SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A
(Aquifex
aeolicus) 		3 / 3 PHE A  54
LEU A 119
LEU A 116
 None
 0.62A 1mx1E-2e8bA:
undetectable		 1mx1E-2e8bA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A
(Aquifex
aeolicus) 		5 / 12 PHE A 101
VAL A 118
ASN A 184
VAL A  42
LEU A 103
 None
 1.17A 2ft9A-2e8bA:
undetectable		 2ft9A-2e8bA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A
(Aquifex
aeolicus) 		4 / 7 TYR A 169
VAL A 126
TYR A 141
ILE A 160
 None
 1.24A 3bu1A-2e8bA:
undetectable		 3bu1A-2e8bA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A
(Aquifex
aeolicus) 		5 / 12 THR A 136
TRP A 161
ILE A 149
ILE A  85
SER A  84
 None
 1.14A 3kpbA-2e8bA:
undetectable		 3kpbA-2e8bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A
(Aquifex
aeolicus) 		5 / 10 THR A 136
TRP A 161
ILE A 149
ILE A  85
SER A  84
 None
 1.13A 3kpbD-2e8bA:
undetectable		 3kpbD-2e8bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A
(Aquifex
aeolicus) 		5 / 12 LEU A 163
LEU A 164
LEU A 134
ILE A 149
VAL A 102
 None
 1.24A 4f4dB-2e8bA:
2.3		 4f4dB-2e8bA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A
(Aquifex
aeolicus) 		5 / 10 LEU A 163
LEU A 164
LEU A 134
ILE A 149
VAL A 102
 None
 1.30A 4mk4A-2e8bA:
2.3		 4mk4A-2e8bA:
20.74