A:
undetectable		 1mz9B-2e87A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
HIS A 259
ASP A 294
 GDP  A 400 (-2.8A)
None
None
 0.84A 1nw5A-2e87A:
undetectable		 1nw5A-2e87A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		4 / 6 VAL A 326
LYS A 327
ILE A 313
ILE A 290
 None
 0.69A 2piwA-2e87A:
undetectable		 2piwA-2e87A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 ILE A 313
ALA A 186
GLY A 320
THR A 321
GLY A 322
 None
 1.09A 2y7hB-2e87A:
undetectable		 2y7hB-2e87A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		4 / 5 VAL A 162
VAL A 163
GLN A 208
ARG A 215
 None
 1.33A 3bjwH-2e87A:
undetectable		 3bjwH-2e87A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		4 / 6 ILE A 250
PHE A 304
PHE A 254
TYR A 252
 None
 1.12A 3elzB-2e87A:
undetectable		 3elzB-2e87A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		4 / 6 VAL A 171
VAL A 163
ILE A 204
ARG A 244
 None
 1.05A 3pyyA-2e87A:
undetectable		 3pyyA-2e87A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 11 ILE A 172
ILE A 250
ILE A 218
THR A 333
VAL A 326
 None
 1.10A 3tmzA-2e87A:
undetectable		 3tmzA-2e87A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 11 ILE A 330
ILE A 323
ALA A 186
ILE A 172
VAL A 170
 None
 0.96A 4h1nA-2e87A:
undetectable		 4h1nA-2e87A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 PRO A 176
CYH A 260
ASN A 288
ALA A 317
LEU A 318
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.7A)
GDP  A 400 (-4.0A)
 1.37A 4oadA-2e87A:
undetectable		 4oadA-2e87A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		6 / 12 LEU A 334
ILE A 167
GLN A 208
ILE A 330
ILE A 218
PHE A 209
 None
 1.40A 4rp8C-2e87A:
2.2		 4rp8C-2e87A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		4 / 7 PHE A   5
THR A  73
VAL A  82
PHE A  77
 None
SO4  A 401 ( 4.5A)
None
None
 0.95A 4wnvD-2e87A:
undetectable		 4wnvD-2e87A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 LEU A 284
LEU A 249
ILE A 251
ILE A 172
ILE A 218
 None
 0.80A 4y0rA-2e87A:
undetectable		 4y0rA-2e87A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		4 / 6 PHE A 304
LEU A 310
ASN A 311
PRO A 312
 None
 1.45A 4yv5B-2e87A:
undetectable		 4yv5B-2e87A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 LEU A  85
TYR A  78
LEU A 246
LEU A 243
ALA A 195
 None
 1.22A 5ieoA-2e87A:
undetectable		 5ieoA-2e87A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 LEU A  85
TYR A  78
LEU A 246
LEU A 243
ALA A 195
 None
 1.21A 5iepA-2e87A:
undetectable		 5iepA-2e87A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 10 ILE A 250
THR A 221
ILE A 172
ILE A 219
ILE A 218
 None
 1.10A 5murE-2e87A:
4.4		 5murE-2e87A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 ILE A 323
GLY A 322
SER A 316
ALA A 317
ALA A 186
 None
None
GDP  A 400 (-3.1A)
GDP  A 400 (-3.7A)
None
 1.05A 5n0oB-2e87A:
2.2		 5n0oB-2e87A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 10 ALA A  14
LEU A  17
LEU A  61
VAL A 139
ILE A 105
 None
 1.02A 5v02B-2e87A:
4.2
5v02R-2e87A:
undetectable		 5v02B-2e87A:
14.29
5v02R-2e87A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2e87 HYPOTHETICAL PROTEIN
PH1320
(Pyrococcus
horikoshii) 		5 / 12 GLY A 179
ILE A 172
VAL A 286
ASP A 220
ALA A 186
 GDP  A 400 (-3.1A)
None
None
None
None
 1.04A 6bq4B-2e87A:
undetectable		 6bq4B-2e87A:
13.25